Protein Alignment Haspin and Irak3

DIOPT Version :10

• Sequence 1: NP_001015349.2
• Gene: Haspin / 3355064
• FlyBaseID: FBgn0046706
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_001101571.1
• Gene: Irak3 / 314870
• RGDID: 1308846
• Length: 610
• Species: Rattus norvegicus
• Alignment Length: 520
• Identity: 96/520 - (18%)
• Similarity: 172/520 - (33%)
• Gaps: 151/520 - (29%)

  Fly    88 PCDKRLGGTTG----LFETDLSPITRLKLEGVEDSRD--------------KCADTNEADLYVNV 134
            ||..|  ||..    ||  ||.|....:|..:.||.|              ...|....:.||:.
  Rat     4 PCGAR--GTLSPHSLLF--DLPPALLGELCTILDSCDGPLGWRGLAERLSNSWLDVRHIEKYVHQ 64

  Fly   135 ------EILFQNINSSPKKCSNFGKKRLSNLNKM--VTAVHPSISLNPG-KWRKSLNNFIRSKIT 190
                  |:|:    |..:|....| ..|..|::|  ..|:|  :.:|.| .|...:...     .
  Rat    65 GKSGTRELLW----SWAQKNKTIG-DLLQVLHEMGHQRAIH--LIMNYGVNWTPPVQTH-----H 117

  Fly   191 ETNFTKKVERRSSICQDRKSLVLKGEHKFENKYEEDVLKYCH-------QCTPLPFNTAYEQHKL 248
            |..|.........:|::..    .|..:..|...::||...|       ..||:.|.:..|..|.
  Rat   118 ELRFPNLPPNSKPVCRESD----PGPLELANVTVDNVLVPEHNERGVVLHKTPISFQSILEGTKH 178

  Fly   249 LNTK-KIGEGAYGEVFRCS-RNQEVLKDHISDIVLKIIPLEGSTVINGEKQKTFSQILPEIIIT- 310
            .:.. .||||...||:|.. |||        ...:|:...|.:..:....::..|::  |:::.
  Rat   179 FHKDFLIGEGEIFEVYRVEIRNQ--------TYAVKLFKQEKTMQLKKHWKRFLSEL--EVLLLF 233

  Fly   311 --KKMCSLRTSKTNSTNGFVSIQKVSLVKGRYPPHFIKLWEKYDNEKGSENDHPELFGDNQLFAV 373
              ..:..|...       |..::|:.||   ||                      ...:..||..
  Rat   234 NHPHILELAAY-------FTEMEKLCLV---YP----------------------YMSNGTLFDR 266

  Fly   374 LELKFAGSDMANFKFLNSEQSYYALQQIILALAVGEEEYQFEHRDLHLGNILIEYTNKKHIVCTF 438
            |:.....:.:          |::....:::.:|   :..|..|.           |....::|..
  Rat   267 LQCTNGTTPL----------SWHVRISVLIGIA---KAIQCLHN-----------TRPCAVICGN 307

  Fly   439 KSSNLTLLSKGVNVTIIDYTLSRVTINDCCYFN-DLSRDEELFQATGDYQYDVYRMMRNELKNNW 502
            .||        .|:.:.|....::|.....:|. .|.:.......||..:..::.|....::.
  Rat   308 ISS--------ANILLDDQFQPKLTDFAAAHFRPHLEQQSSTINMTGSGRKHLWYMPEEYIRQ-- 362

  Fly   503 SSFSPKTNIIWLSYVIVKVLDSVKYKSINTKVHRMYIDKIK--ELKNIIMTF---ESASHCANYL 562
            ...:.||::.....||::||...|          :.:|..|  :|::::|..   .....|.::|
  Rat   363 GRLTIKTDVYSFGIVIMEVLTGCK----------VVLDDPKHVQLRDLLMELVEKRGLDSCLSFL 417

  Fly   563  562
              Rat   418  417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Haspin	NP_001015349.2	Protein Kinases, catalytic domain	225..547	CDD:473864	58/336 (17%)
Irak3	NP_001101571.1	Death_IRAK-M	15..102	CDD:260062	22/95 (23%)
		PK_IRAK3	185..460	CDD:271062	53/319 (17%)