DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(3)80Fj and GCN1

DIOPT Version :10

Sequence 1:NP_001015316.1 Gene:l(3)80Fj / 3355040 FlyBaseID:FBgn0287182 Length:2630 Species:Drosophila melanogaster
Sequence 2:NP_011320.3 Gene:GCN1 / 852680 SGDID:S000003163 Length:2672 Species:Saccharomyces cerevisiae


Alignment Length:2783 Identity:820/2783 - (29%)
Similarity:1363/2783 - (48%) Gaps:416/2783 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 VEERQHLFQNVSSVLKNSGINSTIIRGICKVIGTTITKYKDPTSQRIVRDLIVDLVTIHHDLTIE 86
            |.:|....|::|.:::...:....:..|..|:..|.|.|:|..|:.:|..:::|::.:...|   
Yeast    23 VSKRVPFLQDISQLVRQETLEKPQLSEIAFVLLNTFTIYEDNRSKSLVTSILLDILNLEPCL--- 84

  Fly    87 HMLNVFKAFIYKEFASVSPQKSCKLAVIALGWISIIQKQAQRESNIFKTEKKKLI---EYQTLLY 148
              |..|..||.....|....|:....:..|.||:.........||:|:....||:   .|.|  :
Yeast    85 --LENFIRFISDVVISNPATKAVADYLNLLDWINSFLIFVSHNSNLFEEYIPKLLVAHSYAT--F 145

  Fly   149 QITVISPNQ--------RVTDARTKILYDLWNNT-----EIFNETMDTLFQM--------ESTSN 192
            .:..|..||        :....|.:|.|.::..|     :...:..|::..|        ||.|.
Yeast   146 GVETILDNQEEGKKSQDKQNQHRKRIRYCIFQTTVKAFLKCLKDNDDSISFMKISIKTVLESYSK 210

  Fly   193 VTI-----------FCMAMFQFKYKN---CNALKLNQYTEKLSEYFVKSMISCKHKPDKSFI--I 241
            :.|           ...|..|...:.   .:.||.|. .||..||..|.:...|: |..||.  |
Yeast   211 LKITSVGVVMIMGALTQAALQLLSRQPALHSVLKENS-AEKYCEYLGKEVFLGKN-PPSSFCLEI 273

  Fly   242 ACSPLLKSLTDAE-FDSYIYPSLQRSILRSPENTLQSIGLIF--------NMLN-FDCSRYAQKV 296
            ...|.||.....| |..:..|::::::|||||.....:..::        |:|| |..|:...: 
Yeast   274 GLKPFLKEFVSQELFIKFFIPNIEKAVLRSPEVGFSILSELYAGVSPEKVNLLNAFASSKLINQ- 337

  Fly   297 GIVLIKNLYSKGDIARQESLESLKLLSTKCSN--------WIIVKELLERIFSVLNGSDGKINVI 353
               ...:..|..::.|..||:|:.:|..|.||        ..::.|:.:.|.|.|| :|.|..:.
Yeast   338 ---YFSSFKSSKEVVRSVSLQSMIILLRKISNTDTTLEDLTKLIDEIFKNIKSNLN-ADYKSLIS 398

  Fly   354 EYRINILQGAGNLSFNNIDQDHMPNILNEAVTLFSKALECETQEKVICCTLEMFGLWTQKFIHNL 418
            :..|.|     .|:...:.:.....:        |..:..|..|..:...|..|      |:|  
Yeast   399 KILIEI-----PLTHYEVSEKICKGL--------SPYIGKEGNEAALTLMLNAF------FVH-- 442

  Fly   419 PDVVINIFTSGMRLKTTNQIIRQSYLE--------WLLLSIQNAEVNNHISIIQDLISFYTKALQ 475
                  .|:.|..::..::||...:.:        |....:.|:...:.    :.:::|....|:
Yeast   443 ------YFSLGKPIEDLDKIISAGFADKKPALKKCWFAAFLNNSNAASE----EVILNFIDGCLE 497

  Fly   476 NSSQSCYLSEAACIACILLILEKPSENYNFFWTTVFDMKKLIFYNEKFTTTAPIPTLCNISLMAR 540
            ....|....:....||||..:|                    |.|:       |..|.|..|..|
Yeast   498 FVKDSIIHYQTHGHACILASIE--------------------FTNK-------ILALDNTELNDR 535

  Fly   541 I--LINSYPEKIKGKLEPLARTLVSNLCCNSVKVRVYTAKQVKQIINSSSGIEFVKLALCEFGKR 603
            :  ||.:.||........|...|.:.|   |::.|::....::::.....  ||:..::      
Yeast   536 VMQLIETLPENSSIGDAILTAALSTEL---SIENRIHAVNLLQELFYKKP--EFIGFSV------ 589

  Fly   604 INLVNIETDGEPLIDQFGTSNQVYVDALLTLTSIKHITYEDSVDVAIDLLLISH----------- 657
            |:.:......:.||.|..||.:.....||.:|| :....|.|:.|.|:.|:|:.           
Yeast   590 IDAIERRMRVQELIPQQNTSFKYVTSVLLAITS-ELPDKEASIKVLINALVIAQWNIFNIKNGWA 653

  Fly   658 --------HPAIVSNEPYLWETTIQKHLNLDAKNVILAKTNEIVN--EYIDN-YIASAQYENTIS 711
                    .||.|          :::|     .:||:.|..||..  |:||. |.|........:
Yeast   654 GLVLRARLDPAEV----------VKEH-----ASVIMEKILEITGSCEWIDTIYGACGLQAAAYA 703

  Fly   712 ALIRICPNLIVPTVVNNLKNYLSNFSNYNVSNEEYLIFLTPDGELFDKSVIPHIDSQYETVRLKR 776
            |.|:  ||...|.:...::..|:......:|.|::.||...:|.|.       :|...|::..|.
Yeast   704 AFIQ--PNEFTPILCKTIEADLTADDFSRLSEEDFEIFAGEEGVLV-------VDVLEESMNKKL 759

  Fly   777 ENKVYSYKEQLEEIQLRREIDDKREKEGKLKTIRYTQKQEEQIKN-QMEKELHIKLRITLLYE-- 838
            .||   ..::.|.:...::|    .||...|.::...|:|:::.| |:.||..::..::.:..  
Yeast   760 SNK---NSKEYETLMWEQKI----RKEQAKKNVKKLSKEEQELVNEQLAKESAVRSHVSEISTRL 817

  Fly   839 ----KLISKISLLKASC-SGNGEQMAQHFYSLLDGILNASKSPLCAEVLTDLYIFLHNLCFTFQP 898
                :|:|::|  ||:| ..||  :|..|...:..:|.....|..:::..|:......|......
Yeast   818 KRGIRLVSELS--KAACLVQNG--IATWFPLAVTKLLYLCSEPNISKLTEDVNNVFLQLSQNVSE 878

  Fly   899 KLGRA---IALATIKLQSPSCVLKKEFEAFNVNQ-AINDIIIDLDNHV------KSNY--LDSPS 951
            :||..   :.|||:::.:          |..::| .:.:.:::|...|      .||.  :||.|
Yeast   879 RLGNIRLFLGLATLRVHN----------ANGISQDYLQEPLVELLTRVLFRIKFVSNQAAIDSIS 933

  Fly   952 FSYAFEFL------KRALLLLNTD-----SDF-------DLISKGIQILALHTSAGVCCKPQFMP 998
            .:|....|      .:|:.|.|.|     ::|       :.:...::|:::|..|   .:...:|
Yeast   934 LTYILPLLINVLEKGKAIALKNADKPVVKAEFVEEDEEEEHLLLAMEIISVHAEA---FEDPSIP 995

  Fly   999 RFGMFKMLLDLLKNNNKLWAQTSAAILQVAK-CSNGDNCSS----PDNHIISIFLQALQHCSDAV 1058
            |..:.::||.||...:|         .::|| |.|. .|.|    |:...:.:.|..|...:..|
Yeast   996 RISIVEVLLSLLSLPSK---------AKIAKDCFNA-LCQSISVAPNQEDLDMILSNLLSPNQFV 1050

  Fly  1059 RKVALQSLKIMVNGIVNHIKVDNSLE---------KVIINRFWVAKHDPEEENRELALFLWNTAK 1114
            |...|::|             ||..|         :|.|.||     |.:..|||:|.|:|...|
Yeast  1051 RSTILETL-------------DNEFELEPFMKYSPEVFICRF-----DSDPSNREIADFIWEFNK 1097

  Fly  1115 FPLPGYVDIIND---------ITHSETCIQKSASES----LIPLLAGDEVLKKCVIKKLFSIYKA 1166
            |       ::||         ....::.::..|:.:    .:.|...:|...|..:..|.:.||.
Yeast  1098 F-------VVNDELLKSLFPLFNQDDSGLRLFAANAYAFGAVSLFTSEENSSKDYLNDLLNFYKE 1155

  Fly  1167 KLSLLPPVLDQFDREIEPAIDQ---WKPRRGIAIAFSTIAFLLSIED--INDIMNFMVSQ-GLGD 1225
            |...|.|:||||...:..|.:|   |:.|..:||....:|...|.||  :.:|:.|:|.. ||.|
Yeast  1156 KAKPLEPILDQFGLVLVSASEQKDPWQGRSTVAITLKIMAKAFSAEDDTVVNIIKFLVDDGGLVD 1220

  Fly  1226 REDVVHKEMLATALKIVDLHGNKAIENLLPVFEDFLDKAPKSQSYDN-IRQAVVILMGSLARHLE 1289
            ||.:|.:||....::::.|||::..::|:|:||:.|     |.|.|: :::.|:||.|:|||||:
Yeast  1221 REPIVRQEMKEAGVELITLHGSQNSKDLIPIFEEAL-----SSSTDSALKENVIILYGTLARHLQ 1280

  Fly  1290 KDDKRIDPIVKRLITSLSTPSQQVQEAVSNCLPHLM----PSVKDEAPSMIKKLLHSLAKSEKYG 1350
            :.|.||..|::||:::|.|||..:|:|||.|:..|:    ..|.|....:::|||:....|..  
Yeast  1281 QSDARIHTIIERLLSTLDTPSADIQQAVSACIAPLVFQFKQKVGDYLGILMEKLLNPTVASSM-- 1343

  Fly  1351 ERRGAAYGIAGIVKGLGILSLKQLDIMSKLTAFIQDKKNYRSREGALFAFEVLCSTLGRLFEPYI 1415
             |:|||:||||:|||.||.:|.:.||:..|....:|||..:.||...|.|:.|..:||:.||||:
Yeast  1344 -RKGAAWGIAGLVKGYGISALSEFDIIRNLIEAAEDKKEPKRRESVGFCFQYLSESLGKFFEPYV 1407

  Fly  1416 VHVLPHLLQCFGDPSQYVRQAADDTAKVVMRKLSAHGVKLVLPSLLEALDEDSWRTKTASVELLG 1480
            :.:||::|:..||....||.|.....|.:|...:.:|||.::|..:..|||.:||||..||:|||
Yeast  1408 IEILPNILKNLGDAVPEVRDATARATKAIMAHTTGYGVKKLIPVAVSNLDEIAWRTKRGSVQLLG 1472

  Fly  1481 AMAFCAPKQLSSCLPSIVPKLIQVLGDSHTKVQESGGEALKVIGSVIKNPEIQAIVPVLLDALED 1545
            .||:..|.|||:.|.:|||:::.||.|||.:|:::..|:||..|.||:|||||.:|||||.|:.|
Yeast  1473 NMAYLDPTQLSASLSTIVPEIVGVLNDSHKEVRKAADESLKRFGEVIRNPEIQKLVPVLLQAIGD 1537

  Fly  1546 PSNNTSTCLQSLLKTKFIHFIDAPSLALIMPVVQRAFMDRSTETRKMAAQIIGNMYSLTDQKDLA 1610
            |:..|...|.||::|:|:|:||.||||||:.::.|...|||...::.|.:|:|||..|.|.|||.
Yeast  1538 PTKYTEEALDSLIQTQFVHYIDGPSLALIIHIIHRGMHDRSANIKRKACKIVGNMAILVDTKDLI 1602

  Fly  1611 PYLPSIIPGLKSSLLDPVPEVRAVSARALGAMVKGMGESSFENLLPWLMETLTSESSSVDRSGAA 1675
            |||..:|..::.:::||||..||.:||||||:|:.:||..|.:|:|.|::||:.||.|.||.|:|
Yeast  1603 PYLQQLIDEVEIAMVDPVPNTRATAARALGALVERLGEEQFPDLIPRLLDTLSDESKSGDRLGSA 1667

  Fly  1676 QGLSEVVGGLGVEKMHKLMPEIISTAERVDIAAHVKDGYIMMFIYMPGAFQEEFTPYIGQIINPI 1740
            |.|:||:.|||:.|:.:::|.|:  |...:..|::::|::.:.:::|..|..:|.|||.|||.||
Yeast  1668 QALAEVISGLGLTKLDEMLPTIL--AGVTNFRAYIREGFMPLLLFLPVCFGSQFAPYINQIIQPI 1730

  Fly  1741 LKALADESEFVRDTALKAGQRIVNLYAETAVALLLPELEKGLFDDNWRIRYSSVQLLGDLLYRIS 1805
            |..|||..|.:||||||||:.||..||..||.|||||||:|:||:|.|||.|||||.|:||::::
Yeast  1731 LSGLADNDENIRDTALKAGKLIVKNYATKAVDLLLPELERGMFDENDRIRLSSVQLTGELLFQVT 1795

  Fly  1806 GVSGKMTTETASEDDNFGTEHSHTAIIHFLGDERRNRVLSGLYMGRSDVSLMVRQAALHVWKVVV 1870
            |:|.:  .|.:.||.:...|.| ..::..||.:||:|:|:.|::.|:|.|.:||...:.:||.:|
Yeast  1796 GISSR--NEFSEEDGDHNGEFS-GKLVDVLGQDRRDRILAALFVCRNDTSGIVRATTVDIWKALV 1857

  Fly  1871 TNTPRTLREILPTLFGLLLGCLASTSYDKRQVAARTLGDLVRKLGERVLPEIIPILENGL-NSDH 1934
            .||||.::||||||.|:::..|||:|...|.:||:|||||||::|...|.:::|.||..| .:.:
Yeast  1858 PNTPRAVKEILPTLTGMIVTHLASSSNVLRNIAAQTLGDLVRRVGGNALSQLLPSLEESLIETSN 1922

  Fly  1935 PDQRQGVCIGLSEIMGSTSKEMVLTFIDSLVPTVRKALCDPLPEVREAAAKTFESLHSTVGSRAL 1999
            .|.||||||.|.|::.|.|.|.:..|..::|..:|.||.|....||||||.:|:.....||..|:
Yeast  1923 SDSRQGVCIALYELIESASTETISQFQSTIVNIIRTALIDESATVREAAALSFDVFQDVVGKTAV 1987

  Fly  2000 DEILPFMLQGLSDADPFVAENTLDGLRQVMSIKSKVVLPYLVPQLTSPPVN---TKALSILVSVA 2061
            ||:||::|..|..:|.  ::..|.||:::||.||.|:.|.|:|.|.:||::   ..||..|..||
Yeast  1988 DEVLPYLLHMLESSDN--SDFALLGLQEIMSKKSDVIFPILIPTLLAPPIDAFRASALGSLAEVA 2050

  Fly  2062 GEALIKYLPKILSSLLEALSDAYGYPNEPQENEYCQ--------TVILSVTDETGIRTIMDTLLI 2118
            |.||.|.|..|:::|::|:...       .|:|..:        .|.|||.|:.|:..::..::.
Yeast  2051 GSALYKRLSIIINALVDAIIGT-------SEDESTKGALELALDRVFLSVNDDEGLHPLLQQIMS 2108

  Fly  2119 SANSSDLCTRKSAASLLSAFCIHSPGNYYEYIPQLLRCLLKLLVESDKDILQKSWEALNAVIKGM 2183
            ...|.::..|.:....|..|...:..::..|||..:...:..|.:.|:.::..::.||:.::|.:
Yeast  2109 LLKSDNIEKRIAVLERLPNFFDKTVLDFDVYIPNFVSHAILSLDDEDQRVVNGNFNALSTLLKKV 2173

  Fly  2184 NAAQQICHVSDVRQAVRFAASELEGTELPGFCLPKGITPLLPVFREAILNGLPEEKENAAQGLGE 2248
            :.......|...:|::  |.:..:|.::..|.||:|...:||:|...::.|..:|:|.:|..:.:
Yeast  2174 DKPTLEKLVKPAKQSL--ALTGRQGQDVAAFKLPRGPNCVLPIFLHGLMYGSNDEREESALAIAD 2236

  Fly  2249 VIFLTNAKSLQPSVVHITGPLIRILGDRFNAAVKAAVLETLSILLHKVGVMLKQFLPQLQTTFLK 2313
            |:..|.|.:|:|.|..|||||||::|:||::.:|||:|..|::|..|:.:.|:.|:||||.||:|
Yeast  2237 VVSKTPAANLKPFVSVITGPLIRVVGERFSSDIKAAILFALNVLFIKIPMFLRPFIPQLQRTFVK 2301

  Fly  2314 ALHD-QNRNVRMKAGKALSELVAIHSRAEPLFNEIHNGIKNSDDSSVRETMLHALRSIVSRSGDK 2377
            :|.| .|..:|::|.|||..|:....|.:||..|:..|.|.:.|..|:..||.||..::.::|.|
Yeast  2302 SLSDATNETLRLRAAKALGALIEHQPRVDPLVIELVTGAKQATDEGVKTAMLKALLEVIMKAGSK 2366

  Fly  2378 MSEPIKKQIYVTLL--SMIGHHEDATRSAVGGCLGAILKYIASGHVYDLFNNIILTNNTDDLIVK 2440
            ::|..|..| |.|:  .|:|.: |....|....:|::.:.:::...:.:..:.:|..:.|     
Yeast  2367 LNENSKTNI-VNLVEEEMLGSN-DKLAVAYAKLIGSLSEILSNDEAHKILQDKVLNADLD----- 2424

  Fly  2441 HGHT-----IVLFVALKECPTEVLVLDLPEKITSYVLINILSEKVPIASNAVRAATYLL------ 2494
             |.|     :.|...||:.||.:....|.::..||:|..|.|..|....|...||..||      
Yeast  2425 -GETGKFAILTLNSFLKDAPTHIFNTGLIDEFVSYILNAIRSPDVYFGENGTIAAGKLLLLEGEK 2488

  Fly  2495 -DYYLVNQNEPPIKI--------VMALSRAM---NHSSNDVKQLVAQSCTYLSKNLAANQSSIDV 2547
             ..::......|.||        :..||:|:   ..:|.||::|    ...:.:.||..:....:
Yeast  2489 RSPFVKKDAAEPFKIGDENINLLINELSKAVLQPASNSTDVRRL----ALVVIRTLARFKFDECI 2549

  Fly  2548 LKY---LVPMLVNGTKEKNGYVKSNSELALISILRLRSDDTS------FLKIS 2591
            .:|   :.|.:.:..::....:|..:|.|.:::.:|..:|..      |.|||
Yeast  2550 KQYFDVVGPSVFSCLRDPVIPIKLAAEKAYLALFKLVEEDDMHTFNEWFAKIS 2602

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(3)80FjNP_001015316.1 HEAT repeat 1142..1162 CDD:293787 4/19 (21%)
HEAT repeat 1174..1204 CDD:293787 10/32 (31%)
HEAT repeat 1214..1244 CDD:293787 11/30 (37%)
HEAT repeat 1252..1283 CDD:293787 11/31 (35%)
HEAT repeat 1297..1323 CDD:293787 12/25 (48%)
HEAT repeat 1335..1364 CDD:293787 12/28 (43%)
HEAT 1339..1483 CDD:441023 60/143 (42%)
HEAT repeat 1375..1406 CDD:293787 11/30 (37%)
HEAT repeat 1419..1443 CDD:293787 8/23 (35%)
HEAT 1433..1642 CDD:441023 100/208 (48%)
HEAT repeat 1456..1484 CDD:293787 14/27 (52%)
HEAT repeat 1496..1526 CDD:293787 13/29 (45%)
HEAT repeat 1534..1560 CDD:293787 12/25 (48%)
HEAT repeat 1571..1600 CDD:293787 11/28 (39%)
HEAT 1590..1800 CDD:441023 105/209 (50%)
HEAT repeat 1616..1644 CDD:293787 13/27 (48%)
HEAT repeat 1653..1684 CDD:293787 16/30 (53%)
HEAT repeat 1692..1716 CDD:293787 5/23 (22%)
HEAT repeat 1733..1758 CDD:293787 16/24 (67%)
HEAT 1737..1910 CDD:441023 87/172 (51%)
HEAT repeat 1881..1909 CDD:293787 14/27 (52%)
HEAT 1900..2047 CDD:441023 63/147 (43%)
HEAT repeat 1922..1950 CDD:293787 13/28 (46%)
HEAT repeat 1963..1993 CDD:293787 12/29 (41%)
HEAT repeat 2001..2027 CDD:293787 9/25 (36%)
HEAT repeat 2033..2060 CDD:293787 11/29 (38%)
HEAT repeat 2222..2251 CDD:293787 8/28 (29%)
HEAT repeat 2260..2291 CDD:293787 17/30 (57%)
HEAT repeat 2304..2333 CDD:293787 15/29 (52%)
HEAT repeat 2342..2369 CDD:293787 11/26 (42%)
HEAT repeat 2383..2412 CDD:293787 9/30 (30%)
GCN1NP_011320.3 Gcn1_N 392..670 CDD:463457 63/357 (18%)
HEAT repeat 1327..1353 CDD:293787 10/28 (36%)
HEAT repeat 1368..1397 CDD:293787 10/28 (36%)
HEAT 1397..1551 CDD:441023 71/153 (46%)
HEAT repeat 1411..1435 CDD:293787 8/23 (35%)
HEAT repeat 1448..1476 CDD:293787 14/27 (52%)
HEAT_EZ 1461..1508 CDD:463906 25/46 (54%)
HEAT repeat 1488..1518 CDD:293787 13/29 (45%)
HEAT repeat 1526..1551 CDD:293787 12/24 (50%)
HEAT repeat 1563..1592 CDD:293787 11/28 (39%)
HEAT_2 1575..1671 CDD:433376 46/95 (48%)
HEAT repeat 1601..1636 CDD:293787 17/34 (50%)
HEAT 1615..1748 CDD:441023 62/134 (46%)
HEAT repeat 1645..1676 CDD:293787 16/30 (53%)
HEAT repeat 1684..1710 CDD:293787 5/27 (19%)
HEAT repeat 1723..1748 CDD:293787 16/24 (67%)
HEAT repeat 1763..1789 CDD:293787 19/25 (76%)
HEAT repeat 1830..1856 CDD:293787 9/25 (36%)
HEAT repeat 1868..1896 CDD:293787 14/27 (52%)
HEAT repeat 1909..1938 CDD:293787 13/28 (46%)
HEAT repeat 1951..1981 CDD:293787 12/29 (41%)
HEAT repeat 1989..2013 CDD:293787 9/25 (36%)
HEAT repeat 2019..2049 CDD:293787 11/29 (38%)
HEAT repeat 2060..2088 CDD:293787 5/34 (15%)
HEAT repeat 2099..2128 CDD:293787 3/28 (11%)

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