Protein Alignment Haspin and HASPIN

DIOPT Version :9

• Sequence 1: NP_001015349.2
• Gene: Haspin / 3355064
• FlyBaseID: FBgn0046706
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_114171.2
• Gene: HASPIN / 83903
• HGNCID: 19682
• Length: 798
• Species: Homo sapiens
• Alignment Length: 598
• Identity: 182/598 - (30%)
• Similarity: 268/598 - (44%)
• Gaps: 130/598 - (21%)

  Fly    83 DSISTPCDKRLGGTTGLFETDLSPITRLKLEGV----------EDSRDKCADTNEADLYVNVEIL 137
            |..|.||.:. ..|.|..:|.:...||..|..|          |||..:....|..:.....:::
Human   213 DRASLPCSQE-EATGGAKDTRMVHQTRASLRSVLFGLMNSGTPEDSEFRADGKNMRESCCKRKLV 276

  Fly   138 FQNINSSPKKCSNFGKKRLS--------NLNKMVTAVHPSISLNPGK--------------WRKS 180
            ..|....| ..|:.||:|.:        .|.:.|...|...|:..|:              .|||
Human   277 VGNGPEGP-GLSSTGKRRATGQDSCQERGLQEAVRREHQEASVPKGRIVPRGIDRLERTRSSRKS 340

  Fly   181 LNNFIRSKITETNFT-----KKVER-----------------------RSSICQDRKSLV----- 212
            .:    .:.|||:..     ||.::                       |:|....:|.:|
Human   341 KH----QEATETSLLHSHRFKKGQKLGKDSFPTQDLTPLQNVCFWTKTRASFSFHKKKIVTDVSE 401

  Fly   213 ----------LKGE---------------------H-------------KFENKYEEDVLKY--- 230
                      |.|.                     |             ...||...|..|.
Human   402 VCSIYTTATSLSGSLLSECSNRPVMNRTSGAPSSWHSSSMYLLSPLNTLSISNKKASDAEKVYGE 466

  Fly   231 CHQCTPLPFNTAYEQHKLLNTKKIGEGAYGEVFRCSRNQEVLKDHISDIVLKIIPLEGSTVINGE 295
            |.|..|:||:......||...:|||||.:||||      :.:.|| :.:.:|||.:||..::||.
Human   467 CSQKGPVPFSHCLPTEKLQRCEKIGEGVFGEVF------QTIADH-TPVAIKIIAIEGPDLVNGS 524

  Fly   296 KQKTFSQILPEIIITKKMCSLRTSKTNSTNGFVSIQKVSLVKGRYPPHFIKLWEKYDNEKGSEND 360
            .||||.:|||||||:|::..|.....|.|.||:.:..|..|:|.|||..:|.|:.|::.|||.||
Human   525 HQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSAND 589

  Fly   361 HPELFGDNQLFAVLELKFAGSDMANF--KFLNSEQSYYALQQIILALAVGEEEYQFEHRDLHLGN 423
            .|:.|.|:|||.|||.:|.|.|:...  |..:...:...|.|:..:|||.|...:|||||||.||
Human   590 RPDFFKDDQLFIVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGN 654

  Fly   424 ILIEYTNKKHIVCTFKSSNLTLLSKGVNVTIIDYTLSRVTINDCCYFNDLSRDEELFQATGDYQY 488
            :|::.|:.|.:..|....:.|:.|.|:.|:||||||||:..:....|.|:|.||:||...||||:
Human   655 VLLKKTSLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQF 719

  Fly   489 DVYRMMRNELKNNWSSFSPKTNIIWLSYVIVKVLDSVKYKS-INTKVHRMYIDKIKELKNIIMTF 552
            |:||:|:.|..|.|..:.|.:|::||.|:..|:|..:.:|: .||...:....||:|....::.|
Human   720 DIYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQIKRKIQEFHRTMLNF 784

  Fly   553 ESASH--CANYLF 563
            .||:.  |.:.||
Human   785 SSATDLLCQHSLF 797

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Haspin	NP_001015349.2	PKc_like	252..>426	CDD:304357	77/175 (44%)
		DUF3635	479..>545	CDD:289128	25/66 (38%)
HASPIN	NP_114171.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..110
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	275..350		17/79 (22%)
		ALK1	322..778	CDD:227404	150/466 (32%)
		PKc_like	488..>655	CDD:304357	76/173 (44%)
		DUF3635	710..790	CDD:289128	29/79 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153082
Domainoid	1	1.000	254	1.000	Domainoid score	I2070
eggNOG	1	0.900	-	-		E1_COG5072
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6322
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003225
OrthoInspector	1	1.000	-	-		oto88440
orthoMCL	1	0.900	-	-		OOG6_104891
Panther	1	1.100	-	-	LDO	PTHR24419
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R550
SonicParanoid	1	1.000	-	-		X4233
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.680