Protein Alignment Gprk1 and grk5

DIOPT Version :9

• Sequence 1: NP_001036438.1
• Gene: Gprk1 / 3355013
• FlyBaseID: FBgn0260798
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001166974.1
• Gene: grk5 / 560806
• ZFINID: ZDB-GENE-091204-274
• Length: 588
• Species: Danio rerio
• Alignment Length: 565
• Identity: 198/565 - (35%)
• Similarity: 307/565 - (54%)
• Gaps: 50/565 - (8%)

  Fly     3 DLEAVLADVSYLMAMEKSKCTPAARASK-KLNLPDPSVRSVMYKYLEKEGELNFHKI-FNEVLGY 65
            ::|.:.|:.:.|.|.:........|:.| |..|..|.:...  |.||...|.:::.: .|:.:|.
Zfish     2 EIETMAANCALLKARDAGNAYRKGRSRKWKEILHFPHINQC--KELENSIERDYYSLCVNQPIGK 64

  Fly    66 LLFKDFCENDSEEPIQQL-KFFEQIKLFEKTECYDERKKMARDIYDNFIMEEMLSHTYEYSKHAV 129
            .|||.||.  :|..:|.| ...|::..:|.|.  |:.||.:||         .|.:.::.|:.::
Zfish    65 QLFKLFCA--TEPKLQHLIDLLEEMAKYEVTT--DDLKKTSRD---------KLINKFKTSQSSM 116

  Fly   130 A--SVQKYLLKNEVPVDLF----EPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKNLELNIQLTM 188
            .  .|.|.:....:.::.|    ...|.|   .|.|.||.::..|..|.||.|||.:|.. .:|.
Zfish   117 VREMVHKEMQNGNLNMENFISSCHSALHE---YLSGAPFSEYQNSMYFDRFLQWKMVERR-PVTQ 177

  Fly   189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCP 253
            ::|..:||:|:||||||..|:...:|||||.|.|.|||:|.:.||.:.|.|:.:|:.|::    .
Zfish   178 DNFREYRILGKGGFGEVCACQSRASGKMYACKKLVKKRVKRQGGEKMVLKEKQILERVNS----R 238

  Fly   254 FIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHG--IFSEDEMKFYAAEVILGLEHMHKRCIVY 316
            |:|.:.|.:.|.|.||.:|.:|:||||.:|:.:.|  ...::.::||||||:.||:|:||..:||
Zfish   239 FVVSLAYTYETKDSLCLVLTVMDGGDLGFHIYKMGNQKLDKNRVQFYAAEVLCGLDHLHKHNVVY 303

  Fly   317 RDLKPANILLDENGHIRISDLGLACDFSKKK-PHASVGTHGYMAPEVLSKGTSYDSCADWFSFGC 380
            |||||.|||||..|||||||||||....:.| ....|||.|||||||:: ||||....||:..||
Zfish   304 RDLKPENILLDYEGHIRISDLGLAEILPENKLVKGRVGTAGYMAPEVVA-GTSYGVSVDWWGLGC 367

  Fly   381 MLYKLLKGHSPFRQHKTK-DKLEIDKMTLTMNVEL-PESFSLELKNLLEMLLQRDVSKRLGC-MG 442
            ::|::.....|||.||.: .|.::::..|. .||| .:.|..|.:|:.:.||.::..:|||| .|
Zfish   368 LIYEMTAKKPPFRNHKEQISKKDLEQRILE-KVELYDKMFDEETQNICQKLLAKNPKERLGCRSG 431

  Fly   443 NGADEVKMHNFFCGIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQDLY 507
            .||:.:|.|.||..|::..:......||.:|....:...|..||..|  ...||:.|::||:..|
Zfish   432 QGAEVIKSHQFFKNINFTLLEAGMMQPPFIPDPRAIYCDDVSDIDQF--AAVKGVTLDEADEAFY 494

  Fly   508 KMFSL-TISERWQQEVSET-------VFDTVNTETDKLEQKRKLK 544
            ..|:. :::..||.|:.||       ||....|.:..|::..:::
Zfish   495 AEFNTGSVTVPWQTEMIETECFKDLNVFGPHGTRSQDLDRSEQIQ 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	45/164 (27%)
		PKc_like	185..531	CDD:304357	146/359 (41%)
		Pkinase	191..454	CDD:278497	121/268 (45%)
		PH_GRK2_subgroup	552..675	CDD:269946
		PH	559..657	CDD:278594
grk5	NP_001166974.1	RGS	35..173	CDD:295367	42/155 (27%)
		PKc_like	180..464	CDD:304357	127/289 (44%)
		S_TKc	180..443	CDD:214567	121/268 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820