DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17684 and Dpp9

DIOPT Version :9

Sequence 1:	NP_001015352.3	Gene:	CG17684 / 3355066	FlyBaseID:	FBgn0263780	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_001347213.1	Gene:	Dpp9 / 224897	MGIID:	2443967	Length:	921	Species:	Mus musculus

Alignment Length:	736	Identity:	168/736 - (22%)
Similarity:	284/736 - (38%)	Gaps:	185/736 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 FVVKNDIFIRQSPLVEEDIRIT-----SSG-HENHIYNGVPDWLYQEEI------FETPEAIWTS 263
            |:..:|:::......||. |:|     |:| .:|....||..::.|||.      :..|.|.|..
Mouse   261 FINNSDLWVANIETGEER-RLTFCHQGSAGVLDNPKSAGVATFVIQEEFDRFTGCWWCPTASWEG 324

  Fly   264 SDGTHFMYALFNDTNVGMMTYPWLSSGALFSGSGIFSGSIFPETKMVRFPTPGTTNPEVELWAVD 328
            |:|...:..|:.:.:...:....:.|.||..          .:|...|:|..|:.||::.|...:
Mouse   325 SEGLKTLRILYEEVDESEVEVIHVPSPALEE----------RKTDSYRYPRTGSKNPKIALKLAE 379

  Fly   329 ITN------LSDIQKFNIKPPATIYGQDYYLTSAGWISDSNCQVSVVYMGRSQNYSVISLCSKEE 387
            :..      :|..:|..::|.::::.:..|:..|||..|.. ....:::.|.|....:.|.....
Mouse   380 LQTDHQGKIVSSCEKELVQPFSSLFPKVEYIARAGWTRDGK-YAWAMFLDRPQQRLQLVLLPPAL 443

  Fly   388 DWKCLEVHSER------APE------------DEWL---DIFPHPVFSSDG-SSFLFL-ANIQES 429
            ....:|..::|      .|:            :.|:   ||| ||...::| ..|.|| ||..::
Mouse   444 FIPAVESEAQRQAAARAVPKNVQPFVIYEEVTNVWINVHDIF-HPFPQAEGQQDFCFLRANECKT 507

  Fly   430 ENYQFTHIKHVMIS-----------------------QRRISVISHGRYEV-----TKILCWDTI 466
               .|.|:..|.:.                       :..:::.| |.:||     :||  |  :
Mouse   508 ---GFCHLYRVTVELKTKDYDWTEPLSPTEDEFKCPIKEEVALTS-GEWEVLSRHGSKI--W--V 564

  Fly   467 NHK---VYFMATQDKKPGQRHLYSVQDPIHDDIRKVEPQCITCDLGDDLWSSRYYYTNCT---HF 525
            |.:   |||..|:| .|.:.|||.|......:|.::      ..||        :..:|:   .|
Mouse   565 NEQTKLVYFQGTKD-TPLEHHLYVVSYESAGEIVRL------TTLG--------FSHSCSMSQSF 614

  Fly   526 EAFITPSLGVATNYGIEFYILECQGPGLPVSGVHMQTTHSLVKILYDTRPFYTERLQKLALPTQR 590
            :.|::....|:|...:..|.|  .||  ....:|.|..            |:...::....|..
Mouse   615 DMFVSHYSSVSTPPCVHVYKL--SGP--DDDPLHKQPR------------FWASMMEAANCPPD- 662

  Fly   591 SFEVP---LPHGGRAQVQL--------LLPPSWREELRDAAFPVIVEVNGRPGSESVSEKFKIDW 644
              .||   .....||.|||        .|.|..:.       |.::.|.|.|..:.|:..||
Mouse   663 --YVPPEIFHFHTRADVQLYGMIYKPHTLQPGRKH-------PTVLFVYGGPQVQLVNNSFK--- 715

  Fly   645 GTYMSSRNDVVYIRLDVRGSKGQS----------------KKTLYRHLGGVEVLDQISVIGYLLD 693
                    .:.|:||:...|.|.:                :..|...:|.||:.||:..:.|:.:
Mouse   716 --------GIKYLRLNTLASLGYAVVVIDGRGSCQRGLHFEGALKNQMGQVEIEDQVEGLQYVAE 772

  Fly   694 TIGFLDETRVGMWGWGYGGYVTSMALGTQQDVFKCGIAVSPTADWL-YST-FTERILGLPAENFK 756
            ..||:|.:||.:.||.|||:::.|.|..:..|||..||.:|...|: |.| :|||.:.:|..|.:
Mouse   773 KYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQQ 837

  Fly   757 GYVEADATQRARLI--KSNSYFLIHGLADTTAPFVHGVQLAKSLTSANILFRYQTYADEGHDL-- 817
            ||...........:  :.|...::||..|....|.|...|...|..|...::.|.|.:|.|.:
Mouse   838 GYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRC 902

  Fly   818 --SGVLEHVYSSMEQYFAECL 836
              ||  ||...::..:..|.|
Mouse   903 RESG--EHYEVTLLHFLQEHL 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17684	NP_001015352.3	DPPIV_N	147..554	CDD:279298	89/417 (21%)
CG17684	NP_001015352.3	Abhydrolase	643..836	CDD:304388	58/216 (27%)
Dpp9	NP_001347213.1	DPPIV_N	204..628	CDD:332444	85/402 (21%)
Dpp9	NP_001347213.1	Peptidase_S9	720..921	CDD:278741	57/202 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810