Protein Alignment Gprk1 and grk4

DIOPT Version :10

• Sequence 1: NP_001036438.1
• Gene: Gprk1 / 3355013
• FlyBaseID: FBgn0260798
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001349548.1
• Gene: grk4 / 560761
• ZFINID: ZDB-GENE-060929-1198
• Length: 579
• Species: Danio rerio
• Alignment Length: 540
• Identity: 197/540 - (36%)
• Similarity: 302/540 - (55%)
• Gaps: 27/540 - (5%)

  Fly     3 DLEAVLADVSYLMAMEKSKCTPAARASK---KLNLPDPSVRSVMYKYLEKEGELNFHKIFNEVLG 64
            ::|.::|:...|.|.|........|:.|   .|.||..|....:.:.:|::......|   :.:|
Zfish     2 EIENIVANTVLLKAREGGGGKRNGRSKKWKEMLKLPHISQCEELRRTIERDYTSLCEK---QPIG 63

  Fly    65 YLLFKDFCENDSEEPIQQ-LKFFEQIKLFEKTECYDERKKMA-RDIYDNFIMEEMLSHTYEYSKH 127
            ..||:.||  |::..::: ::|.:.:.:::...  ||:::.| .:|.|.:......:|..|.::.
Zfish    64 RQLFRQFC--DTQPKLRRCIEFLDSVAMYQVAP--DEKRRDAGLNILDTYFNNGSAAHLPEMAQD 124

  Fly   128 AVASVQKYLLKNEVPVDLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKNLELNIQLTMNDFS 192
            .|...::.|.::... :||:.....:...|.|.||..:.|:..|:||.|||.||.. .:|.|.|.
Zfish   125 VVGECRQKLEQSPCK-ELFQECTRIVREYLSGAPFSAYQETMYFSRFLQWKWLERQ-PVTKNTFR 187

  Fly   193 VHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVC 257
            .:|::|:||||||..|:...||||||.|.|:|||:|.::||.:||||:.:|:.|::.    |:|.
Zfish   188 HYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRVKKRKGEAMALNEKRILEKVNSS----FVVS 248

  Fly   258 MTYAFHTPDKLCFILDLMNGGDLHYHLSQHGIFSEDEMK--FYAAEVILGLEHMHKRCIVYRDLK 320
            :.||:.|.|.||.:|.:||||||.:|:...|....||.:  |||||:..|||.:|:..|||||||
Zfish   249 LAYAYETKDALCLVLTIMNGGDLKFHIYNMGNSGFDEQRAIFYAAEICCGLEDLHRERIVYRDLK 313

  Fly   321 PANILLDENGHIRISDLGLACDFSKKKP-HASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYK 384
            |.|||||:.|||||||||||....:.:. ...|||.|||||||: :..||....||:..||::|:
Zfish   314 PENILLDDRGHIRISDLGLAVQIPEGETIRGRVGTVGYMAPEVI-QNESYTFSPDWWGLGCLIYE 377

  Fly   385 LLKGHSPFRQHKTKDKL-EIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSKRLGCMGNGADEV 448
            :::|.||||:.|.:.|. |:|:.......|..|.||.:.|::...||.:|..:||||.|:||.||
Zfish   378 MIQGQSPFRRRKERVKREEVDRRVCEDQEEYTEKFSEDAKDICRQLLCKDPKERLGCRGSGAAEV 442

  Fly   449 KMHNFFCGIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQDLY-KMFSL 512
            |:|..|..|::.::......||..|....|...|..||..|  ...||:.|:..|.|.| |..:.
Zfish   443 KLHPIFRNINFKRLEANMLDPPFCPDPRAVYCKDVLDIEQF--STVKGVNLDPTDDDFYHKFVTG 505

  Fly   513 TISERWQQEVSE-TVFDTVN 531
            ::|..||.|:.| ..|..:|
Zfish   506 SVSIPWQNEMIEMECFKEIN 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	38/160 (24%)
		Protein Kinases, catalytic domain	185..531	CDD:473864	152/351 (43%)
		PH_GRK2_subgroup	552..675	CDD:269946
grk4	NP_001349548.1	RGS_GRK4	52..183	CDD:188704	32/139 (23%)
		Protein Kinases, catalytic domain	185..469	CDD:473864	132/288 (46%)