Protein Alignment l(3)80Fj and l(3)80Fj

DIOPT Version :10

• Sequence 1: NP_001015316.1
• Gene: l(3)80Fj / 3355040
• FlyBaseID: FBgn0287182
• Length: 2630
• Species: Drosophila melanogaster
• Sequence 2: XP_321391.5
• Gene: l(3)80Fj / 1281475
• VectorBaseID: AGAMI1_010264
• Length: 2666
• Species: Anopheles gambiae
• Alignment Length: 2675
• Identity: 1563/2675 - (58%)
• Similarity: 1948/2675 - (72%)
• Gaps: 58/2675 - (2%)

  Fly     1 MVDEQLSAALRDLPGRVLNVPVEERQHLFQNVSSVLKNSGINSTIIRGICKVIGTTITKYKDPTS 65
            |.|.:|:.||:|||.||||||||||..|||||.:||.|.|||:||:||||||||||:||||||.|
Mosquito     1 MADAELAKALKDLPNRVLNVPVEERPELFQNVIAVLPNPGINATIVRGICKVIGTTLTKYKDPES 65

  Fly    66 QRIVRDLIVDLVTIHHDLTIEHMLNVFKAFIYKEFASVSPQKSCKLAVIALGWISIIQKQAQRES 130
            |.:||||:|.::..|.||..||...|.||.:.|:.||..|.|..:.:.:||||.:::...|..|:
Mosquito    66 QALVRDLLVAVLKQHPDLAYEHFNAVLKALLTKDLASAPPVKGAQASALALGWANLVALHADHET 130

  Fly   131 NIFKTEKKKLIEYQTLLYQITVISPNQRVTDARTKILYDLWNNTE--IFNETMDTLFQMESTSNV 193
            .:.|.|..||::.|..|||:::.|..|:|:|.....:.|.:.:.:  :.....|.|...|.:|.|
Mosquito   131 AVGKKEFPKLLDIQAGLYQLSLTSGMQKVSDKAYSFVRDFFASGDDGLAQRYFDRLLATEPSSGV 195

  Fly   194 TIFCMAMFQFKYKNCNA----LKLNQYTEKLSEYFVKSMISCKHKPDKSFIIACSPLLKSLTDAE 254
            .:....:.:|..:...|    ..|.|:..||.::.||.:|:.|.||..|.|||||||||::|..|
Mosquito   196 IVMLCTIVRFVREELGAEAAESLLTQHKTKLLDHLVKGLITVKTKPHASDIIACSPLLKAITKDE 260

  Fly   255 FDSYIYPSLQRSILRSPENTLQSIGLIFNMLNFDCSRYAQKVGIVLIKNLYSKGDIARQESLESL 319
            ..:.:.|:||||:|||.|..|:::|.|.|.|..|.|.||..:|..|::||.||.:..|||::|||
Mosquito   261 LKTVVVPALQRSMLRSAEVILRAVGAIVNELELDVSDYALDLGKPLVQNLASKEETVRQEAVESL 325

  Fly   320 KLLSTKCSNWIIVKELLERIFSVLNGSDGKINVIEYRINILQGAGNLSFNNIDQDHMPNILNEAV 384
            |.::.||.....::.||:.:|:|||||.|||.|.|.|||:||||||||:|.|....:..||....
Mosquito   326 KQVALKCGTAGAIEALLKEVFAVLNGSGGKITVAELRINLLQGAGNLSYNKIPPQKVQTILPAVC 390

  Fly   385 TLFSKALECETQEKVICCTLEMFGLWTQKFIHNLPDVVINIFTSGMRLKTTNQIIRQSYLEWLLL 449
            ..|||.:|.|.||||:|..||||||||.....::|:.::.:|..||..|.  |.||.|||:|.|.
Mosquito   391 DQFSKVIEAEIQEKVVCHALEMFGLWTVYHRGDIPNKIVQLFRKGMDAKA--QTIRTSYLQWFLS 453

  Fly   450 SIQNAEVNNHISIIQDLISFYTKALQNSSQSCYLSEAACIACILLILE-KPSENYNFFWTTVFDM 513
            .:.:.::.:.......|.....:|.|:.:|:..:||....|||||:.. ...|....||..|.|.
Mosquito   454 CLHDGKLPSGADFTATLSKIVERAAQSPAQTPVVSEGVGAACILLLTNGSVCEKLKDFWNIVLDT 518

  Fly   514 KKLIFYNEKFTTTAPIPTLCNISLMARILINSYPEKIKG---KLEPLARTLVSNLCCNS--VKVR 573
            .|..|.:|:|.:|....|.|.:.::...|:..:..::||   .::||.|  .:.:|..|  .|||
Mosquito   519 GKSPFLSERFLSTTNAETRCYVMVICEQLLIKHRSELKGGDSAIDPLIR--AATICAMSAQTKVR 581

  Fly   574 VYTAKQVKQIINSSSGIEFVKLALCEFGKRINLVNIETDGEPLIDQFGTSNQVYVDALLTLTSIK 638
            .|....|.:|:||..|:...|..|.|..:......|:.:|||| ::.....|..|||:.|:.:::
Mosquito   582 RYCLPLVNKIVNSEQGVPLAKCLLAELTRYAESSKIQCEGEPL-EEGVPPAQALVDAIYTVCNVE 645

  Fly   639 HITYEDSVDVAIDLLLISHHPAIVSNEPYLWETTIQKHLNLDAKNVILAKTNEIVNEYIDNYIAS 703
            .:...|:..:|:..||.|||||.||....|||:.:::: .|:.|..|...|.:|...:...|.|:
Mosquito   646 GVANPDAQSLALGALLCSHHPAAVSVRGDLWESILERY-GLNGKQFIALNTAQIEETFFSGYKAA 709

  Fly   704 AQYENTISALIRICPNLIVPTVVNNLKNYLSNFSNYNVSNEEYLIFLTPDGELFDKSVIPHIDSQ 768
            |.||||::.|.||.|..|:..:|.|:...|:|....||::|||..:|||||||:||||||..|.|
Mosquito   710 AMYENTLATLSRISPEQILSVLVKNVTEQLNNSRMSNVTDEEYFTYLTPDGELYDKSVIPSADEQ 774

  Fly   769 YETVRLKRENKVYSYKEQLEEIQLRREIDDKREKEGKLKTIRYTQKQEEQIKNQMEKELHIKLRI 833
            .:|..||||||.|||||||||:|||||:::||.|||..|..:.|.||:|.|..|.|||..||.|:
Mosquito   775 IQTAHLKRENKAYSYKEQLEELQLRRELEEKRRKEGTWKPPQLTPKQKEVIDKQREKENAIKARL 839

  Fly   834 TLLYEKLISKISLLKASCSGNGEQMAQHFYSLLDGILNASKSPLCAEVLTDLYIFLHNLCF-TFQ 897
            ..|::.:.:.||.::.:..|..:|:...|.:||..:|....|||.|..:..||..|.::|| ..:
Mosquito   840 KALHDTITTLISQIEGAAKGTPKQLPLFFPALLPSVLRVFSSPLAAPAMVKLYFRLKDICFGEER 904

  Fly   898 PKLGRAIALATIKLQSPSCVLKKEFEAFNVNQAINDIIIDLDNHVKSNY-------------LDS 949
            .:|||.||:|||:|..|.|.|::.:...|:.:.::||::.|.:.....|             ||:
Mosquito   905 AELGRDIAIATIRLSKPHCDLEESWCTANLVELVSDILVALYDETIDMYNVHREEEGSKRYLLDA 969

  Fly   950 PSFSYAFEFLKRALLLLNTDSDFDLISKGIQILALHTS-----------AGVCCKPQFMPRFGMF 1003
            |:|||.||||||||.:.....|..|:..|:||:|.|..           |.| ..|.:|||..|.
Mosquito   970 PAFSYTFEFLKRALTMPEAKKDESLLINGVQIIAYHAQLKGDTVDGKDLADV-YHPAYMPRLEMV 1033

  Fly  1004 KMLLDLL-KNNNKLWAQTSAAILQVAK-CSNGDNCSSPDNHIISIFLQALQHCSDAVRKVALQSL 1066
            ::||.|: ::..::..|..||:|.||: ||..:..:..|...|...|.|||...||||.|:|::|
Mosquito  1034 RLLLRLVQQHRGRVQTQAVAALLDVAESCSGREYTARADLREIDALLVALQEELDAVRDVSLRAL 1098

  Fly  1067 KIMVNGIVNHIKVDNSLEKVIINRFWVAKHDPEEENRELALFLWNTAKFPLPGYV--DIINDITH 1129
            .||:: ::..|..|......:..|.||||||...:.:.||..:|....:.:|..:  :::.||.|
Mosquito  1099 AIMID-VLPSIADDYEFGLRLTRRLWVAKHDLSPDIKLLATGIWQDGGYEVPIVMADELMKDIIH 1162

  Fly  1130 SETCIQKSASESLIPLLAGDEVLKKCVIKKLFSIYKAKLSLLPPVLDQFDREIEPAIDQWKPRRG 1194
            .|.|:||:|:.:|:.:|..|....:.|:::|..||:.|:.::|..|||||||||||||.|.||||
Mosquito  1163 PELCVQKAAAAALVSILVEDSSTIEGVVEQLLEIYREKVVMIPAKLDQFDREIEPAIDPWGPRRG 1227

  Fly  1195 IAIAFSTIAFLLSIEDINDIMNFMVSQGLGDREDVVHKEMLATALKIVDLHGNKAIENLLPVFED 1259
            :|||..:|:..|:.|.:..::.|||..||.||:::|||||||.:|.|||.||.:.:..|||.||.
Mosquito  1228 VAIALGSISPFLTPELVKSVIQFMVRYGLRDRQEIVHKEMLAASLAIVDHHGKENVTYLLPTFEY 1292

  Fly  1260 FLDKAPKSQSYDNIRQAVVILMGSLARHLEKDDKRIDPIVKRLITSLSTPSQQVQEAVSNCLPHL 1324
            ||||||...:|||||||||||||||||||:::|:||.||:.||:.:|.||||||||||:||:|||
Mosquito  1293 FLDKAPSKGAYDNIRQAVVILMGSLARHLDREDERIQPIIDRLLAALETPSQQVQEAVANCIPHL 1357

  Fly  1325 MPSVKDEAPSMIKKLLHSLAKSEKYGERRGAAYGIAGIVKGLGILSLKQLDIMSKLTAFIQDKKN 1389
            :|:|||.||.::||||..|.||||||.||||||||||:|||||||||||||||||||.:||||||
Mosquito  1358 IPAVKDRAPEIVKKLLQQLVKSEKYGVRRGAAYGIAGVVKGLGILSLKQLDIMSKLTQYIQDKKN 1422

  Fly  1390 YRSREGALFAFEVLCSTLGRLFEPYIVHVLPHLLQCFGDPSQYVRQAADDTAKVVMRKLSAHGVK 1454
            ::.|||||||||:||||||||||||||||||||||||||.|.|||||||:.||.||.||||||||
Mosquito  1423 FKYREGALFAFEMLCSTLGRLFEPYIVHVLPHLLQCFGDSSVYVRQAADECAKTVMAKLSAHGVK 1487

  Fly  1455 LVLPSLLEALDEDSWRTKTASVELLGAMAFCAPKQLSSCLPSIVPKLIQVLGDSHTKVQESGGEA 1519
            |||||||.||||||||||||||||||:||||||||||||||||||||::||||||.||||:|..|
Mosquito  1488 LVLPSLLNALDEDSWRTKTASVELLGSMAFCAPKQLSSCLPSIVPKLMEVLGDSHIKVQEAGANA 1552

  Fly  1520 LKVIGSVIKNPEIQAIVPVLLDALEDPSNNTSTCLQSLLKTKFIHFIDAPSLALIMPVVQRAFMD 1584
            |:|||||||||||||||||||.||||||:.||.||||||:|||:|||||||||||||||||||||
Mosquito  1553 LRVIGSVIKNPEIQAIVPVLLTALEDPSSKTSACLQSLLETKFVHFIDAPSLALIMPVVQRAFMD 1617

  Fly  1585 RSTETRKMAAQIIGNMYSLTDQKDLAPYLPSIIPGLKSSLLDPVPEVRAVSARALGAMVKGMGES 1649
            |||||||||||||||||||||||||.||||:||||||:||||||||||.||||||||||:|||||
Mosquito  1618 RSTETRKMAAQIIGNMYSLTDQKDLTPYLPNIIPGLKTSLLDPVPEVRGVSARALGAMVRGMGES 1682

  Fly  1650 SFENLLPWLMETLTSESSSVDRSGAAQGLSEVVGGLGVEKMHKLMPEIISTAERVDIAAHVKDGY 1714
            |||:||||||:|||||||||||||||||||||||||||||:||||||||:||||.|||.||||||
Mosquito  1683 SFEDLLPWLMQTLTSESSSVDRSGAAQGLSEVVGGLGVEKLHKLMPEIIATAERTDIAPHVKDGY 1747

  Fly  1715 IMMFIYMPGAFQEEFTPYIGQIINPILKALADESEFVRDTALKAGQRIVNLYAETAVALLLPELE 1779
            ||||||||.||..:|||||||||||||||||||:|:||||||||||||||||||:|:.|||||||
Mosquito  1748 IMMFIYMPSAFPNDFTPYIGQIINPILKALADENEYVRDTALKAGQRIVNLYAESAITLLLPELE 1812

  Fly  1780 KGLFDDNWRIRYSSVQLLGDLLYRISGVSGKMTTETASEDDNFGTEHSHTAIIHFLGDERRNRVL 1844
            |||||||||||||||||||||||:||||||||||:|||||||||||.||.|||..||.:||||||
Mosquito  1813 KGLFDDNWRIRYSSVQLLGDLLYKISGVSGKMTTQTASEDDNFGTEQSHKAIIRSLGADRRNRVL 1877

  Fly  1845 SGLYMGRSDVSLMVRQAALHVWKVVVTNTPRTLREILPTLFGLLLGCLASTSYDKRQVAARTLGD 1909
            :||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||
Mosquito  1878 AGLYMGRSDVSLMVRQAALHVWKVVVTNTPRTLREILPTLFSLLLGCLASTSYDKRQVAARTLGD 1942

  Fly  1910 LVRKLGERVLPEIIPILENGLNSDHPDQRQGVCIGLSEIMGSTSKEMVLTFIDSLVPTVRKALCD 1974
            ||||||||||||||||||.||:||..||||||||||||||.|||::|||||::||||||||||.|
Mosquito  1943 LVRKLGERVLPEIIPILERGLSSDQADQRQGVCIGLSEIMASTSRDMVLTFVNSLVPTVRKALAD 2007

  Fly  1975 PLPEVREAAAKTFESLHSTVGSRALDEILPFMLQGLSDADPFVAENTLDGLRQVMSIKSKVVLPY 2039
            ||||||.||||||:|||:|||:|||::|||.||:.|.|.||.|||.|||||||||:|||:|||||
Mosquito  2008 PLPEVRHAAAKTFDSLHTTVGARALEDILPSMLESLGDPDPDVAEWTLDGLRQVMAIKSRVVLPY 2072

  Fly  2040 LVPQLTSPPVNTKALSILVSVAGEALIKYLPKILSSLLEALSDAYGYPNEPQENEYCQTVILSVT 2104
            |:||||:.||||||||||.|||||||.|||||||.:||.||:.|.|.|.|.||.||||.|||||:
Mosquito  2073 LIPQLTAKPVNTKALSILASVAGEALTKYLPKILPALLAALAGAQGTPEEVQELEYCQAVILSVS 2137

  Fly  2105 DETGIRTIMDTLLISANSSDLCTRKSAASLLSAFCIHSPGNYYEYIPQLLRCLLKLLVESDKDIL 2169
            ||.||||||||::.|..|....||::||:||.|||.||||:|.:|:|||||.||.||.:||:|:|
Mosquito  2138 DEVGIRTIMDTVMESTKSETPETRRAAATLLCAFCTHSPGDYSQYVPQLLRGLLWLLADSDRDVL 2202

  Fly  2170 QKSWEALNAVIKGMNAAQQICHVSDVRQAVRFAASEL-EGTELPGFCLPKGITPLLPVFREAILN 2233
            |.||:|||||.|.:::||||.||:||||||:||:|:| :|.||||||||||||||||||||||||
Mosquito  2203 QPSWDALNAVTKTLDSAQQIAHVTDVRQAVKFASSDLPKGGELPGFCLPKGITPLLPVFREAILN 2267

  Fly  2234 GLPEEKENAAQGLGEVIFLTNAKSLQPSVVHITGPLIRILGDRFNAAVKAAVLETLSILLHKVGV 2298
            |||||||||||||||||.||:..|||||||||||||||||||||||.|||||||||:|||||||:
Mosquito  2268 GLPEEKENAAQGLGEVIKLTSPASLQPSVVHITGPLIRILGDRFNAGVKAAVLETLAILLHKVGI 2332

  Fly  2299 MLKQFLPQLQTTFLKALHDQNRNVRMKAGKALSELVAIHSRAEPLFNEIHNGIKNSDDSSVRETM 2363
            |||||||||||||||||||..|.||:|||.||:||:.||:|.:|||.|:||||||:|||:|||||
Mosquito  2333 MLKQFLPQLQTTFLKALHDPARLVRIKAGHALAELIVIHTRPDPLFVEMHNGIKNADDSAVRETM 2397

  Fly  2364 LHALRSIVSRSGDKMSEPIKKQIYVTLLSMIGHHEDATRSAVGGCLGAILKYIASGHVYDLFNNI 2428
            |.|||.||:.:||||:||::||||.||..|:.:.||.:|:|..||.||:.:::....|.|...|.
Mosquito  2398 LQALRGIVTPAGDKMTEPLRKQIYTTLAGMLDYTEDVSRAAAAGCFGALCRWLTPDQVDDALTNH 2462

  Fly  2429 ILTNN-TDDLIVKHGHTIVLFVALKECPTEVLVLDLPEKITSYVLINILSEKVPIASNAVRAATY 2492
            :|..: .||..::||.|..|||||||.|..:::.....||...:...::|:|:|:|.|.|||..|
Mosquito  2463 LLNEDYGDDATLRHGRTAALFVALKEYPAAIVLPKYETKICKVITGALVSDKIPVAMNGVRAGGY 2527

  Fly  2493 LLDYYLVNQNEPPIKIVMAL----SRAMNHSSNDVKQLVAQSCTYLSKNLAANQSSIDVLKYLVP 2553
            ||.|.:.:..   .|:..||    .::||||||:||||:|::||||::.:.|.:.:.:.||..:|
Mosquito  2528 LLQYGMADDG---AKLCTALIAPFVKSMNHSSNEVKQLLAKTCTYLARVVPAERIAPEYLKLAIP 2589

  Fly  2554 MLVNGTKEKNGYVKSNSELALISILRLRSDDTSFLKISGLLESGARDSLNDVVLKVLKRTSSQSI 2618
            |||||||||||||:||||:||:.:||||..:....:...|||.|||:||::||.|||::.:.|:.
Mosquito  2590 MLVNGTKEKNGYVRSNSEIALVHVLRLRDGEDFHQRCLTLLEPGARESLSEVVSKVLRKVAMQAA 2654

  Fly  2619 IKEEELDDTL 2628
            .||||||||:
Mosquito  2655 GKEEELDDTI 2664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(3)80Fj	NP_001015316.1	HEAT repeat	1142..1162	CDD:293787	5/19 (26%)
		HEAT repeat	1174..1204	CDD:293787	22/29 (76%)
		HEAT repeat	1214..1244	CDD:293787	17/29 (59%)
		HEAT repeat	1252..1283	CDD:293787	23/30 (77%)
		HEAT repeat	1297..1323	CDD:293787	17/25 (68%)
		HEAT repeat	1335..1364	CDD:293787	21/28 (75%)
		HEAT	1339..1483	CDD:441023	124/143 (87%)
		HEAT repeat	1375..1406	CDD:293787	24/30 (80%)
		HEAT repeat	1419..1443	CDD:293787	19/23 (83%)
		HEAT	1433..1642	CDD:441023	185/208 (89%)
		HEAT repeat	1456..1484	CDD:293787	25/27 (93%)
		HEAT repeat	1496..1526	CDD:293787	22/29 (76%)
		HEAT repeat	1534..1560	CDD:293787	21/25 (84%)
		HEAT repeat	1571..1600	CDD:293787	28/28 (100%)
		HEAT	1590..1800	CDD:441023	189/209 (90%)
		HEAT repeat	1616..1644	CDD:293787	25/27 (93%)
		HEAT repeat	1653..1684	CDD:293787	28/30 (93%)
		HEAT repeat	1692..1716	CDD:293787	20/23 (87%)
		HEAT repeat	1733..1758	CDD:293787	22/24 (92%)
		HEAT	1737..1910	CDD:441023	157/172 (91%)
		HEAT repeat	1881..1909	CDD:293787	26/27 (96%)
		HEAT	1900..2047	CDD:441023	120/146 (82%)
		HEAT repeat	1922..1950	CDD:293787	23/27 (85%)
		HEAT repeat	1963..1993	CDD:293787	26/29 (90%)
		HEAT repeat	2001..2027	CDD:293787	17/25 (68%)
		HEAT repeat	2033..2060	CDD:293787	21/26 (81%)
		HEAT repeat	2222..2251	CDD:293787	28/28 (100%)
		HEAT repeat	2260..2291	CDD:293787	29/30 (97%)
		HEAT repeat	2304..2333	CDD:293787	22/28 (79%)
		HEAT repeat	2342..2369	CDD:293787	21/26 (81%)
		HEAT repeat	2383..2412	CDD:293787	14/28 (50%)
l(3)80Fj	XP_321391.5	None