Protein Alignment Gprk1 and GRK1

DIOPT Version :9

• Sequence 1: NP_001036438.1
• Gene: Gprk1 / 3355013
• FlyBaseID: FBgn0260798
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_002920.1
• Gene: GRK1 / 6011
• HGNCID: 10013
• Length: 563
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 189/552 - (34%)
• Similarity: 294/552 - (53%)
• Gaps: 49/552 - (8%)

  Fly     4 LEAVLADVSYLMA---MEKSKCTPAARASK---KLNLPDPSVRSVMYKYLEKEGELNFHKI-FNE 61
            ||.|:|:.:::.|   .:.|...| :|..|   ||.||..|    ..:.|.....|.|..: ..:
Human     6 LETVVANSAFIAARGSFDGSSSQP-SRDKKYLAKLKLPPLS----KCESLRDSLSLEFESVCLEQ 65

  Fly    62 VLGYLLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDERKKMARDIYDNFIMEEMLSHTYEYSK 126
            .:|..||:.|.:: :|:.:..|:.::.|:.:: |...|.:.:.|:.|...::..:.........:
Human    66 PIGKKLFQQFLQS-AEKHLPALELWKDIEDYD-TADNDLQPQKAQTILAQYLDPQAKLFCSFLDE 128

  Fly   127 HAVASVQKYLLKNEVPVD----LFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKNLELNIQLT 187
            ..||..:      |.||:    ||:|.|:.....|...||:::|.|..|.||.|||.||..   .
Human   129 GIVAKFK------EGPVEIQDGLFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWKWLEAQ---P 184

  Fly   188 MND--FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGI 250
            |.:  |...|::|:||||||..|:...|||:||.|.|:|||:|.::|...|:.|:.:|..|.:
Human   185 MGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKVHS-- 247

  Fly   251 DCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHL----SQHGIFSEDEMKFYAAEVILGLEHMHK 311
              .|||.:.|||.|...||.::.:|||||:.||:    .::..|.|....||.|::|.||||:|:
Human   248 --RFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQ 310

  Fly   312 RCIVYRDLKPANILLDENGHIRISDLGLACDF----SKKKPHASVGTHGYMAPEVLSKGTSYDSC 372
            |.||||||||.|:|||.:|::||||||||.:.    ||.|.:|  ||.|:||||:| :|..||..
Human   311 RRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYA--GTPGFMAPELL-QGEEYDFS 372

  Fly   373 ADWFSFGCMLYKLLKGHSPFRQHKTK-DKLEIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSK 436
            .|:|:.|..||:::....|||....| :..|:....::..|:.|:.||...|:..|.||::|..|
Human   373 VDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCEALLEKDPEK 437

  Fly   437 RLGCMGNGADEVKMHNFFCGIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLND 501
            |||......|:::.|..|..::|.|:......||.:|....|.|.|..|:|:|  ...||:..:.
Human   438 RLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVYAKDIQDVGAF--STVKGVAFDK 500

  Fly   502 ADQDLYKMFSL-TISERWQQEVSET-VFDTVN 531
            .|.:.::.|:. .....||:|:.|| :|..:|
Human   501 TDTEFFQEFATGNCPIPWQEEMIETGIFGELN 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	42/163 (26%)
		PKc_like	185..531	CDD:304357	138/358 (39%)
		Pkinase	191..454	CDD:278497	115/271 (42%)
		PH_GRK2_subgroup	552..675	CDD:269946
		PH	559..657	CDD:278594
GRK1	NP_002920.1	N-terminal	1..189		51/198 (26%)
		Interaction with RCVRN. /evidence=ECO:0000250|UniProtKB:P28327	1..15		4/8 (50%)
		RGS	42..179	CDD:383028	35/148 (24%)
		STKc_GRK1	188..475	CDD:270759	120/293 (41%)
		C-terminal	456..563		22/79 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	539..563

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820