Protein Alignment Gprk1 and grk1a

DIOPT Version :9

• Sequence 1: NP_001036438.1
• Gene: Gprk1 / 3355013
• FlyBaseID: FBgn0260798
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001029353.2
• Gene: grk1a / 564152
• ZFINID: ZDB-GENE-050823-1
• Length: 563
• Species: Danio rerio
• Alignment Length: 575
• Identity: 202/575 - (35%)
• Similarity: 303/575 - (52%)
• Gaps: 40/575 - (6%)

  Fly     4 LEAVLADVSYLMAMEK--SKCTPAARASK----KLNLPDPSVRSVMYKYLEKEGELNFHKI-FNE 61
            |..|:|:.:|:.|...  ....||:...|    ||.||..:|...:.:.|    :|.|..| ..:
Zfish     6 LTTVVANSAYISARGSFDGTANPASNRDKKYHSKLKLPHITVCEDLRETL----DLQFRSICVEQ 66

  Fly    62 VLGYLLFKDFCE--NDSEEPIQQLKFFEQIKLFEKTECYDERKKMARDIYDNFIMEEMLSHTYEY 124
            .:|..||:::.|  |:.:.|   .:.:..::.::..|..|..:|.|: |...: ||....|...:
Zfish    67 PIGKRLFQEYLETANEYKGP---CRLWRDVEEYDTAEDKDRTQKAAK-ILQRY-MEPSAKHFCPF 126

  Fly   125 -SKHAVASVQKYLLKNEVPVDLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKNLELNIQLTM 188
             .::.:..|::  ...|...|||...|..:|..||..||..:||:..|.||.|||.||:  |...
Zfish   127 LPENGITKVKE--RHQEAADDLFVEILACVFDFLKEVPFTFYLETMYFKRFLQWKWLEM--QPVA 187

  Fly   189 ND-FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDC 252
            .| |...|::|:||||||..|:...|||:||.|.|:|||:|.::|...|:.|:.:|..|.:
Zfish   188 EDWFLDFRVLGKGGFGEVSACQMRATGKLYACKKLNKKRLKKRKGYEGAMVEKRILARVHS---- 248

  Fly   253 PFIVCMTYAFHTPDKLCFILDLMNGGDLHYHL----SQHGIFSEDEMKFYAAEVILGLEHMHKRC 313
            .|||.:.|||.|..:||.::.:||||||.||:    ..:..|||....:|||::|.||||:|::.
Zfish   249 RFIVSLAYAFQTKTELCLVMTIMNGGDLRYHIYNVDENNPGFSEPRACYYAAQIIQGLEHLHQKK 313

  Fly   314 IVYRDLKPANILLDENGHIRISDLGLACDFS--KKKPHASVGTHGYMAPEVLSKGTSYDSCADWF 376
            |:||||||.|:|||..|::||||||||.:.:  ::|.....||.|:||||:| ||..||...|:|
Zfish   314 IIYRDLKPENVLLDNEGNVRISDLGLAVELADGQEKTKGYAGTPGFMAPELL-KGEEYDYSVDYF 377

  Fly   377 SFGCMLYKLLKGHSPFRQHKTK-DKLEIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSKRLGC 440
            :.|..||:.:....|||....| :..|:.|..|...|...|.||...|::.|.||.::|.||||.
Zfish   378 TLGVTLYEFIAAKGPFRTRGEKVENKEVKKRILNDPVTYSEKFSENAKSICEGLLAKEVDKRLGF 442

  Fly   441 MGNGADEVKMHNFFCGIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQD 505
            .....||::.|.||..::|.::......||.||....|.|.|..|:|:|  ...||:.|.|.|:.
Zfish   443 KNGTCDEIRTHPFFSQLNWRKLDAGILPPPFVPDSKTVYAKDLDDVGAF--STVKGVCLEDDDKC 505

  Fly   506 LYKMF-SLTISERWQQEVSET-VFDTVNTETDKLEQKRKLKQKQHFDADEKESDC 558
            .:..| |..||..||:|:.|| ::..:|...........|:::...:...|.|.|
Zfish   506 FFDEFASGNISIPWQEEMIETGIYGELNVWGPGGAVPNDLRRESILEQPPKSSTC 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	45/163 (28%)
		PKc_like	185..531	CDD:304357	145/355 (41%)
		Pkinase	191..454	CDD:278497	116/269 (43%)
		PH_GRK2_subgroup	552..675	CDD:269946	3/7 (43%)
		PH	559..657	CDD:278594	202/575 (35%)
grk1a	NP_001029353.2	RGS	43..180	CDD:295367	38/147 (26%)
		STKc_GRK1	189..476	CDD:270759	123/291 (42%)
		S_TKc	195..456	CDD:214567	115/265 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820