DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17684 and dpp4

DIOPT Version :9

Sequence 1:	NP_001015352.3	Gene:	CG17684 / 3355066	FlyBaseID:	FBgn0263780	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_001154809.1	Gene:	dpp4 / 100301982	ZFINID:	ZDB-GENE-081104-277	Length:	742	Species:	Danio rerio

Alignment Length:	805	Identity:	241/805 - (29%)
Similarity:	405/805 - (50%)	Gaps:	95/805 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LVISFVVSGIVTAIYLLGYVDELLYWSGRRMILDEYLQGDLIPRRLPSSWVTTQKYVFQSDDGSL 117
            :|:..|:..:.|||.|.....|    ..:...|::|..|....:.....||:..:|..::.:||:
Zfish    13 VVVIVVLIAVPTAILLKEDKSE----PQKTFTLEDYFNGTGRTKSYNMRWVSDDEYFHKTGEGSV 73

  Fly   118 AVLDTTTNLVKVLVTNHTLRQLNVRRYLCSSDLKYVLFTHNVKKNFQKSFTAFYTIYDVTNDHHT 182
            .:.:.||......|......::....||.|:|.|||.|..|..|.::.::||.|:|||
Zfish    74 FLFNATTGNGNEFVNQQIFARVAAFDYLVSADRKYVCFLSNYTKLWRHTYTASYSIYD------- 131

  Fly   183 PVKLKDTLKVQRTR-LQYASWLGNTTAIIFVVKNDIFIRQSPLVEEDIRITSSGHENHIYNGVPD 246
             ::.:|.:...... :||.:|......:.||.|.:::::::| .....::|::|..|.|.|||||
Zfish   132 -LEKRDFINTDIPHDVQYLAWSPTGHKLAFVWKYNVYVKETP-NSAFKQVTTNGAHNLILNGVPD 194

  Fly   247 WLYQEEIFETPEAIWTSSDGTHFMYALFNDTNVGMMTYPWLSSGALFSGSGIFSGSIFPETKMVR 311
            |:|:||:|.|..|:|.|.:|....||.|||:.|..:.|.|...|.            :|||..|.
Zfish   195 WVYEEEMFSTNSALWWSPNGRFVAYAEFNDSEVHNIEYTWFGEGQ------------YPETVFVP 247

  Fly   312 FPTPGTTNPEVELWAVDITNLSDIQKFNIKPPATIYGQDYYLTSAGWISDSNCQVSVVYMGRSQN 376
            :|..||.||.|:|:..| ||.:.|::.::  |:.:...::||::..|.||.  :::|.:..|:||
Zfish   248 YPKAGTPNPTVKLFVFD-TNTNTIKQVSV--PSDVGAGEHYLSTVTWASDH--RIAVQWQKRTQN 307

  Fly   377 YSVISLCS-KEEDWKCLEVHSERAPEDEWLDIF--PHPVFSSDGSSFLFLANIQESENYQFTHIK 438
            |.|:.... .:.:|....:.........|:..|  ..|||..||:|..::.    |.:.:|.|:.
Zfish   308 YVVLETYDFNDGNWTEGSLSQIITSSTGWVGRFSPDEPVFRPDGNSCYYIL----SNDERFKHLA 368

  Fly   439 HVMISQRRISVISHGRYEVTKILCWDTINHKVYFMATQ-DKKPGQRHLY--SVQDPIHDDIRKVE 500
            :.:.:||  ..::.|::||..||  ...|:.:||::.: ::.||||::|  ::....|.|
Zfish   369 YFIGTQR--IFLTRGKWEVISIL--KVTNNALYFVSNEHNESPGQRNVYKITINGASHSD----- 424

  Fly   501 PQCITCDLGDDLWSSRYYYTNCTHFEAFITPSLGVATNYGIEFYILECQGPGLPVSGVHMQTTHS 565
            .:|:||.|..|    |..|.:.|    |.|..         .:|::.|.|||||:  ..::.:.:
Zfish   425 RECLTCTLNAD----RCKYNSAT----FSTEG---------SYYLMSCSGPGLPL--YTLRNSQA 470

  Fly   566 LVKILYDTRPFYTERLQKLALPTQRSFEVPLPHGGRAQV-------QLLLPPSWREELRDAAFPV 623
            .:::| :.......:||::|:|:...        |:.::       |::|||.:.:..:   :|:
Zfish   471 ELRVL-ENNSVLEHKLQEIAMPSNMY--------GKLKIGEFDLWYQMILPPRFDKSKK---YPL 523

  Fly   624 IVEVNGRPGSESVSEKFKIDWGTYMSSRNDVVYIRLDVRGSKGQSKK---TLYRHLGGVEVLDQI 685
            :::|...|.|:....:|::.|.||::|...|:....|.|||..|..:   .||:.||..||.|||
Zfish   524 LIDVYAGPCSQKSDFRFRVGWSTYLASTERVIVASFDGRGSGYQGDQIMHALYKRLGTYEVEDQI 588

  Fly   686 SVIGYLLDTIGFLDETRVGMWGWGYGGYVTSMALGTQQDVFKCGIAVSPTADWLY--STFTERIL 748
            :.....:| :||:|::|:.:|||.||||||||.||....|||||:||:|.:.|.|  |.:|||.:
Zfish   589 TAARQFID-MGFIDKSRIAIWGWSYGGYVTSMVLGAGSGVFKCGMAVAPVSKWEYYDSIYTERYM 652

  Fly   749 GLPAENFKGYVEADATQRARLIKSNSYFLIHGLADTTAPFVHGVQLAKSLTSANILFRYQTYADE 813
            ..||||...|..:..|.||:..||..|.|:||.||....|....|::|:|....:.|....|.||
Zfish   653 LTPAENQAFYDNSTVTGRAKSFKSVQYLLVHGTADDNVHFQQAAQISKALVDEQVDFDTMWYTDE 717

  Fly   814 GHDLSG-VLEHVYSSMEQYFAECLS 837
            .|.|.| ..:|||:.|..:...|.:
Zfish   718 DHSLGGSANQHVYTHMTHFLKTCFA 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17684	NP_001015352.3	DPPIV_N	147..554	CDD:279298	121/413 (29%)
CG17684	NP_001015352.3	Abhydrolase	643..836	CDD:304388	82/198 (41%)
dpp4	NP_001154809.1	DPPIV_N	103..461	CDD:279298	121/413 (29%)
		FrsA	509..733	CDD:223999	89/227 (39%)
		Peptidase_S9	540..741	CDD:278741	83/201 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.720