DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17684 and dpf-2

DIOPT Version :9

Sequence 1:	NP_001015352.3	Gene:	CG17684 / 3355066	FlyBaseID:	FBgn0263780	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_510461.1	Gene:	dpf-2 / 181579	WormBaseID:	WBGene00001055	Length:	829	Species:	Caenorhabditis elegans

Alignment Length:	878	Identity:	211/878 - (24%)
Similarity:	372/878 - (42%)	Gaps:	161/878 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VQDPKQKDHDFDFDE-GHNWRSIILSLLVISFVVSGIVTAIYLLGYVDELLYWSGRRMILDEYLQ 90
            :|:|...:.|..|:: ..|..|:..:.|...|  |.::|......:  |.|: ||::.::|.|
Worm    48 MQNPINLNSDNGFNQTSGNTSSLEATTLKPKF--SSLMTTTRRFTF--EQLF-SGKQFLVDYY-- 105

  Fly    91 GDLIPRRLPSSWVTTQKYVFQSDDGSLAVLDTTTNLVKVLVTNHTLRQ--LNVRRYL--CSSDLK 151
             |.|       |:....:|..:||      .|....:|.:....::.:  .|...|:  .||::|
Worm   106 -DYI-------WLPDGSFVQMNDD------FTIRKQMKKIPLGSSVAEPFFNNGEYVKALSSNMK 156

  Fly   152 YVLFTHNVKKNFQKSFTAFYTIYDVTND-------HHTPVKLKDTLKVQRTRLQYASWLGNTTA- 208
            |...:..|.:.::.|....|.|..:.|.       |..|        .:.:.:|...|..|.::
Worm   157 YAYGSKKVNELWRHSAEYLYHIVKINNKTVSTEQWHVGP--------EENSLIQAFYWNPNASSN 213

  Fly   209 -IIFVVKNDIFIRQSPLVEED-IRITSSGHENHIYNGVPDWLYQEEIFETPEAIWTSSDGTHFMY 271
             .::|...:::.::.|...:. |::|..|...:.: |:.:|||:|||.|...|:|.|..|.:..|
Worm   214 DFVYVHNYNLYYQKDPEKPDGAIQLTVGGSTFNRF-GLANWLYEEEILEASSAVWWSPSGRYVSY 277

  Fly   272 ALFNDTNVGMMTYPWLSSGALFSGSGIFSGSIFPETKMVRFPTPGTTNPEV---ELWAVDITNLS 333
            ..|:|..|..:..|..:           ....:.|...:.:|..|..|..:   .:|  |..|..
Worm   278 LRFDDREVNRIFLPKYT-----------DDDSYVEYFELPYPKAGVQNNTLVTQYIW--DSENHK 329

  Fly   334 DIQKFNIKPPATIYGQ--DYYLTSAGWI------SD-SNCQVSVVYMGRSQNYSVISLCSKEEDW 389
            .::   ..||..:...  |||:.:..||      || ...::..|:..|.||:...|||::::
Worm   330 IVE---TAPPNELSAANGDYYVLTNKWITMPRNGSDLGEERLVTVWANRDQNHVYFSLCNEQD-- 389

  Fly   390 KCLEVHSERAPEDE---WLD------IFPHPVFSSDGSSFLFLANIQESENYQFTHIKHVMISQR 445
             |:...|.:...|.   |:.      :||      ..:.||.:...:..:...:.|:.||.:.
Worm   390 -CVMALSFQFSIDNRQLWVSPKDVRGVFP------TETGFLTVLPHKHDDGNIYNHVAHVELD-- 445

  Fly   446 RISVISHGRYEVTKILCWDTINHKVYFMATQDKK------------PGQRHLYSVQDPIHDDIRK 498
                 ..|..::||   |...|..|..:.....|            .|:...|.|::.::.: :|
Worm   446 -----GTGTGKITK---WIGENFDVILVLGYSSKIDALTFSAYGDGVGEFSTYIVREAMYSN-KK 501

  Fly   499 VEPQCITCDLGDDLWSSRYYYTNCTHFEAFITPSLGVATNYGIEFYILECQGPGLPVSGVHMQTT 563
            ...|.:|                 ..||...|.....|...| :..:::|:.|       ...|.
Worm   502 TTLQKVT-----------------DQFEDCKTLGSQSADPTG-QRIVVQCEKP-------FDNTR 541

  Fly   564 HSLVKILYDTRPFYTERLQKLALPTQRSFEVP--------LPHGGRAQVQLLLPPSWREELRDAA 620
            ..||.::..|:....|...|..:|    |:||        ||.|......:|.|.:.   |..|.
Worm   542 LYLVDVVDTTKKIMLEGGTKAVIP----FDVPNMKFGKLKLPSGIDGHYMMLTPANL---LDGAK 599

  Fly   621 FPVIVEVNGRPGSESVSEKFKIDWGTYMSSRNDVVYIRLDVRGSKGQS---KKTLYRHLGGVEVL 682
            .|:::::.|.|.|:.|.:|........:.|:.|:.|.|:||||:.|:.   |:.:||.||..||:
Worm   600 IPLLLDIYGGPDSKQVFQKTPTAHAIQIVSQYDIAYARIDVRGTGGRGWDVKEAVYRKLGDAEVV 664

  Fly   683 DQISVIGYLLDTIGFLDETRVGMWGWGYGGYVTS-MALGTQQDVFKCGIAVSPTADWLY--STFT 744
            |.:.:|...::|.||:||.|:.:.||.|||::|| :|:..|.::.||.|:::|..|:.|  |.:|
Worm   665 DTLDMIRAFINTFGFIDEDRIAVMGWSYGGFLTSKIAIKDQGELVKCAISIAPVTDFKYYDSAYT 729

  Fly   745 ERILGLPAENFKGYVEADATQRARLIKSNSYFLIHGLADTTAPFVHGVQLAKSLTSANILFRYQT 809
            ||.||.||||.:||:..:....||.:.:..|.|.||..|....:.:..:.:::|....|.|....
Worm   730 ERYLGQPAENLQGYINTNVIPHARNVTNVKYLLAHGERDDNVHYQNSARWSEALQQNGIHFTQLV 794

  Fly   810 YADEGHDLSGVLEHVYSSMEQYFA-ECLSLDPD 841
            ||:|.|.||..|.|:|..::::.. :|...:.|
Worm   795 YANEAHSLSHKLFHLYGEVQRFLMNDCFKSNLD 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17684	NP_001015352.3	DPPIV_N	147..554	CDD:279298	90/449 (20%)
CG17684	NP_001015352.3	Abhydrolase	643..836	CDD:304388	70/199 (35%)
dpf-2	NP_510461.1	DPPIV_N	152..536	CDD:279298	89/446 (20%)
		FrsA	567..817	CDD:223999	85/252 (34%)
		Peptidase_S9	623..801	CDD:278741	64/177 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46052
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		mtm8410
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	O	PTHR11731
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.830