Protein Alignment Gprk1 and SCH9

DIOPT Version :10

• Sequence 1: NP_001036438.1
• Gene: Gprk1 / 3355013
• FlyBaseID: FBgn0260798
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_012075.1
• Gene: SCH9 / 856612
• SGDID: S000001248
• Length: 824
• Species: Saccharomyces cerevisiae
• Alignment Length: 627
• Identity: 180/627 - (28%)
• Similarity: 262/627 - (41%)
• Gaps: 131/627 - (20%)

  Fly    19 KSKCTPAARASKKL-------NLPDPSVRSVMYKYLEKEGELN-------FHKIFNEVLGYLLFK 69
            |.|.....|:|.:|       ::.|||.||.........|..|       .||...:|||.....
Yeast   279 KKKPLYTHRSSSQLDQLNSCSSVTDPSKRSSNSSSGSSNGPKNDSSHPIWHHKTTFDVLGSHSEL 343

  Fly    70 DFCENDSEEPIQQLKFFEQIKLFEKTECYDERKKMARDIYDNFIMEEMLSHTYEYSKHAVASVQK 134
            |....|:   .....|..|::|:.                    |...|:|..::..|:
Yeast   344 DISVYDA---AHDHMFLGQVRLYP--------------------MIHNLAHASQHQWHS------ 379

  Fly   135 YLLKNEVPVDLFEPYLEEIFTQLKGKPFKKFLESD---KFTRFCQWKNLELNIQLTMNDFSVHRI 196
                                  ||.:...:.:..|   |:| :.|.|......|    ||.|.|:
Yeast   380 ----------------------LKPRVIDEVVSGDILIKWT-YKQTKKRHYGPQ----DFEVLRL 417

  Fly   197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTYA 261
            :|:|.||:||..:|.||.::||||.|.||.|..|......:.|||:| ..:.....||||.:.::
Yeast   418 LGKGTFGQVYQVKKKDTQRIYAMKVLSKKVIVKKNEIAHTIGERNIL-VTTASKSSPFIVGLKFS 481

  Fly   262 FHTPDKLCFILDLMNGGDLHYHLSQHGIFSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANILL 326
            |.||..|..:.|.|:||:|.:||.:.|.||||..|||.||::|.|||:|...||||||||.||||
Yeast   482 FQTPTDLYLVTDYMSGGELFWHLQKEGRFSEDRAKFYIAELVLALEHLHDNDIVYRDLKPENILL 546

  Fly   327 DENGHIRISDLGLACDFSKKKPHASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYKLLKGHSP 391
            |.||:|.:.|.||:....|.:.:...||..|:|||:|...|.|....|::|.|.:::::..|.||
Yeast   547 DANGNIALCDFGLSKADLKDRTNTFCGTTEYLAPELLLDETGYTKMVDFWSLGVLIFEMCCGWSP 611

  Fly   392 F---RQHKTKDKLEIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSKRLGCMGNGADEVKMHNF 453
            |   ...|...|:...|:....:|     .|.|.::.::.||.|:...|||.:.:|. |::.|.|
Yeast   612 FFAENNQKMYQKIAFGKVKFPRDV-----LSQEGRSFVKGLLNRNPKHRLGAIDDGR-ELRAHPF 670

  Fly   454 FCGIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEE-DTKGIKLNDADQDLYKMFSLTISER 517
            |..|||..:..:|..||..|     :.....|..:||.| .|......:..|.:  |.:..:|..
Yeast   671 FADIDWEALKQKKIPPPFKP-----HLVSETDTSNFDPEFTTASTSYMNKHQPM--MTATPLSPA 728

  Fly   518 WQQEVSETVFDTVNTETDKLEQKRKLKQKQHFDADEKESDCILHGYIKKLGGSFASLWQTKYAKL 582
            .|.:.:...|...:...:.:...||..|..:|...                |||.
Yeast   729 MQAKFAGFTFVDESAIDEHVNNNRKFLQNSYFMEP----------------GSFI---------- 767

  Fly   583 YPNRLELHSESGN-NKP---ELIFMDQVEDISSDFILHKNEN 620
                      .|| |.|   ::|..|..|||:..|...||.|
Yeast   768 ----------PGNPNLPPDEDVIDDDGDEDINDGFNQEKNMN 799

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	29/172 (17%)
		Protein Kinases, catalytic domain	185..531	CDD:473864	127/349 (36%)
		PH_GRK2_subgroup	552..675	CDD:269946	16/73 (22%)
SCH9	NP_012075.1	YPK1_N_like	181..407	CDD:212165	33/179 (18%)
		STKc_Sck1_like	418..738	CDD:270738	121/333 (36%)