DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Haspin and Irak1

DIOPT Version :9

Sequence 1:	NP_001015349.2	Gene:	Haspin / 3355064	FlyBaseID:	FBgn0046706	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	XP_006229660.1	Gene:	Irak1 / 363520	RGDID:	1563841	Length:	711	Species:	Rattus norvegicus

Alignment Length:	349	Identity:	69/349 - (19%)
Similarity:	111/349 - (31%)	Gaps:	117/349 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 RLSNLNKMVTAVHPSISL----------------------NPGKWRKSLNNFIRSKITETNFTKK 197
            :|.....::||.||..|:                      :|.|.:.|.:.|:......:....:
  Rat    91 QLLRARDIITAWHPPASVLPPSTGAPRPSSISAGSETEDWSPRKLQSSASTFLSPAFPGSQTHSE 155

  Fly   198 VERRSSICQDRKSLVLKGE--HKFENKYEEDVLKYCHQCTPLPF---------NTAYEQHKLLNT 251
            .|.......|.....|:..  ...:....|..:....:..|.||         .|.....:|
  Rat   156 SELLQVPLSDSLGPPLQSSAPSSIKQPSPESPVSGLQRARPSPFCWPFCEISQGTCNFSEEL--- 217

  Fly   252 KKIGEGAYGEVFRC-SRNQ----EVLKDHISDIVLKIIPLEGSTVINGEKQKTFSQILPEIIITK 311
             :||||.:|.|:|. .||.    :.||:. :|:...::  :.|.:...|:...|..  |.|:...
  Rat   218 -RIGEGGFGCVYRAVMRNTTYAVKRLKEE-ADLEWTVV--KQSFLTEVEQLSRFRH--PNIVDFA 276

  Fly   312 KMCSLRTSKTNSTNGFVSIQKVSLVKGRYPPHFIKLWEKYDNEKGSENDHPELFGDNQLFAVLEL 376
            ..|        :.:||     ..||.|..|             .||..|.            |.|
  Rat   277 GYC--------AESGF-----YCLVYGFLP-------------NGSLEDQ------------LHL 303

  Fly   377 KFAGSDMANFKFLNSEQSYYALQQIILALAVGEEEYQFEHRD----LHLGNILIEYTNKKHIVCT 437
            :....         |..|:.....|:|..|   ...||.|:|    :| |:|
  Rat   304 QTQAC---------SPLSWPQRLDILLGTA---RAIQFLHQDSPSLIH-GDI------------- 342

  Fly   438 FKSSNLTLLSKGVNVTIIDYTLSR 461
             ||||: ||.:.:...:.|:.|:|
  Rat   343 -KSSNV-LLDERLMPKLGDFGLAR 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Haspin	NP_001015349.2	PKc_like	252..>426	CDD:304357	41/182 (23%)
Haspin	NP_001015349.2	DUF3635	479..>545	CDD:289128
Irak1	XP_006229660.1	Death_IRAK1	17..100	CDD:260061	1/8 (13%)
		PKc_like	219..522	CDD:304357	50/217 (23%)
		STYKc	219..519	CDD:214568	50/217 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346688
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930