DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17684 and fap

DIOPT Version :9

Sequence 1:	NP_001015352.3	Gene:	CG17684 / 3355066	FlyBaseID:	FBgn0263780	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_001107145.1	Gene:	fap / 100134993	XenbaseID:	XB-GENE-482832	Length:	755	Species:	Xenopus tropicalis

Alignment Length:	821	Identity:	243/821 - (29%)
Similarity:	406/821 - (49%)	Gaps:	112/821 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 ILSLLVISFVVSGIVTAIYLLGYVDELLYWSGRRMILDEYLQGDLIPRRLPSSWVTTQKYVFQSD 113
            |::||:::.|   :||:.:..|   :|..:|     .|:....::..:.....|::..:|:.::.
Frog    16 IVTLLIVTIV---LVTSGFSNG---DLKTFS-----FDDAFSQNVSYQTYHHLWISENEYIRKTS 69

  Fly   114 DGSLAVLDTTTNLVKVLVTNHTLRQLNVRRYLCSSDLKYVLFTHNVKKNFQKSFTAFYTIYDVTN 178
            ..:|.:.:..|.....:::|.:...:|...|:.|.|.::||...|.||.::.|:||.|.|||:.|
Frog    70 QNNLIIYNVETREASAILSNASFNSVNATNYILSYDRRFVLLESNYKKKWRYSYTASYHIYDIEN 134

  Fly   179 -----DHHTPVKLKDTLKVQRTRLQYASWLGNTTAIIFVVKNDIFIRQSPLVEEDIRITSSGHEN 238
                 ::..|           ..:||..|......:::|:.|:|::...| .:..|.:||.|.||
Frog   135 GRFVKENELP-----------PNIQYIHWAPKGHKLVYVLDNNIYLVYEP-GQTAIALTSDGKEN 187

  Fly   239 HIYNGVPDWLYQEEIFETPEAIWTSSDGTHFMYALFNDTNVGMMTYPWLSSGALFSGSGIFSGSI 303
            .||||:|||:|:|.:.....|.|.|.:|....|..|||..|.:|.|            ..:....
Frog   188 EIYNGIPDWVYEELMLGGNYATWWSPNGKFIAYVQFNDKEVPVMEY------------SFYGEDQ 240

  Fly   304 FPETKMVRFPTPGTTNPEVELWAVDITNLSDIQKFNIKPPATIYGQDYYLTSAGWISDSNCQVSV 368
            :|.|..:.:|..|..||.|:|:.|.:.:...|:...|:.|:.:...|||.:...|:.|.  :|||
Frog   241 YPRTMKISYPKAGAKNPTVKLFIVKVDDPDSIRTEQIQVPSLLASSDYYFSWVTWVLDE--RVSV 303

  Fly   369 VYMGRSQNYSVISLC---SKEEDWKC--LEVHSERAPEDEWLDIF--PHPVFSSDGSSFLFLANI 426
            .::.||||.|||::|   .:...|.|  .:.|.| ..|..|:.:|  |.|||:||..|:..:.
Frog   304 QWLPRSQNISVIAICDFKGRSNTWVCPKSQEHLE-ISETGWIGVFFPPLPVFTSDNLSYYQIL-- 365

  Fly   427 QESENYQFTHIKHVMISQRRISVISHGRYEVTKILCWDTINHKVYFMATQ-DKKPGQRHLYSV-- 488
              |:...:.||.::.....:...|:||.:|.  |..:...|..:|:.:.: ::.||:||:|.:
Frog   366 --SDQTGYKHIHYISDPGEKPLPITHGNWEA--IYIYLVTNEAIYYSSNEYEEAPGRRHIYRIGL 426

  Fly   489 QDPIHDDIRKVEPQCITCDLGDDLWSSRYYYTNCTHFEAFITPSLGVATNYGIEFYILECQGPGL 553
            |.|      :.|.|||||::..:  ..:||....:|               ..::|.|.|.|||:
Frog   427 QGP------QREKQCITCNVRRE--RCQYYTARFSH---------------KAKYYTLYCYGPGI 468

  Fly   554 PVSGVHMQTTHSLVKILYDTRPFYTERLQKLALPTQRSFEVPLPHGGRAQVQ--------LLLPP 610
            |:..:|...|:..::||.|     ...|:    .|.|:|::|....|:. ||        :.|||
Frog   469 PIVTLHEGFTNKEIQILED-----NSNLE----ATLRNFQMPSEKIGKI-VQNDKTFWYKMTLPP 523

  Fly   611 SWREELRDAAFPVIVEVNGRPGSESVSEKFKIDWGTYMSSRNDVVYIRLDVRGSKGQSKK---TL 672
            .:....:   :|:::.|.|.|.|:.|...|.:.:.||::|...::...||.||:..|..|   .:
Frog   524 HFNPRKK---YPLLIYVYGGPSSQEVKATFSVGYSTYLASTEGIIVASLDGRGTAYQGDKFMHAI 585

  Fly   673 YRHLGGVEVLDQISVIGYLLDTIGFLDETRVGMWGWGYGGYVTSMALGTQQDVFKCGIAVSPTAD 737
            |:.||.|||.|||......: |:||:||.|:.:|||.||||||||.||....:||||:||:|.::
Frog   586 YKKLGTVEVEDQIFAARKFI-TMGFIDEKRIAIWGWSYGGYVTSMVLGQGTGLFKCGMAVAPVSN 649

  Fly   738 WLY--STFTERILGLP--AENFKGYVEADATQRARLIKSNSYFLIHGLADTTAPFVHGVQLAKSL 798
            |.|  |.:|||.:|||  ::|.:.|..:....||...:...|.|:||.||....|....|::|:|
Frog   650 WEYYASIYTERYMGLPTKSDNLENYKNSTVMTRAEQFRKVDYLLVHGTADDNVHFQQAAQISKAL 714

  Fly   799 TSANILFRYQTYADEGHDLSGVLE-HVYSSMEQYFAECLSL 838
            ..|.:.|:...|.|:.|.|||..: |:::.|..:..:|.:|
Frog   715 VEAQVDFQAMWYTDKDHSLSGSAKTHLFTHMTHFLKQCFNL 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17684	NP_001015352.3	DPPIV_N	147..554	CDD:279298	123/421 (29%)
CG17684	NP_001015352.3	Abhydrolase	643..836	CDD:304388	77/200 (39%)
fap	NP_001107145.1	DPPIV_N	103..469	CDD:366374	123/421 (29%)
fap	NP_001107145.1	Peptidase_S9	550..754	CDD:366030	79/204 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		otm48727
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920