DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gprk1 and grk3

DIOPT Version :9

Sequence 1:	NP_001036438.1	Gene:	Gprk1 / 3355013	FlyBaseID:	FBgn0260798	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_009303964.1	Gene:	grk3 / 569403	ZFINID:	ZDB-GENE-030616-382	Length:	701	Species:	Danio rerio

Alignment Length:	692	Identity:	461/692 - (66%)
Similarity:	544/692 - (78%)	Gaps:	24/692 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADLEAVLADVSYLMAMEKSKCTPAARASKKLNLPDPSVRSVMYKYLEKEGELNFHKIFNEVLGY 65
            |||||||||||||||||||||.|||||||||:.||:||:||||.||||:..||.|.||||:.:|:
Zfish     1 MADLEAVLADVSYLMAMEKSKSTPAARASKKIILPEPSIRSVMQKYLEERDELAFDKIFNQKIGF 65

  Fly    66 LLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDERKKMARDIYDNFIMEEMLSHTYEYSKHAVA 130
            |||||||.|:.:|.:.||||:|:||.:||.:..:||...:|.|||.:||:|:||.::.:||.||.
Zfish    66 LLFKDFCMNEIDEAVPQLKFYEEIKEYEKLDSEEERLTRSRQIYDVYIMKELLSCSHPFSKKAVD 130

  Fly   131 SVQKYLLKNEVPVDLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKNLELNIQLTMNDFSVHR 195
            .||.:|.|.:||.:||:||:.||...|:|..|:||:|||||||||||||:||||.||||||||||
Zfish   131 HVQTHLAKKQVPPNLFQPYIVEICDSLRGNIFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHR 195

  Fly   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTY 260
            ||||||||||||||||||||||||||||||||||||||.||||||.||..|||| ||||||||||
Zfish   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG-DCPFIVCMTY 259

  Fly   261 AFHTPDKLCFILDLMNGGDLHYHLSQHGIFSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANIL 325
            ||||||||||||||||||||||||||||:|||.:|:|||||:||||||||.|.:|||||||||||
Zfish   260 AFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKDMRFYAAEIILGLEHMHNRFVVYRDLKPANIL 324

  Fly   326 LDENGHIRISDLGLACDFSKKKPHASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYKLLKGHS 390
            |||:||:|||||||||||||||||||||||||||||||.|||:|||.|||||.||||:|||:|||
Zfish   325 LDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHS 389

  Fly   391 PFRQHKTKDKLEIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSKRLGCMGNGADEVKMHNFFC 455
            ||||||||||.|||:||||||||||:||:.|||:|||.||||||:|||||:|.||.|||.|.||.
Zfish   390 PFRQHKTKDKHEIDRMTLTMNVELPDSFTPELKSLLEGLLQRDVAKRLGCLGRGASEVKEHVFFK 454

  Fly   456 GIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQDLYKMFSLTISERWQQ 520
            ||||.|||:|||.|||:|||||||||||||||||||||||||||.|:||:|||.|.|.|||||||
Zfish   455 GIDWQQVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYKNFPLVISERWQQ 519

  Fly   521 EVSETVFDTVNTETDKLEQKRKLKQKQ--HFDADEKESDCILHGYIKKLGGSFASLWQTKYAKLY 583
            ||:|||::.||::|||.|.:::.|.||  |.:......|||:|||:.|||..|.:.||.:|..|:
Zfish   520 EVAETVYEAVNSDTDKNEARKRAKNKQQGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLF 584

  Fly   584 PNRLELHSESGNN------------KPELIFMDQVEDISSDFILHKNENCIQIRINDGTRDGRII 636
            |||:|...|..:.            |..|:.|:.:..:....|  |::.||.:|:..|.   :.:
Zfish   585 PNRVEWRGEGESRECWTKTLKKHKFKQNLLTMEHIVTVEETQI--KDKKCILLRVKGGK---QFV 644

  Fly   637 LTNSDEIGLKEWSSSLRSAHKISQDLLGSMAKKAGKIYGSER 678
            |....:....:|...|..|...:|.||    ::|.|:.|..|
Zfish   645 LQCESDPEFVQWKKELTEAFTEAQKLL----RRAPKVIGKGR 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	89/155 (57%)
		PKc_like	185..531	CDD:304357	295/345 (86%)
		Pkinase	191..454	CDD:278497	228/262 (87%)
		PH_GRK2_subgroup	552..675	CDD:269946	37/134 (28%)
		PH	559..657	CDD:278594	30/109 (28%)
grk3	XP_009303964.1	RGS_GRK2_GRK3	30..186	CDD:188701	89/155 (57%)
		PKc_like	185..530	CDD:304357	295/345 (86%)
		Pkinase	191..453	CDD:278497	228/262 (87%)
		PH_GRK2_subgroup	553..683	CDD:269946	39/139 (28%)
		PH	560..663	CDD:278594	29/107 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	478	1.000	Domainoid score	I401
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21072
Inparanoid	1	1.050	917	1.000	Inparanoid score	I352
OMA	1	1.010	-	-		QHG45729
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	1	1.000	-	-		FOG0004399
OrthoInspector	1	1.000	-	-		oto41081
orthoMCL	1	0.900	-	-		OOG6_106250
Panther	1	1.100	-	-	LDO	PTHR24355
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3114
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980