Protein Alignment Gprk1 and Grk1

DIOPT Version :9

• Sequence 1: NP_001036438.1
• Gene: Gprk1 / 3355013
• FlyBaseID: FBgn0260798
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_112358.1
• Gene: Grk1 / 81760
• RGDID: 619712
• Length: 564
• Species: Rattus norvegicus
• Alignment Length: 560
• Identity: 197/560 - (35%)
• Similarity: 293/560 - (52%)
• Gaps: 74/560 - (13%)

  Fly     4 LEAVLADVSYLMAMEK--SKCTPAARASK---KLNLPDPSVRSVMYKYLEKEG-----ELNFHKI 58
            ||.|:|:.:::.|...  ...||::|..|   ||.||..|         :.||     .|.|..:
  Rat     6 LETVVANSAFIAARGSFDGSSTPSSRDKKYLAKLRLPPLS---------KCEGLRDSISLEFDNL 61

  Fly    59 FNE-VLGYLLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDERKKMARDI-----------YDN 111
            .:| .:|..||:.|.:.| |..:..|:.::.|:.:: |...|.|.:.|:.|           :.|
  Rat    62 CSEQPIGKRLFQQFLKTD-ERHVPALELWKDIEDYD-TADDDLRPQKAQAILAEYLDPQGTLFCN 124

  Fly   112 FIMEEMLSHTYEYSKHAVASVQKYLLKNEVPV----DLFEPYLEEIFTQLKGKPFKKFLESDKFT 172
            |:.:.|           ||.|:      |.|.    .||:|.|:.....|...||:::|.|..|.
  Rat   125 FLDQGM-----------VARVK------EGPTGSQDGLFQPLLQATLEHLSQGPFQEYLGSLYFL 172

  Fly   173 RFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLAL 237
            ||.|||.||.. .:..:.|...|::|:||||||..|:...||||||.|.|:|||:|.::|...|:
  Rat   173 RFLQWKWLEAQ-PIGEDWFLDFRVLGKGGFGEVSACQMKATGKMYACKKLNKKRLKKRKGYQGAI 236

  Fly   238 NERNMLQAVSTGIDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHL----SQHGIFSEDEMKFY 298
            .|:.:|..|.:    .|||.:.|||.|...||.::.:|||||:.||:    .::..|.|....:|
  Rat   237 VEKRILAKVHS----RFIVSLAYAFETKTDLCLVMTIMNGGDVRYHIYNVDEENPGFPEPRAIYY 297

  Fly   299 AAEVILGLEHMHKRCIVYRDLKPANILLDENGHIRISDLGLACDF----SKKKPHASVGTHGYMA 359
            .|::|.||||:|:|.||||||||.|:|||.:|:|||||||||.:.    :|.|.:|  ||.|:||
  Rat   298 TAQIISGLEHLHQRRIVYRDLKPENVLLDNDGNIRISDLGLAVELKEGQNKTKGYA--GTPGFMA 360

  Fly   360 PEVLSKGTSYDSCADWFSFGCMLYKLLKGHSPFRQHKTK-DKLEIDKMTLTMNVELPESFSLELK 423
            ||:| :|..||...|:|:.|..||:::....|||....| :..|:.:..::..|:.||.||...|
  Rat   361 PELL-RGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRIISEPVKYPEKFSQASK 424

  Fly   424 NLLEMLLQRDVSKRLGCMGNGADEVKMHNFFCGIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGS 488
            :..|.||::|..||||......|.::.:..|..|.|.|:......||.:|....|.|.:..|:|:
  Rat   425 DFCEQLLEKDPEKRLGFRDGTCDALRANVLFKDISWRQLEAGMLIPPFIPDSRTVYAKNIQDVGA 489

  Fly   489 FDEEDTKGIKLNDADQDLYKMF-SLTISERWQQEVSETVF 527
            |  ...||:..:.||.:.::.| |...|..||:|:.||.|
  Rat   490 F--STVKGVVFDKADTEFFQEFASGNCSIPWQEEMIETGF 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	49/179 (27%)
		PKc_like	185..531	CDD:304357	140/353 (40%)
		Pkinase	191..454	CDD:278497	115/271 (42%)
		PH_GRK2_subgroup	552..675	CDD:269946
		PH	559..657	CDD:278594
Grk1	NP_112358.1	N-terminal	1..189		57/211 (27%)
		Interaction with RCVRN. /evidence=ECO:0000250|UniProtKB:P28327	1..15		4/8 (50%)
		RGS	42..179	CDD:383028	42/164 (26%)
		STKc_GRK1	188..475	CDD:270759	121/293 (41%)
		C-terminal	456..564		24/74 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820