DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4B and eif4ba

DIOPT Version :9

Sequence 1:	NP_001015319.1	Gene:	eIF4B / 3355041	FlyBaseID:	FBgn0020660	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	NP_001092707.2	Gene:	eif4ba / 553214	ZFINID:	ZDB-GENE-060629-1	Length:	616	Species:	Danio rerio

Alignment Length:	506	Identity:	142/506 - (28%)
Similarity:	229/506 - (45%)	Gaps:	121/506 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASAGKKGKKNKGTVISLQSFLCN--------SDAPVGTTQVSKKIRNLDGD-----DSDDGSGT 52
            ||::.||.|| ||..::|..||..        |.||...|..:.:..:|:||     .::|....
Zfish     1 MAASAKKNKK-KGKTLTLTDFLAEDSGGNAPPSYAPPKPTSWADETDDLEGDVTTSWHTEDEVYR 64

  Fly    53 LPLVYQ--LPTAPRANR--IFDDNSIPHKAPFIAYINNLPFDANEDDLYEFFEGINLISLRLPRE 113
            .|.:.:  |||||||.|  ..|.:.:|...|:.|::.|||:|..||.:..||.|:::.::|||||
Zfish    65 APPIDRSILPTAPRAAREPNVDRSRLPRSPPYTAFLGNLPYDVTEDSIKNFFRGLSISAVRLPRE 129

  Fly   114 DGENGRSRGFGYVELENREDLIHVLSLPDPSIKGRRIRIELSNENDQQSRQKSNRRFDGFGNNGD 178
            .....|.:||||.|.::.|.|:..|||.:.::..||||:::::::::  :::.:|...|...|..
Zfish   130 PSNPERLKGFGYAEFDDVESLLQALSLNEENLGNRRIRVDIADQSNE--KERDDRSVSGRDRNRS 192

  Fly   179 NRDSG------NWR------------------------------RDSQ---NNGSNFGYSSNFER 204
            :||.|      :||                              |:.|   |:..:.|.....||
Zfish   193 DRDMGPDKTDSDWRARPKSEADDGPRRDDAFAERSKDRYDSDRHREGQRWDNDRYDGGRDRYRER 257

  Fly   205 SFNRERKSLPDRDDVNTPGSWRTSARPQSIDTSPTRREVEQVSEKYREGRVKIADRY-SREETSK 268
            ..:|||:......|..:.|     .||..   |..||:.:...:.:|..    .||| .|||..:
Zfish   258 YDDRERRDYDRGFDSRSGG-----RRPFG---SGFRRDYDDRRDDFRGS----GDRYGDREERFE 310

  Fly   269 VEEE---------RPKLNLKPRTLPLPDVKTIEFEKCDVDEFNLDKQGGTSS----LNVFGSAKP 320
            ..:|         |||||||||::|..:..:               :|.::|    .::||.|||
Zfish   311 RRDERRDDRGPPQRPKLNLKPRSVPKDEEPS---------------RGPSASSGRAASIFGGAKP 360

  Fly   321 VDTAARELEIEQRLALARKQDKGRREQGLNEKLAELQVDKN---DNESLSATVSWRT-------N 375
            |||||:|.|:|:|  |.::||:.:|         :|:.|||   :.:......|||:       :
Zfish   361 VDTAAKEREVEER--LKKEQDRLQR---------QLEEDKNRGPERKPRERHPSWRSEDQGTERS 414

  Fly   376 QDYKESDKINKCPGEKQRDEEIHRLNHARGQFNRPELLREKPNANGESKRD 426
            :...||.:....|...||..|..|........:|.|.|....:.:..||::
Zfish   415 RTGSESSQTGNPPSRGQRRRESERSVENEVFSSRDEELSSHGSQSPASKQE 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4B	NP_001015319.1	RRM	<72..268	CDD:223796	63/235 (27%)
eIF4B	NP_001015319.1	RRM_eIF4B	79..155	CDD:240848	31/75 (41%)
eif4ba	NP_001092707.2	RRM	<91..235	CDD:223796	40/145 (28%)
eif4ba	NP_001092707.2	RRM_eIF4B	95..171	CDD:240848	31/75 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595132
Domainoid	1	1.000	68	1.000	Domainoid score	I9709
eggNOG	1	0.900	-	-		E33208_3BDSB
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	148	1.000	Inparanoid score	I4369
OMA	1	1.010	-	-		QHG58965
OrthoDB	1	1.010	-	-		D1530583at2759
OrthoFinder	1	1.000	-	-		FOG0007285
OrthoInspector	1	1.000	-	-		otm26060
orthoMCL	1	0.900	-	-		OOG6_105219
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1292
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.740