DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4B and eif4bb

DIOPT Version :9

Sequence 1:	NP_001015319.1	Gene:	eIF4B / 3355041	FlyBaseID:	FBgn0020660	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	XP_005166071.1	Gene:	eif4bb / 336619	ZFINID:	ZDB-GENE-030131-8563	Length:	632	Species:	Danio rerio

Alignment Length:	505	Identity:	143/505 - (28%)
Similarity:	226/505 - (44%)	Gaps:	141/505 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASAGKKGKKNKGTVISLQSFLCN---SDAPVG--TTQVSKKIRNLDGDDSDDGSG-------TL 53
            ||::.||.|| ||..::|..||.:   .:||..  ||:.:..     .|::||..|       |:
Zfish     1 MAASAKKNKK-KGKTLTLNDFLADETGGNAPPSFPTTKATSW-----ADETDDLEGDVSTSWHTV 59

  Fly    54 PLVYQ--------LPTAPRANR--IFDDNSIPHKAPFIAYINNLPFDANEDDLYEFFEGINLISL 108
            ...|:        |||||||.|  ..|.:.:|...|:.|::.|||:|.:|:.:.:||.|:.:.::
Zfish    60 EDTYRAPPIDRSILPTAPRAAREPNVDRSRLPRSPPYTAFLGNLPYDVSEESIRDFFRGLAISAV 124

  Fly   109 RLPREDGENGRSRGFGYVELENREDLIHVLSLPDPSIKGRRIRIEL---SNENDQQSRQKSNRRF 170
            |||||.....|.:||||.|.::.|.|:..|||.:.::..||||:::   ||:.::.|...|.|..
Zfish   125 RLPREPNNPERLKGFGYAEFDDIESLLRALSLNEENLGNRRIRVDIADQSNDKERDSGMMSGRDR 189

  Fly   171 D---GFG-NNGDNRDSGNWR---RDSQNNG--SNFGYSSNFERSFNRER-KSLPDRDDVNTPGSW 225
            |   |.| ::|.::...:||   ...|::|  .:.||.......:..:| :..|.|||
Zfish   190 DRDRGRGMDSGPDKTDSDWRARPSSDQDDGPRKDDGYGDKSRDRYESDRFRDGPRRDD------- 247

  Fly   226 RTSARPQSID---------------------------------------TSPTRREVEQVSEKYR 251
            |.|.|.:..|                                       :|..||:.|.    .|
Zfish   248 RFSGRDRYDDRDRKDRYDDRDRRDRFDDRGSRDYDRGGFDSRGGGRRGFSSGFRRDYED----RR 308

  Fly   252 EGRVKIADRYSREETSKVEE---ERPKLNLKPRTLPLPDVKTIEFEKCDVDEFNLDKQGGTS--- 310
            :|. :..||..|.:..:.|.   :|||||||||::|..:                ::.|..|
Zfish   309 DGD-RFGDREDRRDEGREERGPPQRPKLNLKPRSIPKEE----------------EQSGSVSPQS 356

  Fly   311 -------SLNVFGSAKPVDTAARELEIEQRLALARKQDKGRREQGLNEKLAELQVDKN---DNES 365
                   :.::||:||||||||:|.|:|:||    |:::.|.::.|.|       |||   :...
Zfish   357 NPTNTSRASSIFGAAKPVDTAAKEREVEERL----KKEQERLQRQLEE-------DKNRPSERRP 410

  Fly   366 LSATVSWRTNQDYKE----SDKINKCPGEKQRDEEIHRLNHA-RGQFNRP 410
            .....|||:.:..||    ..:.:...|.:.||:| |..|.. .||.:.|
Zfish   411 RDRDPSWRSEEPPKERQHTGSESSHPKGSRCRDDE-HSENEVFSGQESEP 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4B	NP_001015319.1	RRM	<72..268	CDD:223796	64/247 (26%)
eIF4B	NP_001015319.1	RRM_eIF4B	79..155	CDD:240848	30/78 (38%)
eif4bb	XP_005166071.1	RRM	<91..246	CDD:223796	48/154 (31%)
eif4bb	XP_005166071.1	RRM_eIF4B	95..171	CDD:240848	30/75 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595131
Domainoid	1	1.000	68	1.000	Domainoid score	I9709
eggNOG	1	0.900	-	-		E33208_3BDSB
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	148	1.000	Inparanoid score	I4369
OMA	1	1.010	-	-		QHG58965
OrthoDB	1	1.010	-	-		D1530583at2759
OrthoFinder	1	1.000	-	-		FOG0007285
OrthoInspector	1	1.000	-	-		otm26060
orthoMCL	1	0.900	-	-		OOG6_105219
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1292
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.790