DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Haspin and Irak3

DIOPT Version :9

Sequence 1:	NP_001015349.2	Gene:	Haspin / 3355064	FlyBaseID:	FBgn0046706	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001101571.1	Gene:	Irak3 / 314870	RGDID:	1308846	Length:	610	Species:	Rattus norvegicus

Alignment Length:	520	Identity:	96/520 - (18%)
Similarity:	172/520 - (33%)	Gaps:	151/520 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 PCDKRLGGTTG----LFETDLSPITRLKLEGVEDSRD--------------KCADTNEADLYVNV 134
            ||..|  ||..    ||  ||.|....:|..:.||.|              ...|....:.||:.
  Rat     4 PCGAR--GTLSPHSLLF--DLPPALLGELCTILDSCDGPLGWRGLAERLSNSWLDVRHIEKYVHQ 64

  Fly   135 ------EILFQNINSSPKKCSNFGKKRLSNLNKM--VTAVHPSISLNPG-KWRKSLNNFIRSKIT 190
                  |:|:    |..:|....| ..|..|::|  ..|:|  :.:|.| .|...:...     .
  Rat    65 GKSGTRELLW----SWAQKNKTIG-DLLQVLHEMGHQRAIH--LIMNYGVNWTPPVQTH-----H 117

  Fly   191 ETNFTKKVERRSSICQDRKSLVLKGEHKFENKYEEDVLKYCH-------QCTPLPFNTAYEQHKL 248
            |..|.........:|::..    .|..:..|...::||...|       ..||:.|.:..|..|.
  Rat   118 ELRFPNLPPNSKPVCRESD----PGPLELANVTVDNVLVPEHNERGVVLHKTPISFQSILEGTKH 178

  Fly   249 LNTK-KIGEGAYGEVFRCS-RNQEVLKDHISDIVLKIIPLEGSTVINGEKQKTFSQILPEIIIT- 310
            .:.. .||||...||:|.. |||        ...:|:...|.:..:....::..|::  |:::.
  Rat   179 FHKDFLIGEGEIFEVYRVEIRNQ--------TYAVKLFKQEKTMQLKKHWKRFLSEL--EVLLLF 233

  Fly   311 --KKMCSLRTSKTNSTNGFVSIQKVSLVKGRYPPHFIKLWEKYDNEKGSENDHPELFGDNQLFAV 373
              ..:..|...       |..::|:.||   ||                      ...:..||..
  Rat   234 NHPHILELAAY-------FTEMEKLCLV---YP----------------------YMSNGTLFDR 266

  Fly   374 LELKFAGSDMANFKFLNSEQSYYALQQIILALAVGEEEYQFEHRDLHLGNILIEYTNKKHIVCTF 438
            |:.....:.:          |::....:::.:|   :..|..|.           |....::|..
  Rat   267 LQCTNGTTPL----------SWHVRISVLIGIA---KAIQCLHN-----------TRPCAVICGN 307

  Fly   439 KSSNLTLLSKGVNVTIIDYTLSRVTINDCCYFN-DLSRDEELFQATGDYQYDVYRMMRNELKNNW 502
            .||        .|:.:.|....::|.....:|. .|.:.......||..:..::.|....::.
  Rat   308 ISS--------ANILLDDQFQPKLTDFAAAHFRPHLEQQSSTINMTGSGRKHLWYMPEEYIRQ-- 362

  Fly   503 SSFSPKTNIIWLSYVIVKVLDSVKYKSINTKVHRMYIDKIK--ELKNIIMTF---ESASHCANYL 562
            ...:.||::.....||::||...|          :.:|..|  :|::::|..   .....|.::|
  Rat   363 GRLTIKTDVYSFGIVIMEVLTGCK----------VVLDDPKHVQLRDLLMELVEKRGLDSCLSFL 417

Fly 563 562
Rat 418 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Haspin	NP_001015349.2	PKc_like	252..>426	CDD:304357	28/178 (16%)
Haspin	NP_001015349.2	DUF3635	479..>545	CDD:289128	12/67 (18%)
Irak3	NP_001101571.1	Death_IRAK-M	15..102	CDD:260062	22/95 (23%)
		Pkinase	179..455	CDD:278497	53/325 (16%)
		PK_IRAK3	185..460	CDD:271062	53/319 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346690
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930