Protein Alignment eIF4B and eif4b

DIOPT Version :9

• Sequence 1: NP_001015319.1
• Gene: eIF4B / 3355041
• FlyBaseID: FBgn0020660
• Length: 459
• Species: Drosophila melanogaster
• Sequence 2: XP_012812217.1
• Gene: eif4b / 448618
• XenbaseID: XB-GENE-988676
• Length: 614
• Species: Xenopus tropicalis
• Alignment Length: 636
• Identity: 159/636 - (25%)
• Similarity: 258/636 - (40%)
• Gaps: 206/636 - (32%)

  Fly     1 MASAGKKGKKNKGTVISLQSFLCNSDAP---------------VGTTQVSKKIR------NLDGD 44
            ||::.|| |..||..::|..||.:....               .|:|...|.:.      :|:||
 Frog     1 MAASAKK-KNKKGKTLTLTDFLADDGGSGGGGGGGGSGGGGGGGGSTYAPKPVNWADETDDLEGD 64

  Fly    45 ------DSDDGSGTLPLVYQ--LPTAPRANR--IFDDNSIPHKAPFIAYINNLPFDANEDDLYEF 99
                  .:||.:...|.:.:  |||||||.|  ..|.:.:|...||.|::.|||:|..|:.:.:|
 Frog    65 VSTTWHSNDDDAYRAPPIDRSILPTAPRAAREPNVDRSRLPKSPPFTAFLGNLPYDVTEESIQKF 129

  Fly   100 FEGINLISLRLPREDGENGRSRGFGYVELENREDLIHVLSLPDPSIKGRRIRIELSNENDQQSRQ 164
            |.|:|:.::|||||.....|.:||||.|.::.:.|:..|||.:.|:..||||::::::...:.|.
 Frog   130 FRGLNISAVRLPREPSNPERLKGFGYAEFDDLDSLLRALSLNEESLGNRRIRVDIADQAQDKDRD 194

  Fly   165 KSNRRFDGFGNNGD-NR-----DSGNW--------------RRDSQNNGSNF---GYSSN----- 201
            :.:     ||.:.| ||     ||.:|              ||...:.|..:   .|.|:
 Frog   195 ERS-----FGRDRDRNRESDKTDSSDWRARPSTDSFDDYPPRRGDDSQGDRYRSDRYESDRYRDG 254

  Fly   202 -------FERSFNRERKSLPDRDDVNTPGSWRTSARPQSIDTSPTRRE---------VEQVSEKY 250
                   :||...|:|....:|.|.:.....|...|...   |..||:         .::..::|
 Frog   255 PRRDGDRYERDRGRDRYDDRNRSDYDRGYDSRGGRRAFG---SGYRRDDDYRGGGGGGDRYGDRY 316

  Fly   251 REGRVKIADR---YSREETSKVEE----ERPKLNLKPRTLPLPDVKTIEFEKCDVDEFNLDKQGG 308
            .|.|...:||   |||.|..:.|.    :||||||||||.|                  .|::||
 Frog   317 EERREDRSDRWNGYSRNEERREERAGPTQRPKLNLKPRTAP------------------KDEEGG 363

  Fly   309 TS-----SLNVFGSAKPVDTAARELEIEQRLALARKQDKGRREQGLNEKLAELQ----------- 357
            .|     :.::||.||||||||||.|:|:|  |.::|:|.::.|..:::..:::
 Frog   364 PSAATSRAASIFGGAKPVDTAAREREVEER--LQKEQEKMQQRQLEDDRPRQIERKPRERHPSWR 426

  Fly   358 VDKNDNESLSATVSWRT--------------------NQDY-KESD-----------------KI 384
            .|:|...|.:.:.|.:|                    |:.: |:.|                 |:
 Frog   427 SDENQERSRTGSESSQTATGGSSSRISRRRESEKSVENEVFGKDEDAPSPSSKSPKSDSQLPLKV 491

  Fly   385 NKCPGEKQ---------------------RDEEIH-------RLNHARGQFNRPELLREKPNANG 421
            ...|..|:                     :..|:|       ..:|.|...|:.:.|.....:.|
 Frog   492 MPAPPPKENAWVKRSTAAPSSRSHSSEYSQSGEMHPDERRQPGTSHPRVDENKVDALEHLAKSGG 556

  Fly   422 ------------ESKRDCRND-RSVSKKTSQNDLVLQSSNKYSGLDNEGSE 459
                        :.|||..:. ...|||..:..:....::||:.|..:|.|
 Frog   557 HGVGDRNRAPDKKEKRDLDSQGMPESKKMDEQAVKFSHASKYAALSMDGEE 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4B	NP_001015319.1	RRM	<72..268	CDD:223796	67/242 (28%)
		RRM_eIF4B	79..155	CDD:240848	32/75 (43%)
eif4b	XP_012812217.1	RRM_eIF4B	109..185	CDD:240848	32/75 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9511
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	149	1.000	Inparanoid score	I4281
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1530583at2759
OrthoFinder	1	1.000	-	-		FOG0007285
OrthoInspector	1	1.000	-	-		oto105251
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1292
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.090