DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17684 and SPACUNK4.08

DIOPT Version :9

Sequence 1:	NP_001015352.3	Gene:	CG17684 / 3355066	FlyBaseID:	FBgn0263780	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_593970.1	Gene:	SPACUNK4.08 / 2542415	PomBaseID:	SPACUNK4.08	Length:	793	Species:	Schizosaccharomyces pombe

Alignment Length:	905	Identity:	219/905 - (24%)
Similarity:	365/905 - (40%)	Gaps:	222/905 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 HDFDF-DEGHNWRS---------------IILSLLVISFVVSGIVTAIYLLGYVDELLYWSGRR- 82
            :||.| |:|...||               :|.|||::...:|.:..:             ..:|
pombe     2 NDFSFEDKGLISRSGFGSRHVRRVVKALALIFSLLILYLTISNVSDS-------------PPKRD 53

  Fly    83 -MILDEYLQGDLIPRRLPSSWVTTQ--KYVFQSDDGSLAVLDTTTNLVKVLVTNHTL----RQLN 140
             :.||:.:.....|.....:|:.:|  |..|....|.|..:....||.|.|.:...|    .||:
pombe    54 SLSLDDIVLQKYKPSYKQVNWIDSQGLKDTFLVKYGDLINIQDPYNLNKTLFSVSDLVYNGIQLD 118

  Fly   141 VRRYLCSSDLKYVLFTHNVKKNFQKSFTAFYTIY-----DVT-----NDHHTPVKLKDTLKVQRT 195
            ...|..|.|.||||.:.|..:.::.|..|.|.:|     ||.     |:|.|
pombe   119 YDSYSISFDAKYVLVSVNKSQRWRHSSFAQYYLYNTETKDVNMLGQDNEHWT------------- 170

  Fly   196 RLQYASWLGNTTAIIFVVKNDIFIRQSPLVEEDI-RITSSGHENHIYNGVPDWLYQEEIFETPEA 259
             :..|.|......:.||..||:::|::   :.:: |:|..|..: ::||:.||:|:||:..:|..
pombe   171 -ISLAEWSPTGHQLSFVYNNDLYVRKN---DGNVQRLTYDGTVD-VFNGLTDWIYEEEVLSSPST 230

  Fly   260 IWTSSDGTHFMYALFNDTNVGMMTYPWLSSGALFSGSGIFSGSIFP--------ETKMVRFPTPG 316
            ||.|.|.....:...|::.:....||            :::..:.|        :...:::|.||
pombe   231 IWWSPDSDKIAFLKLNESEIPTYHYP------------LYTAELDPSLPEFDYNKDMAIKYPKPG 283

  Fly   317 TTNPEVELWAVDITN--LSDIQKFNIKPPATIYGQDYYLTSAGWISDSNCQVSVVYMGRSQNYSV 379
            ..||.|.|:..|:.:  .|:...::.:|.|....|:..     |::.|    ||:....::|.:.
pombe   284 NPNPSVSLFVADLNSNASSNFSLWHNEPLAEPVVQNVL-----WVNTS----SVLVQFTNRNSTC 339

  Fly   380 ISLCSKEEDWKCLEVHSERAPEDEWLDI------FPHPVFSSDGSSFLFLANIQESENY------ 432
            |:....:.:.|.:........|:.|.::      ||             |.|....||:
pombe   340 ITARLLDTELKSIHTVKTECLEEGWYEVQQSAKMFP-------------LNNSLVWENWSDGYFD 391

  Fly   433 -----QFTHIKHVMISQRRISVISHGRYEVTKILCWDTINH------KVYFMATQDKKPGQRHLY 486
                 .:.|:..:..:......::.|.::||     |...|      .|||:||. |...:||||
pombe   392 ILALDDYNHLAFIPFNGSSPIYLTSGAWDVT-----DGPIHIDGDFGNVYFLATL-KDSTERHLY 450

  Fly   487 SVQDPIHDDIRKVEPQCITCDLGDDLWSSRYYYTNCTHFEAFITPSLGVATNYGIEFYILECQGP 551
            .|      .:..:|...|| |.|:|   ..||.|:.:.|.               :||:|...||
pombe   451 YV------SLDTLEIYGIT-DNGED---EGYYSTSFSPFG---------------DFYVLNYHGP 490

  Fly   552 GLPVSGVHMQTTHSLVKILYDTRPFYTERLQKLALPT-------------------QRSFEVPLP 597
            .:|...:. .|......:..:|.....::|..:.||:                   .|:|:|
pombe   491 DVPWQELR-STKDKDYCLSLETNSRLKQQLSSITLPSVEYGKLTFNDTTFNFMERRPRNFDV--- 551

  Fly   598 HGGRAQVQLLLPPSWREELRDAAFPVIVEVNGRPGSESVSEKFKIDWGTYMSSRND--VVYIRLD 660
                                :..:||:....|.|||:.|::.|::|:..|::|..|  .:.:.||
pombe   552 --------------------NKKYPVLFFAYGGPGSQQVAKLFRVDFQAYLASHPDFEFIVVTLD 596

  Fly   661 VRGS--KGQS-KKTLYRHLGGVEVLDQISVIGYLLDTIGFLDETRVGMWGWGYGGYVTSMALGTQ 722
            .||:  .|.: :.::.||||..|..|| ...|.....:.|:||..||:|||.||||:|...|.|
pombe   597 GRGTGFNGNAFRYSVSRHLGEWESYDQ-GQAGKFWADLPFVDENHVGIWGWSYGGYLTLKTLET- 659

  Fly   723 QDVFKCGIAVSPTADW-LY-STFTERILGLPAENFKGYVEADATQRARLIKSNSYFLIHGLADTT 785
            ||||..|:||:|..|| || |.:|||.:.||..|.:||..:......:..:...:|:.||..|..
pombe   660 QDVFSYGMAVAPVTDWRLYDSVYTERYMDLPQYNKEGYKNSQIHDYEKFKQLKRFFVAHGTGDDN 724

  Fly   786 APFVHGVQLAKSLTSANILFRYQ--TYADEGHDLS--GVLEHVYSSMEQYFAECLS-LDP 840
            ..|.|.:.|...|..|| .:.|.  .:.|..|.:|  .....:|..:.::..:.|. :||
pombe   725 VHFQHSMHLMDGLNLAN-CYNYDMAVFPDSAHSISYHNASLSIYHRLSEWIGDALGRIDP 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17684	NP_001015352.3	DPPIV_N	147..554	CDD:279298	101/450 (22%)
CG17684	NP_001015352.3	Abhydrolase	643..836	CDD:304388	68/203 (33%)
SPACUNK4.08	NP_593970.1	DPPIV_N	125..494	CDD:279298	101/451 (22%)
SPACUNK4.08	NP_593970.1	Peptidase_S9	574..779	CDD:278741	69/207 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	136	1.000	Domainoid score	I1258
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	O	PTHR11731
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
TreeFam	0	0.000	Not matched by this tool.
	8	7.810