DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Haspin and Haspin

DIOPT Version :9

Sequence 1:	NP_001015349.2	Gene:	Haspin / 3355064	FlyBaseID:	FBgn0046706	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_172416.2	Gene:	Haspin / 837468	AraportID:	AT1G09450	Length:	599	Species:	Arabidopsis thaliana

Alignment Length:	596	Identity:	163/596 - (27%)
Similarity:	263/596 - (44%)	Gaps:	145/596 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ISKTKM----DFLEEGRWKDPFD--ELLD---SRTKLSKMNIVKQNVRVTYNIDSSVENSSYIEI 59
            |.|.|:    ||.:|..:....|  |||:   |..|.|...:.:|.|....::.:.:|  .::..
plant    97 IPKGKVVKAPDFQKEKEYFRDIDAFELLEESPSPNKSSTWTMGEQVVPEMPHLSTRLE--KWLIS 159

  Fly    60 KEPNHKNEPLT-----LEDCSI--KVYCPSD-----SISTPCDKRLGGTTGLF------ETDLS- 105
            |:.||...|.:     ||:.:|  :..|.:|     |:.|| ||...|.|.:|      :.:|:
plant   160 KKLNHTCGPSSTLSKILENSAIHQESVCDNDAFDSLSLKTP-DKSSAGNTSVFRLIPSCDENLAA 223

  Fly   106 ---PITRLKLEGVEDSRDKCADTNEADLYVNVEILFQNINSSPKKCSNFGKKRLSNLNKMVTAVH 167
               |:.::|:|.: |..|:.                               ||||
plant   224 EDVPVRKIKMESI-DLEDEL-------------------------------KRLS---------- 246

  Fly   168 PSISLNPGKWRKSLNNFIRSKITETNFTKKVERRSSICQDRKSLVLKGEHKFENKYEEDVLKYCH 232
                             :.|.:..|:            ||....:|            |:|..|.
plant   247 -----------------LTSDLIPTH------------QDFDQPIL------------DLLSACG 270

  Fly   233 QCTPLPFNTAY----EQHKLLNTKKIGEGAYGEVFRCSRNQEVLKDHISDIVLKIIPLEGSTVIN 293
            |..|..|..|:    |...::   |||||.|||.||...:           |.||:|::|...:|
plant   271 QMRPSNFIEAFSKFCEPESIV---KIGEGTYGEAFRAGSS-----------VCKIVPIDGDFRVN 321

  Fly   294 GEKQKTFSQILPEIIITKKMCSLRTSKTNSTN---GFVSIQKVSLVKGRYPPHFIKLWEKYDNEK 355
            ||.||...::|.|:|::..:..||..:|.:.|   .::..|.:.|.:|.|.|..||.||::|.:.
plant   322 GEVQKRADELLEEVILSWTLNQLRECETTAQNLCPTYIKTQDIKLCQGPYDPILIKAWEEWDAKH 386

  Fly   356 GSENDHPELFGDNQLFAVLELKFAGSDMANFKFLNSEQSYYALQQIILALAVGEEEYQFEHRDLH 420
            |||||||: |.:.|.:.:..|:..|.|:.:|..||.:::...|.|....|||.|..::|||||||
plant   387 GSENDHPD-FPEKQCYVMFVLEHGGKDLESFVLLNFDEARSLLVQATAGLAVAEAAFEFEHRDLH 450

  Fly   421 LGNILIEYTNKKHIVCTFKSSNLTLLSKGVNVTIIDYTLSRVTINDCCYFNDLSRDEELFQA-TG 484
            .||||:...|...:....:...:.:.:.||.::|||:||||:...:...|.||:.|..||:. .|
plant   451 WGNILLSRNNSDTLPFILEGKQVCIKTFGVQISIIDFTLSRINTGEKILFLDLTSDPYLFKGPKG 515

  Fly   485 DYQYDVYRMMRNELKNNWSSFSPKTNIIWLSYVIVKVLDSVKYKSINTKVHRMYIDKIKELKNII 549
            |.|.:.||.|:...::.|.....:||::||.| :|.:|.:.|....::|..|    :::.||..:
plant   516 DKQSETYRKMKAVTEDYWEGSFARTNVLWLIY-LVDILLTKKSFERSSKHER----ELRSLKKRM 575

  Fly   550 MTFESASHCAN 560
            ..:|||....:
plant   576 EKYESAKEAVS 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Haspin	NP_001015349.2	PKc_like	252..>426	CDD:304357	68/176 (39%)
Haspin	NP_001015349.2	DUF3635	479..>545	CDD:289128	19/66 (29%)
Haspin	NP_172416.2	PKc_like	265..586	CDD:419665	102/328 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	187	1.000	Domainoid score	I982
eggNOG	1	0.900	-	-		E1_COG5072
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	190	1.000	Inparanoid score	I1389
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1374355at2759
OrthoFinder	1	1.000	-	-		FOG0003225
OrthoInspector	1	1.000	-	-		oto3731
orthoMCL	1	0.900	-	-		OOG6_104891
Panther	1	1.100	-	-	LDO	PTHR24419
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4233
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.830