DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Haspin and Irak2

DIOPT Version :9

Sequence 1:	NP_001015349.2	Gene:	Haspin / 3355064	FlyBaseID:	FBgn0046706	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001020593.1	Gene:	Irak2 / 362418	RGDID:	1309584	Length:	624	Species:	Rattus norvegicus

Alignment Length:	405	Identity:	85/405 - (20%)
Similarity:	139/405 - (34%)	Gaps:	133/405 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 KEPNHKNEPLTLEDCSIKV---------YCPSDSISTPCDKRLGGTTG--LF--ETDLSPITRLK 111
            :.|..::.|     ||:|.         ||   |.|.|..::|....|  ||  |.|:
  Rat   154 QRPCEEDAP-----CSLKTDVPDSLQSKYC---STSIPKQEKLLNLPGDRLFWSEADI------- 203

  Fly   112 LEGVE--DSRDKCADTNEADLY----VNVEILFQNI----NSSPKKCSNFGKKRLSNLNKMVTAV 166
            ::..|  |...:.::...||:|    ..|...|:.:    .|||.....|.:   :.:...:...
  Rat   204 VQATEDFDQSHRISEGTFADIYRGQRNGVAFAFKRLREVTGSSPGSMDRFLQ---AEMQLCLRCC 265

  Fly   167 HPSI----SLNPGKWRKSL------NNFIRSKITETNFTKKVE--RRSSICQDRKSLVLKGEHK- 218
            ||:|    ....|:...||      |..::.::.....:..:.  :|:|||   ..|:|..||.
  Rat   266 HPNILPLLGFCTGRQFHSLIYPYMANGSLQDRLWAQGDSDMLSWPQRASIC---SGLLLAVEHLH 327

  Fly   219 -----FENKYEEDVL-------KYCHQCT-PLPFN----------------TAYEQHKLLN---- 250
                 ..|....:||       |..|... |.|.|                .||.....:.
  Rat   328 SLDIIHSNVKSANVLLDQHLNPKLAHPVAHPCPTNKKTKYTVMKTHLFQASAAYLPENFIRVGQL 392

  Fly   251 TKKIGEGAYGEVFRCS-RNQEVL-------KD----HISDIVLKIIPLE-----------GSTVI 292
            ||::      ::|.|. ...|||       ||    ::.|::|..||..           |..|:
  Rat   393 TKQV------DIFSCGIVLAEVLTGIPAMDKDRSPVYLKDLLLSEIPSNTSSVHSRKTSMGKVVV 451

  Fly   293 NGEKQKTFSQ---ILPEII----ITKKMCSLRTSKTNSTNGFVSIQKV-SLVKGRYPPHFIKL-W 348
            ....||...:   :|||..    .|.....||..:.:.....||:..| ..::|:     :.| |
  Rat   452 KEICQKHLERKAGLLPEACAETWATAVSVCLRRREASLEEARVSMAGVEEQLRGQ-----LSLPW 511

  Fly   349 EKYDNEKGSENDHPE 363
            .:...:.||.::.||
  Rat   512 SRVSEDTGSSSNTPE 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Haspin	NP_001015349.2	PKc_like	252..>426	CDD:304357	32/144 (22%)
Haspin	NP_001015349.2	DUF3635	479..>545	CDD:289128
Irak2	NP_001020593.1	Death_IRAK2	3..91	CDD:176773
		PKc_like	216..504	CDD:419665	60/299 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..536		6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..593
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346689
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930