Protein Alignment CG17684 and DPP6

DIOPT Version :10

• Sequence 1: NP_001015352.3
• Gene: CG17684 / 3355066
• FlyBaseID: FBgn0263780
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_570629.2
• Gene: DPP6 / 1804
• HGNCID: 3010
• Length: 865
• Species: Homo sapiens
• Alignment Length: 871
• Identity: 262/871 - (30%)
• Similarity: 433/871 - (49%)
• Gaps: 116/871 - (13%)

  Fly     8 DRSGGGGGSWRLP-----------PDETLQVQDPKQKDHDFDFDEGHNWRSIILSLLVISFVVSG 61
            :|.|||||:...|           .::.|...:|.|:          ||:.|.::||||..:.|.
Human    55 ERGGGGGGAGGRPRFQYQARSDGDEEDELVGSNPPQR----------NWKGIAIALLVILVICSL 109

  Fly    62 IVTAIYLLGYVDELLYWSGRRMILDEYLQGDLIPRRLPSSWVTTQKYVFQSDDGSLAVLDTTTNL 126
            |||::.||...::......:::.:::....|.......:.|::..:::::...|::.:.:..||.
Human   110 IVTSVILLTPAEDNSLSQKKKVTVEDLFSEDFKIHDPEAKWISDTEFIYREQKGTVRLWNVETNT 174

  Fly   127 VKVLVTNHTLRQLNVRRYLCSSDLKYVLFTHNVKKNFQKSFTAFYTIYDVTNDHHTPVKLKDTLK 191
            ..||:....:..|...||..|.|.:|.||::||:..:|.|:|.:|.:..:  .|..|..| |..:
Human   175 STVLIEGKKIESLRAIRYEISPDREYALFSYNVEPIYQHSYTGYYVLSKI--PHGDPQSL-DPPE 236

  Fly   192 VQRTRLQYASWLGNTTAIIFVVKNDIFIRQSPLVEEDIRITSSGHENHIYNGVPDWLYQEEIFET 256
            |...:||||.|......:||:.:|:|:. .:.:.::.||:.|:|.|..||||:.||||:|||.:|
Human   237 VSNAKLQYAGWGPKGQQLIFIFENNIYY-CAHVGKQAIRVVSTGKEGVIYNGLSDWLYEEEILKT 300

  Fly   257 PEAIWTSSDGTHFMYALFNDTNVGMMTYPWLSSGALFSGSGIFSGSIFPETKMVRFPTPGTTNPE 321
            ..|.|.|.|||...||..||:.|.:|..|            .::|||:|..|...:|..|:.||.
Human   301 HIAHWWSPDGTRLAYAAINDSRVPIMELP------------TYTGSIYPTVKPYHYPKAGSENPS 353

  Fly   322 VELWAVDITN-LSDIQKFNIKPPATIYGQDYYLTSAGWISDSNCQVSVVYMGRSQNYSVISLCSK 385
            :.|..:.:.. ..|::   :.||.....::||:|...|.:.:  :|:|.::.|:||.|:::||..
Human   354 ISLHVIGLNGPTHDLE---MMPPDDPRMREYYITMVKWATST--KVAVTWLNRAQNVSILTLCDA 413

  Fly   386 EEDWKCLEVHSERAPEDEWLDIFPH-----PVFSSDGSSFLFLANIQESENYQFTHIKHVMISQ- 444
            ... .|.:.|.:.:  :.||    |     ||||.||..|.|:..|.:....:|.||. |..||
Human   414 TTG-VCTKKHEDES--EAWL----HRQNEEPVFSKDGRKFFFIRAIPQGGRGKFYHIT-VSSSQP 470

  Fly   445 ----RRISVISHGRYEVTKILCWDTINHKVYFMATQDKKPGQRHLYSVQDPIHDDIRKVEPQCIT 505
                ..|..|:.|.::|||||.:|...:|:||::|:| .|.:|.|||.     :.:.....||::
Human   471 NSSNDNIQSITSGDWDVTKILAYDEKGNKIYFLSTED-LPRRRQLYSA-----NTVGNFNRQCLS 529

  Fly   506 CDLGDDLWSSRYYYTNCTHFEAFITPSLGVATNYGIEFYILECQGPGLPVSGVHMQTTHSLVKIL 570
            |||.:          |||:|.|        :.::.::|::|:|:|||:|:..||..|..   |.:
Human   530 CDLVE----------NCTYFSA--------SFSHSMDFFLLKCEGPGVPMVTVHNTTDK---KKM 573

  Fly   571 YD--TRPFYTERLQKLALP--TQRSFEVP---LPHGGRAQVQLLLPPSWREELRDAAFPVIVEVN 628
            :|  |.....:.:....:|  ..|..|:.   ||      :|:|.|.::.:...   :|:::.|:
Human   574 FDLETNEHVKKAINDRQMPKVEYRDIEIDDYNLP------MQILKPATFTDTTH---YPLLLVVD 629

  Fly   629 GRPGSESVSEKFKIDWGTYMSSRNDVVYIRLDVRGSKGQSKKTLY---RHLGGVEVLDQISVIGY 690
            |.|||:||:|||::.|.|.|.|.:..|.::.|.|||..|..|.|:   |.||.:|..||:..:..
Human   630 GTPGSQSVAEKFEVSWETVMVSSHGAVVVKCDGRGSGFQGTKLLHEVRRRLGLLEEKDQMEAVRT 694

  Fly   691 LLDTIGFLDETRVGMWGWGYGGYVTSMAL----GTQQDVFKCGIAVSPTADW-LY-STFTERILG 749
            :|.. .::|.|||.::|..||||:::..|    ..|...|.||.|:||..|: || |.|:||.||
Human   695 MLKE-QYIDRTRVAVFGKDYGGYLSTYILPAKGENQGQTFTCGSALSPITDFKLYASAFSERYLG 758

  Fly   750 LPAENFKGYVEADATQRARLIKSNSYFLIHGLADTTAPFVHGVQLAKSLTSANILFRYQTYADEG 814
            |...:.:.|.......|...::...:.:||..||....|.|..:|...|......:..|.|.||.
Human   759 LHGLDNRAYEMTKVAHRVSALEEQQFLIIHPTADEKIHFQHTAELITQLIRGKANYSLQIYPDES 823

  Fly   815 H--DLSGVLEHVYSSMEQYFAECLSL 838
            |  ..|.:.:|:|.|:..:|.||..:
Human   824 HYFTSSSLKQHLYRSIINFFVECFRI 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17684	NP_001015352.3	DPPIV_N	147..554	CDD:395744	135/417 (32%)
		Peptidase_S9	643..836	CDD:459761	67/203 (33%)
DPP6	NP_570629.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..88		8/32 (25%)
		DPPIV_N	195..561	CDD:395744	135/418 (32%)
		Peptidase_S9	641..847	CDD:459761	68/206 (33%)