DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Gprk1 and RPS6KB2

DIOPT Version :10

Sequence 1:NP_001036438.1 Gene:Gprk1 / 3355013 FlyBaseID:FBgn0260798 Length:700 Species:Drosophila melanogaster
Sequence 2:NP_003943.2 Gene:RPS6KB2 / 6199 HGNCID:10437 Length:482 Species:Homo sapiens


Alignment Length:372 Identity:126/372 - (33%)
Similarity:194/372 - (52%) Gaps:43/372 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   191 FSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGEMLALN-ERNMLQAVSTGID 251
            |.:.|::|:||:|:|:..||   .:.||:||||.|.|.:|.....:..... |||:|::|..   
Human    67 FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKH--- 128

  Fly   252 CPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGIFSEDEMKFYAAEVILGLEHMHKRCIVY 316
             ||||.:.|||.|..||..||:.::||:|..||.:.|||.||...||.||:.|.|.|:|.:.|:|
Human   129 -PFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIY 192

  Fly   317 RDLKPANILLDENGHIRISDLGLACDFSKKK---PHASVGTHGYMAPEVLSKGTSYDSCADWFSF 378
            |||||.||:|...|||:::|.|| |..|..:   .|...||..|||||:|.: :.::...||:|.
Human   193 RDLKPENIMLSSQGHIKLTDFGL-CKESIHEGAVTHTFCGTIEYMAPEILVR-SGHNRAVDWWSL 255

  Fly   379 GCMLYKLLKGHSPF---RQHKTKDKLEIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSKRLGC 440
            |.::|.:|.|..||   .:.||.||:...|:.      ||...:.:.::|::..|:|:.|:|:|.
Human   256 GALMYDMLTGSPPFTAENRKKTMDKIIRGKLA------LPPYLTPDARDLVKKFLKRNPSQRIGG 314

  Fly   441 MGNGADEVKMHNFFCGIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQD 505
            ....|.:|:.|.||..::|..:...:..||..|     ......|:..||...|:...::..|  
Human   315 GPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRP-----CLQSEEDVSQFDTRFTRQTPVDSPD-- 372

  Fly   506 LYKMFSLTISERWQQE------VSETVFDTVN---TETDKLEQKRKL 543
                 ...:||...|.      |:.:|.|::.   :...||...|:|
Human   373 -----DTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRL 414

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gprk1NP_001036438.1 RGS_GRK2_GRK3 30..186 CDD:188701
Protein Kinases, catalytic domain 185..531 CDD:473864 122/355 (34%)
PH_GRK2_subgroup 552..675 CDD:269946
RPS6KB2NP_003943.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
STKc_p70S6K 70..392 CDD:270736 119/345 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 407..482 4/8 (50%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:12529391 471..477
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.