Protein Alignment eIF4B and TIF3

DIOPT Version :10

• Sequence 1: NP_001015319.1
• Gene: eIF4B / 3355041
• FlyBaseID: FBgn0020660
• Length: 459
• Species: Drosophila melanogaster
• Sequence 2: NP_015489.1
• Gene: TIF3 / 856292
• SGDID: S000006367
• Length: 436
• Species: Saccharomyces cerevisiae
• Alignment Length: 377
• Identity: 86/377 - (22%)
• Similarity: 137/377 - (36%)
• Gaps: 121/377 - (32%)

  Fly    70 DDNSIPHKAPFIAYINNLPFDANEDDLYEFFEGINLI------SLRLPREDGENGRSRGFGYVEL 128
            ::..:|...|:.|.|||:|:|...:.:..:.|. .|:      .:.||:...:..|.:|..:|.|
Yeast    91 EEYPVPDAPPYRAVINNIPWDITPEGVQAWVED-GLVKPEAVEEVVLPKNLRDPTRLKGNAFVTL 154

  Fly   129 ENREDLIHVLSLPDPSIKGRRIRIELS-------NENDQQSRQKSNRRFDGFGNNGDNRDSG--- 183
            :.|.||:.||......:..|.:.:.::       .:.|..|.:.||.:       ||.|:..
Yeast   155 KERADLVAVLKFNGTKLNERTVYVSVAAPRRGGGADVDWSSARGSNFQ-------GDGREDAPDL 212

  Fly   184 NW-----------RRDSQN--------NGSNFGYS--------------------SNFE---RSF 206
            :|           ||:.:.        .||||..|                    |||:   |..
Yeast   213 DWGAARGSNFRGPRREREEVDIDWTAARGSNFQGSSRPPRREREEVDIDWSAARGSNFQGSSRPP 277

  Fly   207 NRERKSLPDRDDVNTPGS-WRTSARP-------QSIDTS------------PTRREVEQVSEKYR 251
            .|||:. ||.|.....|| :::|:||       ..||.|            |.|||.|:......
Yeast   278 RREREE-PDIDWSAARGSNFQSSSRPPRREREEPDIDWSAARGSNFQSSSRPPRREREKEEPALD 341

  Fly   252 EGRVKIADRYSREETSKVEEERPKLNLKPRTLPLPDVK-----TIEFEKCDVDEFNLDKQGGTSS 311
            .|..:.|.....::|....::|...| |..|...|.::     .:..|..|.|| ..:||.|.:.
Yeast   342 WGAARGAQFGKPQQTKNTYKDRSLTN-KKTTDEQPKIQKSVYDVLRTEDDDEDE-EAEKQNGDAK 404

  Fly   312 LNVFGSAKPVDTAARELEIEQRLALARKQDKGRREQGLNEKLAELQVDKNDN 363
            .|      .||.|..:|:                     :|.|:|.|:..||
Yeast   405 EN------KVDAAVEKLQ---------------------DKTAQLTVEDGDN 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4B	NP_001015319.1	RRM_eIF4B	78..159	CDD:409836	21/93 (23%)
TIF3	NP_015489.1	RRM4_RBM12_like	102..179	CDD:409936	20/77 (26%)