Protein Alignment Haspin and Irak3

DIOPT Version :10

• Sequence 1: NP_001015349.2
• Gene: Haspin / 3355064
• FlyBaseID: FBgn0046706
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_082955.2
• Gene: Irak3 / 73914
• MGIID: 1921164
• Length: 609
• Species: Mus musculus
• Alignment Length: 530
• Identity: 94/530 - (17%)
• Similarity: 167/530 - (31%)
• Gaps: 174/530 - (32%)

  Fly    89 CDKRLGGTTGLFETDLSPITRLKLEGVEDSRD--------------KCADTNEADLYVNV----- 134
            |..|...:..|...||.|....:|.|:.||.|              ...|....:.|||.
Mouse     5 CGARGALSPQLLLFDLPPALLGELCGILDSCDGPLGWRGLAERLSNSWLDVRHIEKYVNQGKSGT 69

  Fly   135 -EILF------QNINSSPKKCSNFGKKRLSNLNKMVTAVHPSISLNPG-KWRKSLNNFIRSKITE 191
             |:|:      :.|....:...:.|.:|         |:|  :.:|.| .|..|:..  ..::..
Mouse    70 RELLWSWAQKNKTIGDLLEVLQDMGHQR---------AIH--LIINYGVSWTPSVQT--HHELPF 121

  Fly   192 TNFTKKVERRSSICQDRK-----------SLVLKGEHKFENKYEEDVLKYCHQCTPLPFNTAYEQ 245
            .:|..:|:.   .|::..           ..||..||.     |:..|    |.||:.|.:..|.
Mouse   122 PSFPPEVKH---ACRENDPGPLEPANVTVDNVLVPEHN-----EKGTL----QKTPISFQSILEG 174

  Fly   246 HKLLNTK-KIGEGAYGEVFRCS-RNQEVLKDHISDIVLKIIPLEGSTVINGEKQKTFSQILPEII 308
            .|..:.. .||||...||:|.. |||.        ..:|:...|....:....::..|::  |::
Mouse   175 TKHFHKDFLIGEGEIFEVYRVDIRNQA--------YAVKLFKQEKKMQLKKHWKRFLSEL--EVL 229

  Fly   309 I----------------TKKMCSLRTSKTNSTNGFVSIQKVSLVKGRYPPHFIKLWEKYDNEKGS 357
            :                |:|:|.:....:|.|                      |:::.....|:
Mouse   230 LLFRHPHILELAAYFTETEKLCLVYPYMSNGT----------------------LFDRLQCTNGT 272

  Fly   358 ENDHPELFGDNQLFAVLELKFAGSDMANFKFLNSEQSYYALQQIILALAVGEEEYQFEHRDLHLG 422
                                             :..|::....:::.:|   :..|:.|.
Mouse   273 ---------------------------------TPLSWHVRISVLIGIA---KAIQYLHN----- 296

  Fly   423 NILIEYTNKKHIVCTFKSSNLTLLSKGVNVTIIDYTLSRVTINDCCYFNDLSRDEELFQATGDYQ 487
                  |....::|...||...||...:...:.|:..:....|       |.:.......||..:
Mouse   297 ------TQPCAVICGNVSSANILLDDQLQPKLTDFAAAHFRPN-------LEQQSSTINMTGGGR 348

  Fly   488 YDVYRMMRNELKNNWSSFSPKTNIIWLSYVIVKVLDSVKYKSINTKVHRMYIDKIKELKNIIMTF 552
            ..::.|....::.  ...|.||::.....||::||...|....:.| |....|.:.||    |..
Mouse   349 KHLWYMPEEYIRQ--GRLSVKTDVYSFGIVIMEVLTGCKVVLDDPK-HVQLRDLLMEL----MEK 406

  Fly   553 ESASHCANYL 562
            .....|.::|
Mouse   407 RGLDSCLSFL 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Haspin	NP_001015349.2	Protein Kinases, catalytic domain	225..547	CDD:473864	57/339 (17%)
Irak3	NP_082955.2	Death_IRAK-M	16..102	CDD:260062	19/96 (20%)
		PK_IRAK3	184..459	CDD:271062	53/326 (16%)