DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17684 and dpf-1

DIOPT Version :9

Sequence 1:	NP_001015352.3	Gene:	CG17684 / 3355066	FlyBaseID:	FBgn0263780	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_506850.1	Gene:	dpf-1 / 180042	WormBaseID:	WBGene00001054	Length:	799	Species:	Caenorhabditis elegans

Alignment Length:	844	Identity:	211/844 - (25%)
Similarity:	352/844 - (41%)	Gaps:	131/844 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 IILSLLVISFVVSGIVTAIYLLGYVDELLYWSGRRMILDEYLQGDLIPRRLP---SSWVTTQKYV 109
            ::|.:||:.|......|.::.     ...:.|.|..:      .||...|.|   .::......|
Worm    34 VVLLILVMIFAALVFFTPLFA-----AKSFGSWRLNV------SDLRSLRYPYAEFAFTDNNAVV 87

  Fly   110 FQSDDGSLAVLDTTTNLVKVLVTNHTLRQLNVRRYLCSSDLKY-VLFTHNVKKNFQKSFTAFYTI 173
            .||.:|...|.|..:.|:        ..:.|......|:|.|| .:..|............|:..
Worm    88 MQSWEGVEIVEDGVSRLI--------FGRENGAEITPSADRKYFAMMDHAPNPGMNPQNETFHLK 144

  Fly   174 YDVTNDHHTPV----------KLKDT-------LKVQRTRLQYASWLGNTTAIIFVVKNDIFIRQ 221
            ....|:...|:          :|.|:       |:.:.:.:|...|.|.....:||..|.|:.:.
Worm   145 IVNNNERLNPLLPFEVEELFRELSDSRITYDIGLRKEESVIQAFKWNGKFNDFVFVESNKIYYQS 209

  Fly   222 SPLVEEDIRITSSGHENHIYNGVPDWLYQEEIFETPEAIWTSSDGTHFMYALFND---TNVGMMT 283
            || .||.:...|:|.| |..:|:.||:|:||||...:|:|.|:.|....||.:::   .||.:.|
Worm   210 SP-EEEGLTRVSNGGE-HTVDGLFDWIYEEEIFGRKDAMWWSTKGDQLAYASYDNHLTKNVSLKT 272

  Fly   284 YPWLSSGALFSGSGIFSGSIFPETKMVRFPTPGTTNPEVELW--AVDITNLSDIQKFNIKPPATI 346
            |..|..      ..|.:...:|:|.....||     ..:.:|  ..:.:...|:|   :|...:.
Worm   273 YHRLEP------YPIDTNFHYPKTFAKVLPT-----YTLSIWNKKTEQSRQLDVQ---LKDSLSY 323

  Fly   347 YGQDYYLTSAGWIS-DSNCQVSVVYMGRSQNYSVISLCSKEEDWK---C-LEVHSERAPEDEWL- 405
                :||.:..|:. :...|:..|:..|.||...:::|    ||.   | ||...:.|.: .|:
Worm   324 ----HYLLAVKWLEINGTEQLVSVWTNRYQNEVALTIC----DWDTAICRLEFEYKYASK-RWVT 379

  Fly   406 -DIFPHPVFSSDGSSFLFLANIQESENYQFTHIKHVMISQ---RRISVISHGRYEVTKILCWDTI 466
             |.| |.:.|.:.:.|..|.:  :..:..|..:..:.:|.   |....::.|.|:||.|...:..
Worm   380 HDDF-HSITSFEDTLFFLLPH--DKRDNAFQQVASLRLSHGQLRTPKFLNLGEYDVTSINGINKE 441

  Fly   467 NHKVYFMATQDKKPGQRHLYSVQDPIHDDIRKVEPQCITCDLGDDLWSSRYYYTNCTHFEAFITP 531
            ...::|.|.. .||..|.|:|..  :.|:.|. ...||:|.:           .|||..:|.:..
Worm   442 TRTIFFHAAA-PKPSHRSLFSYS--LADESRN-SAYCISCSI-----------KNCTWAQAQMDD 491

  Fly   532 SLGVATNYGIEFYILECQGPGLPVSGV--------HMQTTHSLVKILYDTRPFYTERLQKLALPT 588
            .:..|        |:.|:||..|.:.:        ..:|.|:  .:|||..  |..|:::..||.
Worm   492 QMKTA--------IVSCKGPAAPHTAIVNLTRMDSDKKTEHA--NLLYDKT--YQNRVEEAGLPV 544

  Fly   589 QRSFEVPLPHGGRAQVQLLLPPSWREELRDAAFPVIVEVNGRPGSESVSEKFKIDWGTYMSSRND 653
            .....:.:.....|.::|.:|.......:..|.|:||.|.|.|..::..|..:|.....::|.:.
Worm   545 IIKETIKISDDFDALIKLSIPKDIYNRDKHQAIPLIVHVYGGPNDQNTKEATQIGIEEVVASASQ 609

  Fly   654 VVYIRLDVRGSKGQS---KKTLYRHLGGVEVLDQISVIGYLLDTI-GFLDETRVGMWGWGYGGYV 714
            ...:|:|.|||.|:.   :..:|..||.|||.|||..|..:|... ..||..||.::||.|||::
Worm   610 AAILRIDGRGSGGRGWKYRSAIYGQLGTVEVEDQIKAIKVVLRLYRHLLDARRVAVFGWSYGGFM 674

  Fly   715 T-SMALGTQQDVFKCGIAVSPTADWLY--STFTERILG-LPAENFKGYVEADATQRARLIKSNSY 775
            | ||.....:..|||.::|:|..::.|  :|:|||.:| .|.|::     :|.|::....||...
Worm   675 TLSMVNEAPEQFFKCAVSVAPVTNFAYYDATYTERYMGDAPLESY-----SDVTKKLDNFKSTRL 734

  Fly   776 FLIHGLADTTAPFVHGVQLAKSLTSANILFRYQTYADEGHDLSGVLEHVYSSMEQYFAECLSLD 839
            .|:|||.|....|.:...|...|.:..:.|....|.::.|.||....||...|..:..:|...|
Worm   735 LLMHGLLDDNVHFQNSAILIDELQNRGVDFDLMVYPNQAHSLSSRTSHVVGKMTHFLRQCFYTD 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17684	NP_001015352.3	DPPIV_N	147..554	CDD:279298	105/439 (24%)
CG17684	NP_001015352.3	Abhydrolase	643..836	CDD:304388	63/200 (32%)
dpf-1	NP_506850.1	DPPIV_N	182..507	CDD:279298	94/375 (25%)
		DAP2	<524..798	CDD:224423	84/282 (30%)
		Peptidase_S9	615..795	CDD:278741	61/184 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	157	1.000	Domainoid score	I2534
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	256	1.000	Inparanoid score	I1947
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46052
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		mtm8410
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	O	PTHR11731
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.980