DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(3)80Fj and gcn1

DIOPT Version :10

Sequence 1:NP_001015316.1 Gene:l(3)80Fj / 3355040 FlyBaseID:FBgn0287182 Length:2630 Species:Drosophila melanogaster
Sequence 2:NP_593669.1 Gene:gcn1 / 2542235 PomBaseID:SPAC18G6.05C Length:2670 Species:Schizosaccharomyces pombe


Alignment Length:2741 Identity:783/2741 - (28%)
Similarity:1322/2741 - (48%) Gaps:364/2741 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 DLTIEHML----NVFKAFIYKEFASVSP-----QKSCKLAVIALGWI-SIIQKQAQRESNIFKTE 136
            ::||.|::    ::...|:.:...:::.     :.:..::...|.|: |:|....::|...:..|
pombe    80 EITINHLVSRLPSIVLPFLVRRLTTIAGRLDRFRSTVSVSFDCLNWVNSMIPNLPEKELQYWILE 144

  Fly   137 KKKLIEYQTLLYQITVISPNQRVTDARTKILYDLWNNTEIFNETMDTL-----FQMESTSNVT-- 194
               |:..|:......:......|.|:..|.....:.:  :|.:.||:|     |.:..|.|..  
pombe   145 ---LLPLQSSFLSYALRDGKPSVADSAIKSTRRCYRS--LFCKKMDSLKKLVSFLLTETENAILP 204

  Fly   195 --------IFCMAMFQFKYKNCNALKLNQYTEKLSEYFVKSMISCKHKPDK----SFIIACSPLL 247
                    :.....:.|........:::|..|..|:...::::..|...:|    .|   |..|.
pombe   205 PKSLPLYGVIISTCYYFHQSPNPRNEISQQAELFSKIMAQNVLMAKPALEKYLYHEF---CYSLG 266

  Fly   248 KSLTDAEFDSYIYPSLQRSILRSPE----NTLQSIGLIFNMLNFDCSR-YAQKVGIVLIKNLYSK 307
            ..|:..:...|:.||:::::|||||    ..|.|:...|.....|.|. ....|....:..|.|.
pombe   267 LLLSVDQLKLYLLPSIEKALLRSPEIIFSGILSSLAHGFADSKVDASSLILSSVLTSFVNGLKSS 331

  Fly   308 GDIARQESLESLKLLSTKCSNWIIVKELLERIFSVLNGS--DGKINVIEYRINILQGAGNLSFNN 370
            ....|:...::.|.||...|:    .|.|.|:.|.|..|  .||:...:.|:..:....:||..:
pombe   332 NAEVRRNCFQTFKDLSANASD----NESLSRVASELITSLRTGKVTASDQRVLFVDALSSLSLKH 392

  Fly   371 IDQDHMPNILNEAVTLFSKALECE--TQEKVICCTLE---------------------------- 405
            ||..   .:|||.:.||:||.|.:  :...:|..||:                            
pombe   393 IDAS---MLLNELLPLFTKAKESDFNSLASLIVKTLKFLLMNGRNPGDKIYDFLSKSLQRPVAHE 454

  Fly   406 -MFGL-------WTQKFIHNLP---DV---VINIFTSGMRLKTTNQIIRQS-------YLEWLL- 448
             ||.|       |      :||   ||   .||.|.:.:.:.|...::..|       ||..:: 
pombe   455 SMFWLTSLATMAW------DLPASDDVQIEFINFFLNNLSILTEKALMSVSGATQNGTYLAPIIY 513

  Fly   449 -------LSIQNAEVNNHISIIQDLISFYTKALQNSSQSCYLSEAACIACILLILEKPSENYNFF 506
                   ||:.|:|..:|...:||                          ||:.|..|..|..|.
pombe   514 LSFGVNKLSVWNSERISHTLELQD--------------------------ILVKLSTPKNNDVFI 552

  Fly   507 WTTVF------DMKKLIFYNEKFTTTAPIPTLCNISLMA-RILINSYPEKIKGKLEPLARTLVSN 564
            :::..      |..||.::.          .||:.:.:: .:|.:::.|          |...|.
pombe   553 FSSKITNKLNDDQSKLWYFQ----------GLCDFAKVSDNLLFSNFVE----------RWFQSV 597

  Fly   565 LCCNSVKVRVYTAKQVKQIINSSSGIEFVKLALCEFGKRINLVNIETDGE--PLIDQFGTSNQVY 627
            :...|...|..:.:.:|.:.::......:::::|.     .|.|...|.|  ..:.:|.::....
pombe   598 IGVFSFASRENSNRALKILKSAILYRPHLRMSICS-----QLWNYHADFEKSKSVGKFDSAKYDE 657

  Fly   628 VDAL---LTLTSI----KHITYEDSVD---VAIDLLLISHHPAIVSNEPYLWETTIQKHLNLDAK 682
            :.:|   |.|:|:    .:.:.::.||   ..::||.:|    ....:.:.|....|.. ..|..
pombe   658 ISSLFQSLILSSMSADTSNFSNQELVDFDKYLVELLFLS----FAFKDKFDWIRFCQVS-KRDPA 717

  Fly   683 NVILAKTNEIVNEYIDNYIASAQYEN-------TISALIRICPNLIVPTVVNNLKNYLSNFSNYN 740
            .::..:.:.|:.| |:..::||..::       :||.::.:.|...:|..||..:|.|.:.:..:
pombe   718 TLVSERIHSIIEE-IELLLSSAIKDSKETAAIASISMIVFVAPEESIPLFVNVFRNQLLHLNISS 781

  Fly   741 VSNEEYLIFLTPDGELFDKSVIPHIDSQYETVRLKRENKVYSYKEQLEEIQLRREIDDKREKEGK 805
            ||:.:..|:.||:|.|:|     ::..:..:.:|.:..|.|..|....|:         |.|:..
pombe   782 VSSTDLEIWKTPEGVLWD-----NVLEKKSSKKLDKNTKDYETKRWEAEV---------RAKQSA 832

  Fly   806 LKTIRYTQKQEEQIKNQMEKELHIKLRITLLYEKLISKISLLKASCSGNGEQMAQHFYSLLDGIL 870
            .|..:.::.|:..:..|::.|..|:.|:.|:...|...:.::::  .|...|:|...:     :.
pombe   833 KKPAKLSKDQQALVDAQLDAEAKIRSRVNLIALSLERGLGIIRS--LGEAVQLAPALW-----VE 890

  Fly   871 NASKSPLCAEVLTDLYIFLHNLCFT----------FQPKLG---RAIALATIKLQSPSCVLKKEF 922
            :|....|...||.....||.||.:.          |..:||   .:.:||:| |.....|...| 
pombe   891 DAIDVLLFHNVLKYSEPFLKNLAYDTFLLTLKASGFSERLGDRSYSSSLASI-LAHTFSVNSSE- 953

  Fly   923 EAFNVNQAINDIIIDLDNHVKSNYLDSPSFSYAFEFL-KRALLLLNTDSDFD-----LISKGIQI 981
               |:.:....|:..|...::.||.:...|:..|..| .....:.|:|.:.:     |:::.::.
pombe   954 ---NIKELTKSILYKLRFAIEQNYFEPQMFACIFPLLYDLTFNITNSDEEDEAELQLLVTEILEF 1015

  Fly   982 LALHTSAGVCCKPQFMPRFGMFKMLLDLLKNNNKLWAQTSAAILQVAKCSNGDNCSSPDNHIISI 1046
            .||::::      ....|..:.|.||.||:.....:.:...::|.:.:   |.:.:..|.. :::
pombe  1016 QALYSAS------LRRMRSKLIKSLLHLLEIAPTQYQENKNSLLSLCE---GLHSTYTDEE-LNL 1070

  Fly  1047 FLQALQHCSDAVRKVALQSLKIMVNGIVNHIKVDNSLEKV-IINRFWVAKHDPEEENRELA---- 1106
            .|..|.|...::|...||:|:..            .|.:. .|...::..:|..|.|..:|    
pombe  1071 LLSNLFHPESSIRSAVLQALQAF------------DLSRFEFIKEIFLELYDDNETNASIAHQIS 1123

  Fly  1107 ----LFLWNTAKFPLPGYVDIINDITHSETCIQKSASESLIPLLAGDEVLKKCVIKKLFSIYKAK 1167
                |....|:.|.|..:      .|.....:|:...:|||.||...|.|.:.:.|:|...|:..
pombe  1124 TQNGLDATETSFFELQIF------FTQDSDYLQQIIGKSLIDLLDEFEELGQFIPKELMRTYREN 1182

  Fly  1168 LSLLPPVLDQF--------DREIEPAIDQWKPRRGIAIAFSTIAFLLSIEDINDIMNFMVSQG-- 1222
            .....|..|::        .|::...     .|..:|::|..|:..||...:...:.|:::..  
pombe  1183 ALPSAPEYDEYGIIKKETIGRDLGRI-----ARESVAVSFFHISKYLSSNLLLPFLEFLLTASEA 1242

  Fly  1223 -----LGDREDVVHKEMLATALKIVDLHGNKAIENLLPVFEDFL--DKAPKSQSYDNIRQAVVIL 1280
                 :.|....|..:||......:...|...:|.|:.:||..|  |..| :.:.|.:|:|.|:|
pombe  1243 EAQIPVTDASQKVSSKMLEAGKLAIFQSGAHQVEALMELFEQKLNVDSLP-TDANDRLREATVVL 1306

  Fly  1281 MGSLARHLEKDDKRIDPIVKRLITSLSTPSQQVQEAVSNCLPHLMPSVKDEAPSMIKKLLHSLAK 1345
            .|::|:||..:|.|:..::..|::.|||||:.||.||:.|||.|:.....::....:.|.:.|..
pombe  1307 FGTVAQHLPSNDPRLAVVMDSLLSVLSTPSESVQLAVAVCLPPLVKKSLGKSKEYYELLSNKLMN 1371

  Fly  1346 SEKYGERRGAAYGIAGIVKGLGILSLKQLDIMSKLTAFIQDKKNYRSREGALFAFEVLCSTLGRL 1410
            |....:::|||||:||:|||.||.:.:..:|:..|:..|.:::|...|:.||||.|.....||..
pombe  1372 STSLADQKGAAYGLAGLVKGYGIKAFQDFNILDSLSELISNRQNATHRQVALFAVEAFSRILGIY 1436

  Fly  1411 FEPYIVHVLPHLLQCFGDPSQYVRQAADDTAKVVMRKLSAHGVKLVLPSLLEALDEDSWRTKTAS 1475
            ||||:..:||.||..|||.:..||:|..|..|.:|.:|||.||||:||:||:.|:|.:||:|.||
pombe  1437 FEPYLPDLLPLLLTSFGDNANEVREATMDAVKQIMSQLSAFGVKLLLPTLLDGLNEYNWRSKKAS 1501

  Fly  1476 VELLGAMAFCAPKQLSSCLPSIVPKLIQVLGDSHTKVQESGGEALKVIGSVIKNPEIQAIVPVLL 1540
            ||:||.|::.||||||..||:|:|||.:||.|||::|:.:..::|...|.||.|||||.:||.||
pombe  1502 VEILGLMSYMAPKQLSVFLPTIIPKLSEVLTDSHSQVRNTANKSLLRFGDVISNPEIQTLVPTLL 1566

  Fly  1541 DALEDPSNNTSTCLQSLLKTKFIHFIDAPSLALIMPVVQRAFMDRSTETRKMAAQIIGNMYSLTD 1605
            .||.|.:..|...|::||||.|:|::|.|||||::|:::....:|:..|::.:|:|.|.|.|||:
pombe  1567 KALSDCTRYTDDALEALLKTSFVHYLDPPSLALVIPILKYGLRERNAGTKRQSAKIFGLMASLTE 1631

  Fly  1606 QKDLAPYLPSIIPGLKSSLLDPVPEVRAVSARALGAMVKGMGESSFENLLPWLMETLTSESSSVD 1670
            .::||.||.|::|.|:..|:||||:.||.:|:|||::::.:||..|..|:|.|...|.||.|.||
pombe  1632 PENLAVYLESLMPRLREVLIDPVPDTRATAAKALGSLIEKLGEKKFPTLIPELFNVLRSECSEVD 1696

  Fly  1671 RSGAAQGLSEVVGGLGVEKMHKLMPEII-STAERVDIAAHVKDGYIMMFIYMPGAFQEEFTPYIG 1734
            |.||||||||::.|||:.::..::|||: :|:..|   .|:::.:|.:.||:|..|...|.||:.
pombe  1697 RQGAAQGLSEILAGLGLARLEDVLPEILKNTSSPV---PHIRESFISLLIYLPATFGSRFQPYLA 1758

  Fly  1735 QIINPILKALADESEFVRDTALKAGQRIVNLYAETAVALLLPELEKGLFDDNWRIRYSSVQLLGD 1799
            :.|.|||..|||:||.|:..:|:|.:.|||.||..:|.||||||||||||:.||||.|||||:||
pombe  1759 RAIPPILSGLADDSELVQTASLRAAKMIVNNYATKSVDLLLPELEKGLFDNAWRIRLSSVQLVGD 1823

  Fly  1800 LLYRISGVSGKMTTETASEDDNFGTEHSHTAIIHFLGDERRNRVLSGLYMGRSDVSLMVRQAALH 1864
            |:::::|::.|...|. .|::...::.|..|::..:|.||.:|:||.||:.|.|::.:||..|:.
pombe  1824 LVFKLAGINRKALQED-EEEEGTHSDVSRKALLDIIGQERHDRILSTLYIVRQDIAAVVRTPAIQ 1887

  Fly  1865 VWKVVVTNTPRTLREILPTLFGLLLGCLASTSYDKRQVAARTLGDLVRKLGERVLPEIIPILENG 1929
            :||.:|.|||||:|||||||..:::..|.|:|.|:|.:..::||||::|.|..|||:::|:|:.|
pombe  1888 IWKAIVVNTPRTVREILPTLTSIIVSNLNSSSNDRRTMCVKSLGDLLKKAGFDVLPQLLPVLKQG 1952

  Fly  1930 LNSDHPDQRQGVCIGLSEIMGSTSKEMVLTFIDSLVPTVRKALCDPLPEVREAAAKTFESLHSTV 1994
            |.|.:...|.||||.|.|::.|.:.|.:..:.|..|..||:||.|...||||.||:.|:||.|.:
pombe  1953 LESANSGDRIGVCIALEELINSATPEQLEIYSDDFVYAVRRALMDGDLEVRETAAEAFDSLQSIL 2017

  Fly  1995 GSRALDEILPFMLQGLSDADPFVAENTLDGLRQVMSIKSKVVLPYLVPQLTSPPV---NTKALSI 2056
            |.||:|::||.:|:.|...:.  :|..|..||:::|.:|..:.|.|:|.|...||   |.:|||.
pombe  2018 GDRAVDDVLPQLLKLLESENQ--SEQALSALREIISRRSSTIFPVLIPTLIKKPVSAFNARALSS 2080

  Fly  2057 LVSVAGEALIKYLPKILSSLLEALSDAYGYPNEPQENEYCQTVILSVTDETGIRTIMDTLLISAN 2121
            |..|||..|.|.||.||::|:|:...:.| .:....|.....|.|||.|:.|::.:|......:.
pombe  2081 LAQVAGVTLNKRLPSILNALMESSLASTG-DDLVALNGAIDKVNLSVKDQEGLQILMAHFYSFSE 2144

  Fly  2122 SSDLCTRKSAASLLSAFCIHSPGNYYEYIPQLLRCLLKLLVESDKDILQKSWEALNAVIKGMNAA 2186
            |.|...|..||..:..|..:...:||.|:...:|..:.|..:..:|::..:..|.|.::..:...
pombe  2145 SEDFRKRLFAAEHMLVFFQNCKLDYYRYVGDWVRHFITLFEDKSQDVVVAAVAAQNTLVSALRKD 2209

  Fly  2187 QQICHVSDVRQAVRFAASELEGTELPGFCLPKGITPLLPVFREAILNGLPEEKENAAQGLGEVIF 2251
            |....||....::|...|  :|..||.|.:.:|:..:||:|...:::|..:::|.:|.|:.:::.
pombe  2210 QLDSLVSIAYHSLRDVGS--QGVNLPAFEVAQGVNSILPIFLYGLMHGTMDQREQSALGIADIVL 2272

  Fly  2252 LTNAKSLQPSVVHITGPLIRILGDRFNAAVKAAVLETLSILLHKVGVMLKQFLPQLQTTFLKALH 2316
            .|....|:|.|..||||||||:|:||...||.|:|.||:|:|.|:...|:.||||||.||.|.|.
pombe  2273 KTEPSKLRPFVTQITGPLIRIIGERFPVEVKCAILYTLNIILSKISTFLRPFLPQLQRTFAKCLG 2337

  Fly  2317 DQNRNV-RMKAGKALSELVAIHSRAEPLFNEIHNGIKNSDDSSVRETMLHALRSIVSRSGDKMSE 2380
            |.:..| |.:|..||..|:.:.:|..|:..|:.:|.: :.|:.||:.||:||.::||:||..|:|
pombe  2338 DPSSEVIRSRAATALGTLITLQTRLAPIITELVSGAR-TPDAGVRKAMLNALFAVVSKSGQNMNE 2401

  Fly  2381 PIKKQIYVTLLSMIGHHEDATRSAVGGCLGAILKYIASGHVYDLFNNIILTNNTDDLIVKHGHTI 2445
            ...:.| ..||..|...............||:..::.......|..:.:|:..    |......:
pombe  2402 ASAEAI-EQLLDEISAESSEHMVICAKLYGALFSHLPDAQAKQLLESKVLSLE----IQSEFSVL 2461

  Fly  2446 VLFVALKECPTEVLVLDLPEKITSYVLINILSEKVPIASNAVRA---------------ATYLLD 2495
            :|..|:|....:::.|.|.:.:.|.:....|.::|.||.|.:.|               |..|::
pombe  2462 ILNAAVKFGSQKIIELKLSDIVCSIISTASLQKEVTIAENGILALGKALLADIPQSFGNAKNLVE 2526

  Fly  2496 YYLVNQNEPPIKIVMALSRAMNHSSNDVKQLVAQSCTYLSKNLAANQSSIDV-LKYLVPMLVNGT 2559
            ...||...||            .:|.|.::|.......:||.   |.|.|.. :..|.|.:....
pombe  2527 ALKVNIEAPP------------STSQDSRRLALLIIRVVSKE---NYSLIKPHISILAPAIFGCV 2576

  Fly  2560 KEKNGYVKSNSELALISILRLRSDDTSFLKISGLLESGARDSLND------VVLKVLKR---TSS 2615
            :.....||..:|.|.:::.:|..||:...|....||.....|..|      |.|...:|   .|.
pombe  2577 RAIVIPVKLAAEAAFLALFQLVEDDSVLNKYIETLEGPRARSFVDYSRRVAVKLAAAERDRINSG 2641

  Fly  2616 QSIIKEEELDD 2626
            ...:|.||::|
pombe  2642 SERVKLEEVED 2652

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(3)80FjNP_001015316.1 HEAT repeat 1142..1162 CDD:293787 8/19 (42%)
HEAT repeat 1174..1204 CDD:293787 6/37 (16%)
HEAT repeat 1214..1244 CDD:293787 5/36 (14%)
HEAT repeat 1252..1283 CDD:293787 11/32 (34%)
HEAT repeat 1297..1323 CDD:293787 12/25 (48%)
HEAT repeat 1335..1364 CDD:293787 10/28 (36%)
HEAT 1339..1483 CDD:441023 66/143 (46%)
HEAT repeat 1375..1406 CDD:293787 10/30 (33%)
HEAT repeat 1419..1443 CDD:293787 11/23 (48%)
HEAT 1433..1642 CDD:441023 105/208 (50%)
HEAT repeat 1456..1484 CDD:293787 16/27 (59%)
HEAT repeat 1496..1526 CDD:293787 12/29 (41%)
HEAT repeat 1534..1560 CDD:293787 11/25 (44%)
HEAT repeat 1571..1600 CDD:293787 9/28 (32%)
HEAT 1590..1800 CDD:441023 103/210 (49%)
HEAT repeat 1616..1644 CDD:293787 13/27 (48%)
HEAT repeat 1653..1684 CDD:293787 18/30 (60%)
HEAT repeat 1692..1716 CDD:293787 6/24 (25%)
HEAT repeat 1733..1758 CDD:293787 11/24 (46%)
HEAT 1737..1910 CDD:441023 83/172 (48%)
HEAT repeat 1881..1909 CDD:293787 10/27 (37%)
HEAT 1900..2047 CDD:441023 59/146 (40%)
HEAT repeat 1922..1950 CDD:293787 12/27 (44%)
HEAT repeat 1963..1993 CDD:293787 15/29 (52%)
HEAT repeat 2001..2027 CDD:293787 7/25 (28%)
HEAT repeat 2033..2060 CDD:293787 12/29 (41%)
HEAT repeat 2222..2251 CDD:293787 7/28 (25%)
HEAT repeat 2260..2291 CDD:293787 19/30 (63%)
HEAT repeat 2304..2333 CDD:293787 15/29 (52%)
HEAT repeat 2342..2369 CDD:293787 10/26 (38%)
HEAT repeat 2383..2412 CDD:293787 5/28 (18%)
gcn1NP_593669.1 Gcn1_N 376..723 CDD:463457 74/411 (18%)
HEAT repeat 1482..1510 CDD:293787 16/27 (59%)
HEAT_EZ 1495..1542 CDD:463906 28/46 (61%)
HEAT 1521..1668 CDD:441023 69/146 (47%)
HEAT repeat 1522..1552 CDD:293787 12/29 (41%)
HEAT repeat 1560..1585 CDD:293787 10/24 (42%)
HEAT_EZ 1615..1668 CDD:463906 26/52 (50%)
HEAT repeat 1642..1670 CDD:293787 13/27 (48%)
HEAT 1644..1782 CDD:441023 62/140 (44%)
HEAT repeat 1679..1710 CDD:293787 18/30 (60%)
HEAT repeat 1718..1744 CDD:293787 7/28 (25%)
HEAT repeat 1757..1782 CDD:293787 11/24 (46%)
HEAT repeat 1799..1823 CDD:293787 19/23 (83%)
HEAT repeat 1904..1932 CDD:293787 10/27 (37%)
HEAT 1943..2085 CDD:441023 57/143 (40%)
HEAT repeat 1945..1973 CDD:293787 12/27 (44%)
HEAT repeat 1986..2016 CDD:293787 15/29 (52%)
HEAT repeat 2024..2048 CDD:293787 7/25 (28%)
HEAT repeat 2058..2084 CDD:293787 11/25 (44%)

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