DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17684 and Fap

DIOPT Version :9

Sequence 1:	NP_001015352.3	Gene:	CG17684 / 3355066	FlyBaseID:	FBgn0263780	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_620205.1	Gene:	Fap / 192203	RGDID:	621253	Length:	761	Species:	Rattus norvegicus

Alignment Length:	799	Identity:	234/799 - (29%)
Similarity:	396/799 - (49%)	Gaps:	116/799 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 SGRRMILDEYLQGDLIPRRLPSSWVTTQKYVFQSDDGSLAVLDTTTNLVKVLVTNHTLRQLNVRR 143
            :||.:.|.:.|.|....:....:|::.|:|:.||:|.::...:..|....::::|.|::.:|...
  Rat    38 TGRSLTLKDILNGTFSYKTYFPNWISEQEYLHQSEDDNIVFYNIETRESYIILSNSTMKSVNATD 102

  Fly   144 YLCSSDLKYVLFTHNVKKNFQKSFTAFYTIYDVTN-----DHHTPVKLKDTLKVQRTRLQYASWL 203
            |..|.|.:::....:..|.::.|:||.|.|||:.|     .:..|           ..:||..|.
  Rat   103 YGLSPDRQFIYLESDYSKLWRYSYTATYYIYDLQNGEFVRGYELP-----------RPIQYLCWS 156

  Fly   204 GNTTAIIFVVKNDIFIRQSPLVEEDIRITSSGHENHIYNGVPDWLYQEEIFETPEAIWTSSDGTH 268
            ...:.:.:|.:|:|:::|.| .:...:||.:|.||.|:||:|||:|:||:..|..|:|.|.||.:
  Rat   157 PVGSKLAYVYQNNIYLKQRP-GDPPFQITYTGRENRIFNGIPDWVYEEEMLATKYALWWSPDGKY 220

  Fly   269 FMYALFNDTNVGMMTYPWLSSGALFSGSGIFSGSIFPETKMVRFPTPGTTNPEVELWAVDITNLS 333
            ..|..|||:::.::.|.:...|.            :|.|..:.:|..|..||.|.::.||.....
  Rat   221 LAYVEFNDSDIPIIAYSYYGDGQ------------YPRTINIPYPKAGAKNPIVRVFIVDTIYPH 273

  Fly   334 DIQKFNIKPPATIYGQDYYLTSAGWISDSNCQVSVVYMGRSQNYSVISLCSKEEDWKCLEVHSER 398
            .:....:..|..|...|||.|...|:  :|.:|.:.::.|.||.||:|:|...|||     |:..
  Rat   274 HVGPIEVPVPEMIASSDYYFTWLTWV--TNERVCLQWLKRVQNVSVLSICDFREDW-----HAWD 331

  Fly   399 APEDE---------WLDIF--PHPVFSSDGSSFLFLANIQESENYQFTHIKHVMISQRRISVISH 452
            .|:::         |...|  ..|.||.|.:|:..:  ..:.:.|:  ||.::..:......|:.
  Rat   332 CPKNQEHIEESRTGWAGGFFVSTPAFSQDAASYYKI--FSDKDGYK--HIHYIKDTVENAIQITS 392

  Fly   453 GRYEVTKILCWDTINHKVYFMATQDK----------KPGQRHLYSVQDPIHDDIRKVEP--QCIT 505
            |::|...|           |..|||.          .||:|::|.:      .|....|  :|:|
  Rat   393 GKWEAIYI-----------FRVTQDSLFYSSNEFEGYPGRRNIYRI------SIGNSPPSKKCVT 440

  Fly   506 CDLGDDLWSSRYYYTNCTHFEAFITPSLGVATNYGIEFYILECQGPGLPVSGVHMQTTHSLVKIL 570
            |.|..:         .|.::.|        :.:|..::|.|.|.|||||:|.:|...|...:::|
  Rat   441 CHLRKE---------RCQYYTA--------SFSYKAKYYALICYGPGLPISTLHDGRTDQEIQVL 488

  Fly   571 YDTRPFYTERLQKLALPTQRSFEV-PLPHGGRA-QVQLLLPPSWREELRDAAFPVIVEVNGRPGS 633
            .:.:.. ...|:.:.||   :.|: .|..||.. ..:::|||.:.   |...:|::::|.|.|.|
  Rat   489 EENKEL-ENALRNIQLP---AVEIKKLEDGGMTFWYKMILPPQFD---RSKKYPLLIQVYGGPCS 546

  Fly   634 ESVSEKFKIDWGTYMSSRNDVVYIRLDVRGSKGQSKKTL---YRHLGGVEVLDQISVIGYLLDTI 695
            :||...|.::|.||::|:..:|...:|.||:..|..|.|   ||.||..||.||::.:...:: :
  Rat   547 QSVKSVFSVNWITYLASKEGIVVALVDGRGTAFQGDKFLHAVYRKLGVYEVEDQLTAVRKFIE-M 610

  Fly   696 GFLDETRVGMWGWGYGGYVTSMALGTQQDVFKCGIAVSPTADWLY--STFTERILGLPA--ENFK 756
            ||:||.|:.:|||.|||||:|:||.:...:|||||||:|.:.|.|  |.:|||.:|||.  :|.:
  Rat   611 GFIDEGRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASIYTERFMGLPTKDDNLE 675

  Fly   757 GYVEADATQRARLIKSNSYFLIHGLADTTAPFVHGVQLAKSLTSANILFRYQTYADEGHDLSG-- 819
            .|..:....||...::..|.||||.||....|.:..|:||:|.:|.:.|:...|:|:.|.:|.
  Rat   676 HYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGISSGR 740

  Fly   820 VLEHVYSSMEQYFAECLSL 838
            ...|:|:.|..:..:|.||
  Rat   741 SQNHLYTHMTHFLKQCFSL 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17684	NP_001015352.3	DPPIV_N	147..554	CDD:279298	113/434 (26%)
CG17684	NP_001015352.3	Abhydrolase	643..836	CDD:304388	77/201 (38%)
Fap	NP_620205.1	DPPIV_N	106..473	CDD:279298	114/435 (26%)
Fap	NP_620205.1	Peptidase_S9	553..760	CDD:278741	81/208 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		otm45634
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720