DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment eIF4B and EIF4B

DIOPT Version :9

Sequence 1:NP_001015319.1 Gene:eIF4B / 3355041 FlyBaseID:FBgn0020660 Length:459 Species:Drosophila melanogaster
Sequence 2:NP_001287750.1 Gene:EIF4B / 1975 HGNCID:3285 Length:616 Species:Homo sapiens


Alignment Length:635 Identity:162/635 - (25%)
Similarity:252/635 - (39%) Gaps:198/635 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MASAGKKGKKNKGTVISLQSFLC-NSDAPVGTTQVSKKIR------NLDGD------DSDDGSGT 52
            ||::.|| |..||..|||..||. :.....|:|.|||.:.      :|:||      .:||....
Human     1 MAASAKK-KNKKGKTISLTDFLAEDGGTGGGSTYVSKPVSWADETDDLEGDVSTTWHSNDDDVYR 64

  Fly    53 LPLVYQ--LPTAPRANR--IFDDNSIPHKAPFIAYINNLPFDANEDDLYEFFEGINLISLRLPRE 113
            .|.:.:  |||||||.|  ..|.:.:|...|:.|::.|||:|..|:.:.|||.|:|:.::|||||
Human    65 APPIDRSILPTAPRAAREPNIDRSRLPKSPPYTAFLGNLPYDVTEESIKEFFRGLNISAVRLPRE 129

  Fly   114 DGENGRSRGFGYVELENREDLIHVLSLPDPSIKGRRIRIELSNENDQQSRQKSNRRFDGFGNNGD 178
            .....|.:||||.|.|:.:.|:..|||.:.|:..||||::::::  .|.:.:.:|.|....|...
Human   130 PSNPERLKGFGYAEFEDLDSLLSALSLNEESLGNRRIRVDVADQ--AQDKDRDDRSFGRDRNRDS 192

  Fly   179 NRDSGNW--------------RRDSQNNGSNF-----------GYSSNFERSFNRERKSLPDRDD 218
            ::...:|              ||...:.|..:           ||...:.....|:......||.
Human   193 DKTDTDWRARPATDSFDDYPPRRGDDSFGDKYRDRYDSDRYRDGYRDGYRDGPRRDMDRYGGRDR 257

  Fly   219 VNTPGSWRTSARPQSIDTSPTRREV---EQVSEKYREGRVKIADRY---------SREETSKVE- 270
            .:..|| |...|.........||..   .:..:.||.|..:..|||         ||::.|:.: 
Human   258 YDDRGS-RDYDRGYDSRIGSGRRAFGSGYRRDDDYRGGGDRYEDRYDRRDDRSWSSRDDYSRDDY 321

  Fly   271 -------EERPKLNLKPRTLPLPDVKTIEFEKCDVDEFNLDKQGGTS----SLNVFGSAKPVDTA 324
                   .:|||||||||:.|..|                |....||    :.::||.|||||||
Human   322 RRDDRGPPQRPKLNLKPRSTPKED----------------DSSASTSQSTRAASIFGGAKPVDTA 370

  Fly   325 ARELEIEQRL-----ALARKQDKGRREQ--------GLNEKLAELQVDKNDNESL---SATVSWR 373
            |||.|:|:||     .|.|:.|:.:.|:        ..:|:..|.:..:..:||.   ::|.|.|
Human   371 AREREVEERLQKEQEKLQRQLDEPKLERRPRERHPSWRSEETQERERSRTGSESSQTGTSTTSSR 435

  Fly   374 TNQDY----KESDK------INK---C-------------------------------------- 387
            :..|.    :||:|      :||   |                                      
Human   436 SKSDQDARRRESEKSLENETLNKEEDCHSPTSKPPKPDQPLKVMPAPPPKENAWVKRSSNPPARS 500

  Fly   388 --------------------------PGEKQRDEEIHRLNHARGQF-----------NRPELLRE 415
                                      ||.|. :.::..:|..:||.           || :..:|
Human   501 QSSDTEQQSPTSGGGKVAPAQPSEEGPGRKD-ENKVDGMNAPKGQTGNSSRGPGDGGNR-DHWKE 563

  Fly   416 KPNANGESKRDCRNDRSVSKKTSQNDLVLQSSNKYSGL------DNEGSE 459
            ....:|:..:|.|:.....|..........|::||:.|      :|||.:
Human   564 SDRKDGKKDQDSRSAPEPKKPEENPASKFSSASKYAALSVDGEDENEGED 613

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eIF4BNP_001015319.1 RRM <72..268 CDD:223796 61/232 (26%)
RRM_eIF4B 79..155 CDD:240848 33/75 (44%)
EIF4BNP_001287750.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37 16/36 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 66..93 11/26 (42%)
RRM <83..>190 CDD:223796 38/108 (35%)
RRM_eIF4B 95..171 CDD:240848 33/75 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159079
Domainoid 1 1.000 71 1.000 Domainoid score I9537
eggNOG 1 0.900 - - E33208_3BDSB
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 154 1.000 Inparanoid score I4326
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG58965
OrthoDB 1 1.010 - - D1530583at2759
OrthoFinder 1 1.000 - - FOG0007285
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_105219
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1292
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.700

Return to query results.
Submit another query.