Protein Alignment CG17684 and DPP4

DIOPT Version :10

• Sequence 1: NP_001015352.3
• Gene: CG17684 / 3355066
• FlyBaseID: FBgn0263780
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_001926.2
• Gene: DPP4 / 1803
• HGNCID: 3009
• Length: 766
• Species: Homo sapiens
• Alignment Length: 826
• Identity: 246/826 - (29%)
• Similarity: 411/826 - (49%)
• Gaps: 97/826 - (11%)

  Fly    45 WRSIILSLLVISFVVSGIVTAIYLLGY-VDELLYWSGRRMILDEYLQGDLIPRRLPSSWVTTQKY 108
            |: ::|.||..:.:|:.|...:.||.. .|:....|.:...|.:||:.....:.....|::..:|
Human     5 WK-VLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEY 68

  Fly   109 VFQSDDGSLAVLDTTTNLVKVLVTNHTLRQL--NVRRYLCSSDLKYVLFTHNVKKNFQKSFTAFY 171
            :::.:: ::.|.:.......|.:.|.|..:.  ::..|..|.|.:::|..:|..|.::.|:||.|
Human    69 LYKQEN-NILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASY 132

  Fly   172 TIYDVTNDHHTPVKLKDTLKVQR--TRLQYASWLGNTTAIIFVVKNDIFIRQSPLVEEDIRITSS 234
            .|||:..        :..:..:|  ...|:.:|......:.:|..|||:::..|.: ...|||.:
Human   133 DIYDLNK--------RQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNL-PSYRITWT 188

  Fly   235 GHENHIYNGVPDWLYQEEIFETPEAIWTSSDGTHFMYALFNDTNVGMMTYPWLSSGALFSGSGIF 299
            |.|:.||||:.||:|:||:|....|:|.|.:||...||.||||.|.::.|.:.|..:|
Human   189 GKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESL------- 246

  Fly   300 SGSIFPETKMVRFPTPGTTNPEVELWAVD------ITNLSDIQKFNIKPPATIYGQDYYLTSAGW 358
               .:|:|..|.:|..|..||.|:.:.|:      :||.:.||   |..||::...|:||....|
Human   247 ---QYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQ---ITAPASMLIGDHYLCDVTW 305

  Fly   359 ISDSNCQVSVVYMGRSQNYSVISLCSKEED---WKCL--EVHSERAPEDEWLDIF----PHPVFS 414
            .:..  ::|:.::.|.|||||:.:|..:|.   |.||  ..|.|.:... |:..|    ||  |:
Human   306 ATQE--RISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTG-WVGRFRPSEPH--FT 365

  Fly   415 SDGSSFLFLANIQESENYQFTHIKHVMISQRRISVISHGRYEVTKI--LCWDTINHKVYFMATQD 477
            .||:||..:  |...|.|:  ||.:..|.::..:.|:.|.:||..|  |..|.:    |:::.:.
Human   366 LDGNSFYKI--ISNEEGYR--HICYFQIDKKDCTFITKGTWEVIGIEALTSDYL----YYISNEY 422

  Fly   478 K-KPGQRHLYSVQDPIHDDIRKVEPQCITCDLGDDLWSSRYYYTNCTHFEAFITPSLGVATNYGI 541
            | .||.|:||.:|   ..|..||  .|::|:|..:         .|.::        .|:.:...
Human   423 KGMPGGRNLYKIQ---LSDYTKV--TCLSCELNPE---------RCQYY--------SVSFSKEA 465

  Fly   542 EFYILECQGPGLPVSGVHMQTTHSLVKILYDTRPFYTERLQKLALPTQRSFEVPLPHGGRAQVQL 606
            ::|.|.|.|||||:..:|.......:::|.|.... .:.||.:.:|::: .:..:.:..:...|:
Human   466 KYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSAL-DKMLQNVQMPSKK-LDFIILNETKFWYQM 528

  Fly   607 LLPPSWREELRDAAFPVIVEVNGRPGSESVSEKFKIDWGTYMSSRNDVVYIRLDVRGSKGQSKKT 671
            :|||.:.:..:   :|::::|...|.|:.....|:::|.||::|..:::....|.|||..|..|.
Human   529 ILPPHFDKSKK---YPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKI 590

  Fly   672 LY---RHLGGVEVLDQISVIGYLLDTIGFLDETRVGMWGWGYGGYVTSMALGTQQDVFKCGIAVS 733
            ::   |.||..||.|||.. ......:||:|..|:.:|||.||||||||.||:...||||||||:
Human   591 MHAINRRLGTFEVEDQIEA-ARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVA 654

  Fly   734 PTADWLY--STFTERILGLPA--ENFKGYVEADATQRARLIKSNSYFLIHGLADTTAPFVHGVQL 794
            |.:.|.|  |.:|||.:|||.  :|...|..:....||...|...|.||||.||....|....|:
Human   655 PVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQI 719

  Fly   795 AKSLTSANILFRYQTYADEGHDL--SGVLEHVYSSMEQYFAECLSL 838
            :|:|....:.|:...|.||.|.:  |...:|:|:.|..:..:|.||
Human   720 SKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSL 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17684	NP_001015352.3	DPPIV_N	147..554	CDD:395744	128/426 (30%)
		Peptidase_S9	643..836	CDD:459761	78/201 (39%)
DPP4	NP_001926.2	DPPIV_rep	38..58	CDD:465875	4/19 (21%)
		DPPIV_N	108..478	CDD:395744	128/426 (30%)
		Peptidase_S9	559..763	CDD:459761	79/204 (39%)