Protein Alignment eIF4B and HNRNPDL

DIOPT Version :10

• Sequence 1: NP_001015319.1
• Gene: eIF4B / 3355041
• FlyBaseID: FBgn0020660
• Length: 459
• Species: Drosophila melanogaster
• Sequence 2: NP_112740.1
• Gene: HNRNPDL / 9987
• HGNCID: 5037
• Length: 420
• Species: Homo sapiens
• Alignment Length: 186
• Identity: 40/186 - (21%)
• Similarity: 68/186 - (36%)
• Gaps: 24/186 - (12%)

  Fly    21 FLCNSDAPVGTTQVSKKIRNLDGDDSDDGSGTLPLVYQLPTAPRANRIFDDNSIPHKAPFIAYIN 85
            |:...||......:..|...|||...|               |:..:.......|.|    .::.
Human   193 FVLFKDAASVDKVLELKEHKLDGKLID---------------PKRAKALKGKEPPKK----VFVG 238

  Fly    86 NLPFDANEDDLYEFFEGINLI-SLRLPREDGENGRSRGFGYVELENREDLIHVLSLPDPSIKGRR 149
            .|..|.:|:.:.|:|.....| ::.||.:...|.| |||.::...:.|.:..:|......|...:
Human   239 GLSPDTSEEQIKEYFGAFGEIENIELPMDTKTNER-RGFCFITYTDEEPVKKLLESRYHQIGSGK 302

  Fly   150 IRIELSNEND---QQSRQKSNRRFDGFGNNGDNRDSGNWRRDSQNNGSNFGYSSNF 202
            ..|:::...:   ||.:|:...|....|..|..|..|..:..:.|.|.|..|...:
Human   303 CEIKVAQPKEVYRQQQQQQKGGRGAAAGGRGGTRGRGRGQGQNWNQGFNNYYDQGY 358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4B	NP_001015319.1	RRM_eIF4B	78..159	CDD:409836	17/81 (21%)
HNRNPDL	NP_112740.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..83
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	96..120
		RRM1_hnRPDL	149..224	CDD:410152	9/45 (20%)
		RRM2_hnRPDL	234..308	CDD:409998	18/78 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..348		8/34 (24%)
		Necessary for interaction with TNPO1. /evidence=ECO:0000269|PubMed:9524220	342..420		4/17 (24%)
		Necessary for its nuclear import and export	396..420
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	398..420