DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4B and Cirbp

DIOPT Version :9

Sequence 1:	NP_001015319.1	Gene:	eIF4B / 3355041	FlyBaseID:	FBgn0020660	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	XP_006241075.3	Gene:	Cirbp / 81825	RGDID:	620756	Length:	176	Species:	Rattus norvegicus

Alignment Length:	162	Identity:	46/162 - (28%)
Similarity:	75/162 - (46%)	Gaps:	32/162 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 YINNLPFDANEDDLYEFFEGINLISLRLPREDGENGRSRGFGYVELENREDLIH-VLSLPDPSIK 146
            ::..|.||.||..|.:.|.....||..:..:|.|..||||||:|..||.:|... ::::...|:.
  Rat     9 FVGGLSFDTNEQALEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDAKDAMMAMNGKSVD 73

  Fly   147 GRRIRIELSNE-NDQQSR-------------QKSNRRFDGFGNNGDNRDSGNWR----------- 186
            ||:||::.:.: :|.:||             :....|..||...|.:|..|..|
  Rat    74 GRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRSRGRGFSRGGGDRGYGGGRFESRSGGYGGS 138

  Fly   187 RD---SQNNGSNFGYSS---NFERSFNRERKS 212
            ||   |::.|.::||.|   ::..|::...||
  Rat   139 RDYYASRSQGGSYGYRSSGGSYRDSYDSYGKS 170

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4B	NP_001015319.1	RRM	<72..268	CDD:223796	46/162 (28%)
eIF4B	NP_001015319.1	RRM_eIF4B	79..155	CDD:240848	26/72 (36%)
Cirbp	XP_006241075.3	RRM_CIRBP_RBM3	6..85	CDD:409883	26/75 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910