DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Haspin and haspin

DIOPT Version :9

Sequence 1:	NP_001015349.2	Gene:	Haspin / 3355064	FlyBaseID:	FBgn0046706	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	XP_017211541.2	Gene:	haspin / 557879	ZFINID:	ZDB-GENE-090313-379	Length:	1086	Species:	Danio rerio

Alignment Length:	335	Identity:	137/335 - (40%)
Similarity:	204/335 - (60%)	Gaps:	10/335 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 EDVLKYCHQCTPLPFNTAYEQHKLLNTKKIGEGAYGEVFRCSRNQEVLKDHISDIVLKIIPLEGS 289
            |.|.:.|.|..||.|:......::.:..|||||.:||||      ..:.|....:.|||||:|||
Zfish   749 EKVYQECQQSGPLSFSDCIPPARMKHLNKIGEGTFGEVF------STINDSNESVALKIIPVEGS 807

  Fly   290 TVINGEKQKTFSQILPEIIITKKMCSLRTSKTNSTNGFVSIQKVSLVKGRYPPHFIKLWEKYDNE 354
            ..:|||.||||.:||.||||:|::.||...:.|.::||:.:..:..|:|.||...:|.|:|:|::
Zfish   808 QQVNGEHQKTFGEILHEIIISKELSSLNLKEFNKSDGFIGLNNLHCVRGCYPEALLKAWDKFDHQ 872

  Fly   355 KGSENDHPELFGDNQLFAVLELKFAGSDMANF--KFLNSEQSYYALQQIILALAVGEEEYQFEHR 417
            ||||||.|:.|.|.|||.:||.:|.|||:.|.  |..:..|:...|.|:..:|||.|:...||||
Zfish   873 KGSENDRPDFFDDEQLFLILEFEFGGSDLENMNGKLSSMAQAKSVLHQVTASLAVAEQALCFEHR 937

  Fly   418 DLHLGNILIEYTNKKHIVCTFKSSNLTLLSKGVNVTIIDYTLSRVTINDCCYFNDLSRDEELFQA 482
            |||.||||::....||.......:...:.::||:|.||||:|||:.|:......|:|.|||||..
Zfish   938 DLHWGNILVKNVKHKHNEFILNGTVHCIETRGVHVNIIDYSLSRLEIDGLTVSCDISSDEELFMG 1002

  Fly   483 TGDYQYDVYRMMRNELKNNWSSFSPKTNIIWLSYVIVKVLDSVKYKS-INTKVHRMYIDKIKELK 546
            .||||:::||:|:.|.||.||:::|.:|::||.|:..|:| |:.|:: ..:...|.....:...|
Zfish  1003 QGDYQFEIYRLMKKENKNCWSAYNPHSNVLWLHYLADKLL-SMNYRNKTQSSQQRTLKSALNAFK 1066

  Fly   547 NIIMTFESAS 556
            :.||.:.||:
Zfish  1067 SEIMNYPSAT 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Haspin	NP_001015349.2	PKc_like	252..>426	CDD:304357	82/175 (47%)
Haspin	NP_001015349.2	DUF3635	479..>545	CDD:289128	24/66 (36%)
haspin	XP_017211541.2	DUF3635	<773..1071	CDD:331194	127/304 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	261	1.000	Domainoid score	I1927
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003225
OrthoInspector	1	1.000	-	-		oto41448
orthoMCL	1	0.900	-	-		OOG6_104891
Panther	1	1.100	-	-	LDO	PTHR24419
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R550
SonicParanoid	1	1.000	-	-		X4233
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.940