DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gprk1 and grk4

DIOPT Version :9

Sequence 1:	NP_001036438.1	Gene:	Gprk1 / 3355013	FlyBaseID:	FBgn0260798	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001349548.1	Gene:	grk4 / 560761	ZFINID:	ZDB-GENE-060929-1198	Length:	579	Species:	Danio rerio

Alignment Length:	540	Identity:	197/540 - (36%)
Similarity:	302/540 - (55%)	Gaps:	27/540 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DLEAVLADVSYLMAMEKSKCTPAARASK---KLNLPDPSVRSVMYKYLEKEGELNFHKIFNEVLG 64
            ::|.::|:...|.|.|........|:.|   .|.||..|....:.:.:|::......|   :.:|
Zfish     2 EIENIVANTVLLKAREGGGGKRNGRSKKWKEMLKLPHISQCEELRRTIERDYTSLCEK---QPIG 63

  Fly    65 YLLFKDFCENDSEEPIQQ-LKFFEQIKLFEKTECYDERKKMA-RDIYDNFIMEEMLSHTYEYSKH 127
            ..||:.||  |::..::: ::|.:.:.:::...  ||:::.| .:|.|.:......:|..|.::.
Zfish    64 RQLFRQFC--DTQPKLRRCIEFLDSVAMYQVAP--DEKRRDAGLNILDTYFNNGSAAHLPEMAQD 124

  Fly   128 AVASVQKYLLKNEVPVDLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKNLELNIQLTMNDFS 192
            .|...::.|.::... :||:.....:...|.|.||..:.|:..|:||.|||.||.. .:|.|.|.
Zfish   125 VVGECRQKLEQSPCK-ELFQECTRIVREYLSGAPFSAYQETMYFSRFLQWKWLERQ-PVTKNTFR 187

  Fly   193 VHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVC 257
            .:|::|:||||||..|:...||||||.|.|:|||:|.::||.:||||:.:|:.|::.    |:|.
Zfish   188 HYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRVKKRKGEAMALNEKRILEKVNSS----FVVS 248

  Fly   258 MTYAFHTPDKLCFILDLMNGGDLHYHLSQHGIFSEDEMK--FYAAEVILGLEHMHKRCIVYRDLK 320
            :.||:.|.|.||.:|.:||||||.:|:...|....||.:  |||||:..|||.:|:..|||||||
Zfish   249 LAYAYETKDALCLVLTIMNGGDLKFHIYNMGNSGFDEQRAIFYAAEICCGLEDLHRERIVYRDLK 313

  Fly   321 PANILLDENGHIRISDLGLACDFSKKKP-HASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYK 384
            |.|||||:.|||||||||||....:.:. ...|||.|||||||: :..||....||:..||::|:
Zfish   314 PENILLDDRGHIRISDLGLAVQIPEGETIRGRVGTVGYMAPEVI-QNESYTFSPDWWGLGCLIYE 377

  Fly   385 LLKGHSPFRQHKTKDKL-EIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSKRLGCMGNGADEV 448
            :::|.||||:.|.:.|. |:|:.......|..|.||.:.|::...||.:|..:||||.|:||.||
Zfish   378 MIQGQSPFRRRKERVKREEVDRRVCEDQEEYTEKFSEDAKDICRQLLCKDPKERLGCRGSGAAEV 442

  Fly   449 KMHNFFCGIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQDLY-KMFSL 512
            |:|..|..|::.::......||..|....|...|..||..|  ...||:.|:..|.|.| |..:.
Zfish   443 KLHPIFRNINFKRLEANMLDPPFCPDPRAVYCKDVLDIEQF--STVKGVNLDPTDDDFYHKFVTG 505

  Fly   513 TISERWQQEVSE-TVFDTVN 531
            ::|..||.|:.| ..|..:|
Zfish   506 SVSIPWQNEMIEMECFKEIN 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	38/160 (24%)
		PKc_like	185..531	CDD:304357	152/351 (43%)
		Pkinase	191..454	CDD:278497	127/266 (48%)
		PH_GRK2_subgroup	552..675	CDD:269946
		PH	559..657	CDD:278594
grk4	NP_001349548.1	RGS_GRK4	52..183	CDD:188704	32/139 (23%)
grk4	NP_001349548.1	PKc_like	185..469	CDD:328722	132/288 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820