Protein Alignment eIF4B and TIF3

DIOPT Version :9

• Sequence 1: NP_001015319.1
• Gene: eIF4B / 3355041
• FlyBaseID: FBgn0020660
• Length: 459
• Species: Drosophila melanogaster
• Sequence 2: NP_015489.1
• Gene: TIF3 / 856292
• SGDID: S000006367
• Length: 436
• Species: Saccharomyces cerevisiae
• Alignment Length: 377
• Identity: 86/377 - (22%)
• Similarity: 137/377 - (36%)
• Gaps: 121/377 - (32%)

  Fly    70 DDNSIPHKAPFIAYINNLPFDANEDDLYEFFEGINLI------SLRLPREDGENGRSRGFGYVEL 128
            ::..:|...|:.|.|||:|:|...:.:..:.|. .|:      .:.||:...:..|.:|..:|.|
Yeast    91 EEYPVPDAPPYRAVINNIPWDITPEGVQAWVED-GLVKPEAVEEVVLPKNLRDPTRLKGNAFVTL 154

  Fly   129 ENREDLIHVLSLPDPSIKGRRIRIELS-------NENDQQSRQKSNRRFDGFGNNGDNRDSG--- 183
            :.|.||:.||......:..|.:.:.::       .:.|..|.:.||.:       ||.|:..
Yeast   155 KERADLVAVLKFNGTKLNERTVYVSVAAPRRGGGADVDWSSARGSNFQ-------GDGREDAPDL 212

  Fly   184 NW-----------RRDSQN--------NGSNFGYS--------------------SNFE---RSF 206
            :|           ||:.:.        .||||..|                    |||:   |..
Yeast   213 DWGAARGSNFRGPRREREEVDIDWTAARGSNFQGSSRPPRREREEVDIDWSAARGSNFQGSSRPP 277

  Fly   207 NRERKSLPDRDDVNTPGS-WRTSARP-------QSIDTS------------PTRREVEQVSEKYR 251
            .|||:. ||.|.....|| :::|:||       ..||.|            |.|||.|:......
Yeast   278 RREREE-PDIDWSAARGSNFQSSSRPPRREREEPDIDWSAARGSNFQSSSRPPRREREKEEPALD 341

  Fly   252 EGRVKIADRYSREETSKVEEERPKLNLKPRTLPLPDVK-----TIEFEKCDVDEFNLDKQGGTSS 311
            .|..:.|.....::|....::|...| |..|...|.::     .:..|..|.|| ..:||.|.:.
Yeast   342 WGAARGAQFGKPQQTKNTYKDRSLTN-KKTTDEQPKIQKSVYDVLRTEDDDEDE-EAEKQNGDAK 404

  Fly   312 LNVFGSAKPVDTAARELEIEQRLALARKQDKGRREQGLNEKLAELQVDKNDN 363
            .|      .||.|..:|:                     :|.|:|.|:..||
Yeast   405 EN------KVDAAVEKLQ---------------------DKTAQLTVEDGDN 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4B	NP_001015319.1	RRM	<72..268	CDD:223796	63/273 (23%)
		RRM_eIF4B	79..155	CDD:240848	21/81 (26%)
TIF3	NP_015489.1	RRM4_RBM12_like	102..179	CDD:409936	20/77 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105219
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1292
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840