DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17684 and FAP

DIOPT Version :9

Sequence 1:	NP_001015352.3	Gene:	CG17684 / 3355066	FlyBaseID:	FBgn0263780	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_004451.2	Gene:	FAP / 2191	HGNCID:	3590	Length:	760	Species:	Homo sapiens

Alignment Length:	793	Identity:	238/793 - (30%)
Similarity:	401/793 - (50%)	Gaps:	109/793 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 RRMILDEYLQGDLIPRRLPSSWVTTQKYVFQSDDGSLAVLDTTTNLVKVLVTNHTLRQLNVRRYL 145
            |.:.|.:.|.|....:....:|::.|:|:.||.|.::.:.:..|.....:::|.|::.:|...|.
Human    40 RALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYG 104

  Fly   146 CSSDLKYVLFTHNVKKNFQKSFTAFYTIYDVTNDHHTPVKLKDTLKVQRTRL----QYASWLGNT 206
            .|.|.::|....:..|.::.|:||.|.|||::|...          |:...|    ||..|....
Human   105 LSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEF----------VRGNELPRPIQYLCWSPVG 159

  Fly   207 TAIIFVVKNDIFIRQSPLVEEDIRITSSGHENHIYNGVPDWLYQEEIFETPEAIWTSSDGTHFMY 271
            :.:.:|.:|:|:::|.| .:...:||.:|.||.|:||:|||:|:||:..|..|:|.|.:|....|
Human   160 SKLAYVYQNNIYLKQRP-GDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAY 223

  Fly   272 ALFNDTNVGMMTYPWLSSGALFSGSGIFSGSIFPETKMVRFPTPGTTNPEVELWAVDITNLSDIQ 336
            |.||||::.::.|.:            :....:|.|..:.:|..|..||.|.::.:|.|..:.:.
Human   224 AEFNDTDIPVIAYSY------------YGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVG 276

  Fly   337 KFNIKPPATIYGQDYYLTSAGWISDSNCQVSVVYMGRSQNYSVISLCSKEEDWK---C--LEVHS 396
            ...:..||.|...|||.:...|::|.  :|.:.::.|.||.||:|:|...|||:   |  .:.|.
Human   277 PQEVPVPAMIASSDYYFSWLTWVTDE--RVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHI 339

  Fly   397 ERAPEDEWLDIF--PHPVFSSDGSSFLFLANIQESENYQFTHIKHVMISQRRISVISHGRYEVTK 459
            |.: ...|...|  ..||||.|..|:..:  ..:.:.|:  ||.::..:......|:.|:
Human   340 EES-RTGWAGGFFVSTPVFSYDAISYYKI--FSDKDGYK--HIHYIKDTVENAIQITSGK----- 394

  Fly   460 ILCWDTINHKVYFMATQD----------KKPGQRHLYSVQDPIHDDIRKVEPQCITCDLGDDLWS 514
               |:.||   .|..|||          :.||:|::|.:....:...:|    |:||.|..:
Human   395 ---WEAIN---IFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKK----CVTCHLRKE--- 446

  Fly   515 SRYYYTNCTHFEAFITPSLGVATNYGIEFYILECQGPGLPVSGVHMQTTHSLVKILYDTRPFYTE 579
                  .|.::.|..       ::|. ::|.|.|.|||:|:|.:|...|...:|||.:.:.. ..
Human   447 ------RCQYYTASF-------SDYA-KYYALVCYGPGIPISTLHDGRTDQEIKILEENKEL-EN 496

  Fly   580 RLQKLALPTQ--RSFEVPLPHGGRAQV----QLLLPPSWREELRDAAFPVIVEVNGRPGSESVSE 638
            .|:.:.||.:  :..||.       ::    :::|||.:.   |...:|::::|.|.|.|:||..
Human   497 ALKNIQLPKEEIKKLEVD-------EITLWYKMILPPQFD---RSKKYPLLIQVYGGPCSQSVRS 551

  Fly   639 KFKIDWGTYMSSRNDVVYIRLDVRGSKGQSKKTL---YRHLGGVEVLDQISVIGYLLDTIGFLDE 700
            .|.::|.:|::|:..:|...:|.||:..|..|.|   ||.||..||.|||:.:...:: :||:||
Human   552 VFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIE-MGFIDE 615

  Fly   701 TRVGMWGWGYGGYVTSMALGTQQDVFKCGIAVSPTADWLY--STFTERILGLPA--ENFKGYVEA 761
            .|:.:|||.|||||:|:||.:...:|||||||:|.:.|.|  |.:|||.:|||.  :|.:.|..:
Human   616 KRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNS 680

  Fly   762 DATQRARLIKSNSYFLIHGLADTTAPFVHGVQLAKSLTSANILFRYQTYADEGHDLSGV-LEHVY 825
            ....||...::..|.||||.||....|.:..|:||:|.:|.:.|:...|:|:.|.|||: ..|:|
Human   681 TVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLY 745

  Fly   826 SSMEQYFAECLSL 838
            :.|..:..:|.||
Human   746 THMTHFLKQCFSL 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17684	NP_001015352.3	DPPIV_N	147..554	CDD:279298	117/427 (27%)
CG17684	NP_001015352.3	Abhydrolase	643..836	CDD:304388	79/200 (40%)
FAP	NP_004451.2	DPPIV_N	106..472	CDD:366374	117/427 (27%)
FAP	NP_004451.2	Peptidase_S9	553..756	CDD:366030	80/203 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		otm41514
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.720