DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17684 and DPP4

DIOPT Version :9

Sequence 1:	NP_001015352.3	Gene:	CG17684 / 3355066	FlyBaseID:	FBgn0263780	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_001926.2	Gene:	DPP4 / 1803	HGNCID:	3009	Length:	766	Species:	Homo sapiens

Alignment Length:	826	Identity:	246/826 - (29%)
Similarity:	411/826 - (49%)	Gaps:	97/826 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 WRSIILSLLVISFVVSGIVTAIYLLGY-VDELLYWSGRRMILDEYLQGDLIPRRLPSSWVTTQKY 108
            |: ::|.||..:.:|:.|...:.||.. .|:....|.:...|.:||:.....:.....|::..:|
Human     5 WK-VLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEY 68

  Fly   109 VFQSDDGSLAVLDTTTNLVKVLVTNHTLRQL--NVRRYLCSSDLKYVLFTHNVKKNFQKSFTAFY 171
            :::.:: ::.|.:.......|.:.|.|..:.  ::..|..|.|.:::|..:|..|.::.|:||.|
Human    69 LYKQEN-NILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASY 132

  Fly   172 TIYDVTNDHHTPVKLKDTLKVQR--TRLQYASWLGNTTAIIFVVKNDIFIRQSPLVEEDIRITSS 234
            .|||:..        :..:..:|  ...|:.:|......:.:|..|||:::..|.: ...|||.:
Human   133 DIYDLNK--------RQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNL-PSYRITWT 188

  Fly   235 GHENHIYNGVPDWLYQEEIFETPEAIWTSSDGTHFMYALFNDTNVGMMTYPWLSSGALFSGSGIF 299
            |.|:.||||:.||:|:||:|....|:|.|.:||...||.||||.|.::.|.:.|..:|
Human   189 GKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESL------- 246

  Fly   300 SGSIFPETKMVRFPTPGTTNPEVELWAVD------ITNLSDIQKFNIKPPATIYGQDYYLTSAGW 358
               .:|:|..|.:|..|..||.|:.:.|:      :||.:.||   |..||::...|:||....|
Human   247 ---QYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQ---ITAPASMLIGDHYLCDVTW 305

  Fly   359 ISDSNCQVSVVYMGRSQNYSVISLCSKEED---WKCL--EVHSERAPEDEWLDIF----PHPVFS 414
            .:..  ::|:.::.|.|||||:.:|..:|.   |.||  ..|.|.:... |:..|    ||  |:
Human   306 ATQE--RISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTG-WVGRFRPSEPH--FT 365

  Fly   415 SDGSSFLFLANIQESENYQFTHIKHVMISQRRISVISHGRYEVTKI--LCWDTINHKVYFMATQD 477
            .||:||..:  |...|.|:  ||.:..|.::..:.|:.|.:||..|  |..|.:    |:::.:.
Human   366 LDGNSFYKI--ISNEEGYR--HICYFQIDKKDCTFITKGTWEVIGIEALTSDYL----YYISNEY 422

  Fly   478 K-KPGQRHLYSVQDPIHDDIRKVEPQCITCDLGDDLWSSRYYYTNCTHFEAFITPSLGVATNYGI 541
            | .||.|:||.:|   ..|..||  .|::|:|..:         .|.::        .|:.:...
Human   423 KGMPGGRNLYKIQ---LSDYTKV--TCLSCELNPE---------RCQYY--------SVSFSKEA 465

  Fly   542 EFYILECQGPGLPVSGVHMQTTHSLVKILYDTRPFYTERLQKLALPTQRSFEVPLPHGGRAQVQL 606
            ::|.|.|.|||||:..:|.......:::|.|.... .:.||.:.:|::: .:..:.:..:...|:
Human   466 KYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSAL-DKMLQNVQMPSKK-LDFIILNETKFWYQM 528

  Fly   607 LLPPSWREELRDAAFPVIVEVNGRPGSESVSEKFKIDWGTYMSSRNDVVYIRLDVRGSKGQSKKT 671
            :|||.:.:..:   :|::::|...|.|:.....|:::|.||::|..:::....|.|||..|..|.
Human   529 ILPPHFDKSKK---YPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKI 590

  Fly   672 LY---RHLGGVEVLDQISVIGYLLDTIGFLDETRVGMWGWGYGGYVTSMALGTQQDVFKCGIAVS 733
            ::   |.||..||.|||.. ......:||:|..|:.:|||.||||||||.||:...||||||||:
Human   591 MHAINRRLGTFEVEDQIEA-ARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVA 654

  Fly   734 PTADWLY--STFTERILGLPA--ENFKGYVEADATQRARLIKSNSYFLIHGLADTTAPFVHGVQL 794
            |.:.|.|  |.:|||.:|||.  :|...|..:....||...|...|.||||.||....|....|:
Human   655 PVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQI 719

  Fly   795 AKSLTSANILFRYQTYADEGHDL--SGVLEHVYSSMEQYFAECLSL 838
            :|:|....:.|:...|.||.|.:  |...:|:|:.|..:..:|.||
Human   720 SKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSL 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17684	NP_001015352.3	DPPIV_N	147..554	CDD:279298	128/426 (30%)
CG17684	NP_001015352.3	Abhydrolase	643..836	CDD:304388	78/201 (39%)
DPP4	NP_001926.2	DPPIV_N	108..478	CDD:279298	128/426 (30%)
		DAP2	<398..764	CDD:224423	124/397 (31%)
		Peptidase_S9	559..763	CDD:278741	79/204 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		otm41514
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.720