DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17684 and Dpp6

DIOPT Version :9

Sequence 1:	NP_001015352.3	Gene:	CG17684 / 3355066	FlyBaseID:	FBgn0263780	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_038963130.1	Gene:	Dpp6 / 29272	RGDID:	68402	Length:	867	Species:	Rattus norvegicus

Alignment Length:	886	Identity:	269/886 - (30%)
Similarity:	435/886 - (49%)	Gaps:	128/886 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GGGGGSWRLPPDETLQVQ-----DPKQKDHDFDFDE-------GHNWRSIILSLLVISFVVSGIV 63
            ||.||..|      .|.|     |.:.|:.|...:|       ..||:.|.::||||..:.|.||
  Rat    55 GGAGGRPR------FQYQARSDCDEEDKNQDTPLEELVGSNPPQRNWKGIAIALLVILVICSLIV 113

  Fly    64 TAIYLLGYVDELLYWSGRRMILDEYLQGDLIPRRLPSSWVTTQKYVFQSDDGSLAVLDTTTNLVK 128
            |::.||...::......:::.:::....|.......:.|::.::::::...||:.:.:..||...
  Rat   114 TSVILLTPAEDTSLSQKKKVTVEDLFSEDFKIHDPEAKWISDKEFIYRERKGSVILRNVETNNST 178

  Fly   129 VLVTNHTLRQLNVRRYLCSSDLKYVLFTHNVKKNFQKSFTAFYTIYDVTNDHHTPVKLKDTLKVQ 193
            ||:....:..|...||..|.|.:|.||::||:..:|.|.|.:|.:..:  .|..|..| |..:|.
  Rat   179 VLIEGKKIESLRAIRYEISPDKEYALFSYNVEPVYQHSHTGYYVLSKI--PHGDPQSL-DPPEVS 240

  Fly   194 RTRLQYASWLGNTTAIIFVVKNDIFIRQSPLVEEDIRITSSGHENHIYNGVPDWLYQEEIFETPE 258
            ..:||||.|......:||:.:|:|:. .:.:.::.||:.|:|.|..||||:.||||:|||.::..
  Rat   241 NAKLQYAGWGPKGQQLIFIFENNIYY-CAHVGKQAIRVVSTGKEGVIYNGLSDWLYEEEILKSHI 304

  Fly   259 AIWTSSDGTHFMYALFNDTNVGMMTYPWLSSGALFSGSGIFSGSIFPETKMVRFPTPGTTNPEVE 323
            |.|.|.|||...||..||:.|.:|..|            .::||::|..|...:|..|:.||.:.
  Rat   305 AHWWSPDGTRLAYATINDSRVPLMELP------------TYTGSVYPTVKPYHYPKAGSENPSIS 357

  Fly   324 LWAVDITN-LSDIQKFNIKPPATIYGQDYYLTSAGWISDSNCQVSVVYMGRSQNYSVISLCSKEE 387
            |..:.:.. ..|::   :.||.....::||:|...|.:.:  :|:|.::.|:||.|:::||....
  Rat   358 LHVIGLNGPTHDLE---MMPPDDPRMREYYITMVKWATST--KVAVTWLNRAQNVSILTLCDATT 417

  Fly   388 DWKCLEVHSERAPEDEWLDIFPH-----PVFSSDGSSFLFLANIQESENYQFTHIKHVMISQ--- 444
            . .|.:.|.:.:  :.||    |     ||||.||..|.|:..|.:....:|.||. |..||
  Rat   418 G-VCTKKHEDES--EAWL----HRQNEEPVFSKDGRKFFFVRAIPQGGRGKFYHIT-VSSSQPNS 474

  Fly   445 --RRISVISHGRYEVTKILCWDTINHKVYFMATQDKKPGQRHLYSVQDPIHDDIRKVEPQCITCD 507
              ..|..|:.|.::||:||.:|...:|:||::|:| .|.:|||||....  ||..:   ||::||
  Rat   475 SNDNIQSITSGDWDVTEILTYDEKRNKLYFLSTED-LPRRRHLYSANTV--DDFNR---QCLSCD 533

  Fly   508 LGDDLWSSRYYYTNCTHFEAFITPSLGVATNYGIEFYILECQGPGLPVSGVHMQTTHSLVKILYD 572
            |.:          |||:..|        :.::.::|::|:|:|||:|...||..|         |
  Rat   534 LVE----------NCTYVSA--------SFSHNMDFFLLKCEGPGVPTVTVHNTT---------D 571

  Fly   573 TRPFY----TERLQKLALPTQ------RSFEV---PLPHGGRAQVQLLLPPSWREELRDAAFPVI 624
            .|..:    .|::||.....|      |..||   .||      :|:|.|.::.:   .|.:|::
  Rat   572 KRRMFDLEANEQVQKAINDRQMPKIEYRKIEVEDYSLP------MQILKPATFTD---TAHYPLL 627

  Fly   625 VEVNGRPGSESVSEKFKIDWGTYMSSRNDVVYIRLDVRGSKGQSKKTLY---RHLGGVEVLDQIS 686
            :.|:|.|||:||||:|::.|.|.:.|.:..|.::.|.|||..|..|.|:   |.||.:|..||:.
  Rat   628 LVVDGTPGSQSVSERFEVTWETVLVSSHGAVVVKCDGRGSGFQGTKLLHEVRRRLGFLEEKDQME 692

  Fly   687 VIGYLLDTIGFLDETRVGMWGWGYGGYVTSMAL----GTQQDVFKCGIAVSPTADW-LY-STFTE 745
            .:..:|.. .::|:|||.::|..||||:::..|    ..|...|.||.|:||..|: || |.|:|
  Rat   693 AVRTMLKE-QYIDKTRVAVFGKDYGGYLSTYILPAKGENQGQTFTCGSALSPITDFKLYASAFSE 756

  Fly   746 RILGLPAENFKGYVEADATQRARLIKSNSYFLIHGLADTTAPFVHGVQLAKSLTSANILFRYQTY 810
            |.|||...:.:.|.......|...::...:.:||..||....|.|..:|...|......:..|.|
  Rat   757 RYLGLHGLDNRAYEMTKLAHRVSALEDQQFLIIHATADEKIHFQHTAELITQLIKGKANYSLQIY 821

  Fly   811 ADEGHDLSGVL--EHVYSSMEQYFAECLSLD---PDDTKPE 846
            .||.|....|.  :|:|.|:..:|.||..:.   |..|..|
  Rat   822 PDESHYFHSVALKQHLYRSIIGFFVECFRIQDKLPTATAKE 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17684	NP_001015352.3	DPPIV_N	147..554	CDD:279298	134/417 (32%)
CG17684	NP_001015352.3	Abhydrolase	643..836	CDD:304388	66/203 (33%)
Dpp6	XP_038963130.1	DPPIV_N	197..563	CDD:395744	134/418 (32%)
Dpp6	XP_038963130.1	Abhydrolase	643..852	CDD:419691	68/209 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	189	1.000	Domainoid score	I3205
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		otm45634
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	O	PTHR11731
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.780