Protein Alignment eIF4B and Eif4b

DIOPT Version :10

• Sequence 1: NP_001015319.1
• Gene: eIF4B / 3355041
• FlyBaseID: FBgn0020660
• Length: 459
• Species: Drosophila melanogaster
• Sequence 2: NP_663600.2
• Gene: Eif4b / 75705
• MGIID: 95304
• Length: 611
• Species: Mus musculus
• Alignment Length: 536
• Identity: 149/536 - (27%)
• Similarity: 224/536 - (41%)
• Gaps: 134/536 - (25%)

  Fly     1 MASAGKKGKKNKGTVISLQSFLC-NSDAPVGTTQVSKKIR------NLDGD------DSDDGSGT 52
            ||::.|| |..||..|||..||. :.....|:|.|.|.:.      :|:||      .:||....
Mouse     1 MAASAKK-KNKKGKTISLTDFLAEDGGTGGGSTYVPKPVSWADETDDLEGDVSTTWHSNDDDVYR 64

  Fly    53 LPLVYQ--LPTAPRANR--IFDDNSIPHKAPFIAYINNLPFDANEDDLYEFFEGINLISLRLPRE 113
            .|.:.:  |||||||.|  ..|.:.:|...|:.|::.|||:|..||.:.:||.|:|:.::|||||
Mouse    65 APPIDRSILPTAPRAAREPNIDRSRLPKSPPYTAFLGNLPYDVTEDSIKDFFRGLNISAVRLPRE 129

  Fly   114 DGENGRSRGFGYVELENREDLIHVLSLPDPSIKGRRIRIELSNENDQQSRQKSNRRFDGFGNNGD 178
            .....|.:||||.|.|:.:.|:..|||.:.|:..||||::::::  .|.:.:.:|.|....|...
Mouse   130 PSNPDRLKGFGYAEFEDLDSLLSALSLNEESLGNRRIRVDVADQ--AQDKDRDDRSFGRDRNRDS 192

  Fly   179 NRDSGNW--------------RRDSQNNGSNF-----------GYSSNFERSFNRERKSLPDRDD 218
            ::...:|              ||...:.|..:           ||...:.....|:......||.
Mouse   193 DKTDTDWRARPTTDSFDDYPPRRGDDSFGDKYRDRYDSDRYRDGYRDGYRDGPRRDMDRYGGRDR 257

  Fly   219 VNTPGSWRTSARPQSIDTSPTRREV---EQVSEKYREGRVKIADRY---------SREETSKVE- 270
            .:..|| |...|.........||..   .:..:.||.|..:..|||         ||::.|:.:
Mouse   258 YDDRGS-RDYDRGYDSRIGSGRRAFGSGYRRDDDYRGGGDRYEDRYDRRDDRSWSSRDDYSRDDY 321

  Fly   271 -------EERPKLNLKPRTLPLPDVKTIEFEKCDVDEFNLDKQGGTS----SLNVFGSAKPVDTA 324
                   .:||:||||||:.|..|                |....||    :.::||.|||||||
Mouse   322 RRDDRGPPQRPRLNLKPRSAPKED----------------DASASTSQSSRAASIFGGAKPVDTA 370

  Fly   325 ARELEIEQRLALARKQDKGRREQGLNEKLAELQVDKNDNESLSATVSWRTNQDYKESDKINKCPG 389
            |||.|:|:|  |.::|:|      |..:|.|.::|:...|   ...|||:
Mouse   371 AREREVEER--LQKEQEK------LQRQLDEPKLDRRPRE---RHPSWRS--------------- 409

  Fly   390 EKQRDEEIHRLNHARGQ----------FNRPELLREKPNANGESKRDCRNDRSVSKKTSQ----- 439
            |:.::.|..|......|          ..|.|..:...|.....:.||.:..|...|..|
Mouse   410 EETQERERSRTGSESSQTGASATSGRNTRRRESEKSLENETLNKEEDCHSPTSKPPKPDQPLKVM 474

  Fly   440 -------NDLVLQSSN 448
                   |..|.:|||
Mouse   475 PAPPPKENAWVKRSSN 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4B	NP_001015319.1	RRM_eIF4B	78..159	CDD:409836	33/80 (41%)
Eif4b	NP_663600.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..93		32/92 (35%)
		RRM_eIF4B	94..175	CDD:409836	33/82 (40%)
		PRK12678	<158..>273	CDD:237171	22/117 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	173..611		84/363 (23%)
		PTZ00108	<372..578	CDD:240271	33/145 (23%)