Protein Alignment Gprk1 and Grk5

DIOPT Version :9

• Sequence 1: NP_001036438.1
• Gene: Gprk1 / 3355013
• FlyBaseID: FBgn0260798
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: XP_038944728.1
• Gene: Grk5 / 59075
• RGDID: 61985
• Length: 640
• Species: Rattus norvegicus
• Alignment Length: 630
• Identity: 216/630 - (34%)
• Similarity: 315/630 - (50%)
• Gaps: 106/630 - (16%)

  Fly     3 DLEAVLADVSYLMAMEK-----SKCTPAAR---------------ASKK----LNLPDPSVRSVM 43
            :||.::|:...|.|.|.     |..||.:.               .|||    |..|..|....:
  Rat     2 ELENIVANTVLLKAREDYCQTCSSPTPGSNPAGKRHVGGGGKRKGKSKKWKEILKFPHISQCEDL 66

  Fly    44 YKYLEKEGELNFHKIFN-EVLGYLLFKDFCENDSEEPIQQ--LKFFEQIKLFEKTECYDER-KKM 104
            .:.::::    ::.:.: :.:|.|||:.|||.   .|..:  ::|.:.:..:|.|.  ||. ...
  Rat    67 RRTIDRD----YYSLCDKQPIGRLLFRQFCET---RPGLECYIQFLDLVAEYEITP--DENLGAK 122

  Fly   105 ARDIYDNFIMEEMLSHTYEY---------------SKHAVAS--------------VQKYLLKNE 140
            .::|...::..:..|:....               ..:||||              .:|.||::.
  Rat   123 GKEIMTKYLSPKFWSYKITIVPRFYVGPGDLNSSPDAYAVASPVFIAQVGQDLVSQTEKKLLQSP 187

  Fly   141 VPVDLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEV 205
            .. :||....:.:...|||.||.::|:|..|.||.|||.||.. .:|.|.|..:|::|:||||||
  Rat   188 CK-ELFSACAQSVHDYLKGDPFHEYLDSMYFDRFLQWKWLERQ-PVTKNTFRQYRVLGKGGFGEV 250

  Fly   206 YGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTYAFHTPDKLCF 270
            ..|:...||||||.|.|:|||||.::||.:||||:.:|:.|::    .|:|.:.||:.|.|.||.
  Rat   251 CACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS----QFVVNLAYAYETKDALCL 311

  Fly   271 ILDLMNGGDLHYHLSQHGI--FSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANILLDENGHIR 333
            :|.:||||||.:|:...|.  |.|:...|||||::.|||.:|:...|||||||.|||||:.||||
  Rat   312 VLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIR 376

  Fly   334 ISDLGLACDFSKKKPHAS-----VGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYKLLKGHSPFR 393
            |||||||.    |.|...     |||.||||||||: ...|....|::..||::|::::|.||||
  Rat   377 ISDLGLAV----KIPEGDLIRGRVGTVGYMAPEVLN-NQRYGLSPDYWGLGCLIYEMIEGQSPFR 436

  Fly   394 QHKTKDKL-EIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSKRLGCMGNGADEVKMHNFFCGI 457
            ..|.|.|. |:|:..|.........||.|.|::..|||.:|..:||||...||.|||.|.||..:
  Rat   437 GRKEKVKREEVDRRVLETEEVYSPKFSEEAKSICNMLLTKDSKQRLGCQEEGAAEVKRHPFFRNM 501

  Fly   458 DWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQDLYKMFSL-TISERWQQE 521
            ::.::......||.||....|...|..||..|  ...||:.|:..|.|.|..||. ::...||.|
  Rat   502 NFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQF--STVKGVNLDHTDDDFYSKFSTGSVPIPWQNE 564

  Fly   522 VSET-------VFDTVNTETDKLEQKR-----------KLKQKQH 548
            :.||       ||....|.:..|.:.:           :|.::||
  Rat   565 MIETECFKELNVFGPNGTLSPDLNRSQPPEPPKKGLFHRLFRRQH 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	44/192 (23%)
		PKc_like	185..531	CDD:304357	157/361 (43%)
		Pkinase	191..454	CDD:278497	129/270 (48%)
		PH_GRK2_subgroup	552..675	CDD:269946
		PH	559..657	CDD:278594
Grk5	XP_038944728.1	RGS	74..225	CDD:413378	36/156 (23%)
		STKc_GRK5	233..545	CDD:270780	144/322 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348841
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750