DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17684 and dpp6a

DIOPT Version :9

Sequence 1:	NP_001015352.3	Gene:	CG17684 / 3355066	FlyBaseID:	FBgn0263780	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_009295542.1	Gene:	dpp6a / 100007104	ZFINID:	ZDB-GENE-090918-4	Length:	810	Species:	Danio rerio

Alignment Length:	838	Identity:	251/838 - (29%)
Similarity:	412/838 - (49%)	Gaps:	122/838 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 NWRSIILSLLVISFVVSGIVTAIYLL--GYVDELLYWSGRRMILDEYLQGDLIPRRLPSSWVTTQ 106
            ||:.|.::||||..:.|.|||::.||  |..|.|.:  ..::.::|..:.|.......:.|::..
Zfish    40 NWKGIAIALLVILVICSLIVTSVILLTPGEDDSLAF--KEKVTVEEIFKKDFKVHDPNAKWISNN 102

  Fly   107 KYVFQSDDGSLAVLDTTTNLVKVLVTNHTLRQLNVRRYLCSSDLKYVLFTHNVKKNFQKSFTAFY 171
            :.::::.:|.:...:..||...:||||.........:|..|.|:|.||..:||:..::.||||.|
Zfish   103 ELLYRTREGDVVRFNMETNESTILVTNRKFEMYKASKYEVSPDMKLVLLAYNVQLVYEHSFTADY 167

  Fly   172 TIYDVTNDHHTP-VKLKDTLKVQRTRLQYASWLGNTTAIIFVVKNDIFIRQSPLVEEDIRITSSG 235
            .|..:    .|| ..:.:..:|:...||||.|......:||:.:|:|:.| :.:....||:.|:|
Zfish   168 IICSL----ETPETWILNPPEVRNAHLQYAGWGPRGQQLIFIFENNIYYR-ATVENRSIRLVSTG 227

  Fly   236 HENHIYNGVPDWLYQEEIFETPEAIWTSSDGTHFMYALFNDTNVGMMTYPWLSSGALFSGSGIFS 300
            .|..|:||:.||||:.|||::..|.|.|.||....||..|||.|..|..|            :|:
Zfish   228 KEGVIFNGLTDWLYEAEIFKSHIAHWWSPDGARLAYATINDTLVPRMEIP------------MFT 280

  Fly   301 GSIFPETKMVRFPTPGTTNPEVELWAVDITNLSDIQKFNIKPPATIYGQDYYLTSAGWISDSNCQ 365
            ||::|..:...:|..|..||.:.|:.|::.  ..:....::.|......:||:|...|.:.:  :
Zfish   281 GSLYPTARQYHYPKAGEENPVISLYVVNLN--GPLHTIEMRRPEDQRIGEYYVTMVKWATST--K 341

  Fly   366 VSVVYMGRSQNYSVISLCSKEEDWKCLEVHSERAPEDE---WLDIFPH-----PVFSSDGSSFLF 422
            ::|.::.|:||.|:::||..... .|.:.|     |||   ||    |     |:||.||....|
Zfish   342 LAVNWLNRAQNISILTLCVATTG-VCTKKH-----EDESEGWL----HRQNEEPLFSKDGLRLFF 396

  Fly   423 LANIQESENYQFTHIKHVMISQRRISV-----ISHGRYEVTKILCWDTINHKVYFMATQDKKPGQ 482
            ...|.:....:|.||. :.|||...|.     |:.|.::||::|.:|..:..:||::|:| .|.:
Zfish   397 TRAIPQGGRGKFFHIS-MSISQPNSSTDTLQSITSGDWDVTQVLAYDEESQLIYFLSTED-DPKR 459

  Fly   483 RHLYSVQDPIHDDIRKVEPQCITCDLGDDLWSSRYYYTNCTHFEAFITPSLGVATNYGIEFYILE 547
            |||||.     |.:.....:|::||..|          :|.:.....:|::        ::::|.
Zfish   460 RHLYSA-----DTVGTFNRRCLSCDFTD----------SCGYVSGSFSPTM--------DYFLLN 501

  Fly   548 CQGPGLPVSGVHMQTTHSLVKILYDTRPFYTERLQKLALPTQ-----RSFEVPLPHGGRAQ---- 603
            |:|||:|.:.|:  :||            |.:::|.:.|...     .|.::|     |.:
Zfish   502 CKGPGVPYAAVY--STH------------YRQKVQDIELNLNLRRKVNSMQMP-----RVEYREI 547

  Fly   604 --------VQLLLPPSWREELRDAAFPVIVEVNGRPGSESVSEKFKIDWGTYMSSRNDVVYIRLD 660
                    ||:|.|..:   :..:.:|:::.|:|.|||:||||:|.|||.:.:.|...||.:|.|
Zfish   548 NIEDYSLSVQILKPAGF---IDTSHYPLLLLVDGTPGSQSVSEQFHIDWASVLVSSFGVVAVRFD 609

  Fly   661 VRGSKGQSKKTLY---RHLGGVEVLDQISVIGYLLDTIGFLDETRVGMWGWGYGGYVTSMALGTQ 722
            .|||..|....|:   |.||..|..||:.|:..::.. .::|:||:|.:|..||||:||:.|.::
Zfish   610 GRGSGFQGTNLLHKVQRRLGMFEEKDQLDVLSIMMQE-QYIDKTRIGAFGQVYGGYITSLLLSSE 673

  Fly   723 QDVFKCGIAVSPTADW-LY-STFTERILGLPAENFKGYVEADATQRARLIKSNSYFLIHGLADTT 785
            ..:.||...:||..|: || |.|:||.||.|..:.:.|..|:...||.......:.:||..||..
Zfish   674 DSMLKCAAVLSPITDFALYASAFSERYLGPPKPDRRAYEMANLAYRASQFIDKKFLIIHPTADEK 738

  Fly   786 APFVHGVQLAKSLTSANILFRYQTYADEGHDLSGVL--EHVYSSMEQYFAECLSLDPD 841
            ..|.|..:....|.|....:..|.|.||||.:...|  :|:..|:..:|.||..| ||
Zfish   739 VHFQHTAKFISRLISERANYSLQIYPDEGHFIHNELTRQHLSQSLVNFFEECFRL-PD 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17684	NP_001015352.3	DPPIV_N	147..554	CDD:279298	126/420 (30%)
CG17684	NP_001015352.3	Abhydrolase	643..836	CDD:304388	68/199 (34%)
dpp6a	XP_009295542.1	DPPIV_N	143..509	CDD:279298	126/421 (30%)
dpp6a	XP_009295542.1	Abhydrolase	589..791	CDD:304388	70/202 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	181	1.000	Domainoid score	I3415
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	O	PTHR11731
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.920