DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Haspin and H12I13.1

DIOPT Version :9

Sequence 1:	NP_001015349.2	Gene:	Haspin / 3355064	FlyBaseID:	FBgn0046706	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001335513.1	Gene:	H12I13.1 / 186732	WormBaseID:	WBGene00019190	Length:	910	Species:	Caenorhabditis elegans

Alignment Length:	530	Identity:	109/530 - (20%)
Similarity:	190/530 - (35%)	Gaps:	159/530 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 NHKNEPLTLEDCSIKVYCPSDSISTPCDKR-----------LGGTTGLFETDLSPITRLKLEGVE 116
            |.|.....|..|...::..|:::..|..:.           ..||.......|.|:....:...|
Worm   466 NRKTPGCYLNQCIKFLHTKSENVGKPFVRTTFYANFKNVVYYKGTATTLGRGLQPLLHDAIISSE 530

  Fly   117 --DSRDKC--------ADTNEADLY--------------VNVEIL-FQNINSSPKKCSNFGKKRL 156
              |.| ||        ..||::.||              ..:|:. :|:     ||.|  |..:.
Worm   531 YKDFR-KCQMLFVMSIQITNQSFLYRLAKNSFSITLDRFYRIEVCEYQS-----KKFS--GVHKC 587

  Fly   157 SNLNKMVTAVHPSISLNPGKWRKSLNNFI------RSKITETNFTKKVERRSSICQDRKSLVLKG 215
            ..|.|.: |:.|:..|..|:      |.:      |.|:...|     :..:.:|:...|...|.
Worm   588 PGLVKEI-AIKPTSDLQTGQ------NLVAHPMSSRRKMIRDN-----KSSNKVCRTSLSGGAKK 640

  Fly   216 EHKFENKYEE---DVLKYCHQCTPLPFNTAYEQHKLLNTKKIGEGAYGEVFRCSRNQEVLKDHIS 277
            :.|..|...|   .:|......|.    |::.:..:...:|||.||||..:.       :|....
Worm   641 KRKERNARSEVGDKILGITETKTV----TSWNESGIELQRKIGFGAYGSAYS-------VKYGGK 694

  Fly   278 DIVLKIIPLEGSTVINGEKQKTFSQILPEIIITKKMCSLRTSKTNSTNGFVSIQKVSLVKGRYPP 342
            .:|:|:|.      |...:|..|:    |:|||:                   |...|.|.|..|
Worm   695 TVVMKLIG------IRDNEQLLFN----ELIITQ-------------------QLGKLAKNRVCP 730

  Fly   343 HFIKLWEKY---DNEKGSENDHPELFGDNQLFAVLELKFAGSDMANFKFLNSEQSYYALQQIILA 404
            :|::....:   |...|...|...:    :..|:|..: .|..:.|:||.:..|......|::::
Worm   731 NFLEYCGSHVMTDVPVGMRRDPKAI----RHLAILMAR-GGGVLDNWKFKDYRQCVSVFCQLVMS 790

  Fly   405 LAVGEEEYQFEHRDLHLGNILIEYTNKKHIVCTFKSSNLTLLSKGVNVTIIDYTL-SRVTINDCC 468
            |.|.::.....|||:||.|:|:..|                     ..|.:||:: .:|.:|
Worm   791 LKVVKDSINMVHRDIHLWNVLVSRT---------------------KTTCLDYSMDGKVKLN--- 831

  Fly   469 YFNDLSRDEELFQATGDYQYDVYRMMRNELKNNWSSFSPKTN--IIWLSYVIVKVLDSVKYKSIN 531
                              .|.|...:.:..|:.:...:.|||  :..|.||.|.::|::|.|..:
Worm   832 ------------------SYGVVMHLIDFSKSLYGGQNKKTNEDMNDLKYVAVLIVDNLKGKEED 878

  Fly   532 -TKVHRMYID 540
             .|:.:.:|:
Worm   879 KEKLRQAFIN 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Haspin	NP_001015349.2	PKc_like	252..>426	CDD:304357	43/176 (24%)
Haspin	NP_001015349.2	DUF3635	479..>545	CDD:289128	15/65 (23%)
H12I13.1	NP_001335513.1	UCH	78..369	CDD:366104
		SPK	473..589	CDD:386186	23/123 (19%)
		PKc_like	673..>854	CDD:389743	53/263 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5072
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1374355at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820