DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gprk1 and Gprk2

DIOPT Version :9

Sequence 1:	NP_001036438.1	Gene:	Gprk1 / 3355013	FlyBaseID:	FBgn0260798	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster

Alignment Length:	713	Identity:	216/713 - (30%)
Similarity:	315/713 - (44%)	Gaps:	197/713 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DLEAVLADVSYLMAME--------KS----KCTPAARASKKLNLPDPSVRSVMYKYLEKEGELNF 55
            :||.::|:..||.|.|        ||    |.......|:.:||.|.  ..:.|.|:
  Fly     2 ELENIVANTVYLKAREGGSDSNKGKSKKWRKILQFPHISQCINLKDK--LDISYGYV-------- 56

  Fly    56 HKIFNEVLGYLLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDERKKMARDIYDNFI------- 113
              |..:.:|..||:.||||......:.:.|.:::..:| .|....|..:..||...|:
  Fly    57 --IDQQPIGRELFRLFCENKRPVYFRYITFLDEVVKYE-IEYISNRIFIGHDIGRRFLDVEAQLE 118

  Fly   114 --------------MEEML--------SHTYE-------------------YSKHA--------- 128
                          .||:|        :.|.|                   .|:|:
  Fly   119 LRNGSGGDALDAETQEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLD 183

  Fly   129 ----------------------------------------------------------------- 128

  Fly   184 TRNHNGDDATGNGSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDD 248

  Fly   129 -VASVQKYLLKNEVPVDLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKNLELNIQLTMNDFS 192
             :|.|:..|  |....|:|...:..:...|.|:||::|..|..|.|:.|||.||.. .:|...|.
  Fly   249 LIAQVRNKL--NSGGKDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQ-PITYKTFR 310

  Fly   193 VHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVC 257
            ::|::|:||||||..|:...||||||.|.|:|||||.::||.:.|.|:.:||.:::    ||:|.
  Fly   311 MYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINS----PFVVN 371

  Fly   258 MTYAFHTPDKLCFILDLMNGGDLHYHLSQHG---IFSEDEMKFYAAEVILGLEHMHKRCIVYRDL 319
            :.||:.|.|.||.:|.:||||||.:|:...|   .|..:..:||||||..||:|:||:.|||||.
  Fly   372 LAYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDC 436

  Fly   320 KPANILLDENGHIRISDLGLACDFSK-KKPHASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLY 383
            ||.|||||::||:||||||||.:..: :.....|||.|||||||:. ...|....|||||||:||
  Fly   437 KPENILLDDHGHVRISDLGLAVEIPEGEMVRGRVGTVGYMAPEVID-NEKYAFSPDWFSFGCLLY 500

  Fly   384 KLLKGHSPFRQHKTKDKL-EIDKMTLTMNVELPESFSL----ELKNLLEMLLQRDVSKRLGCMGN 443
            ::::|.:|||..|.|.|. |:|:..    .|.||.:|.    |.|::.:.||.:.:.:||||...
  Fly   501 EMIEGQAPFRMRKEKVKREEVDRRV----KEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNG 561

  Fly   444 --GADEVKMHNFF--CGIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQ 504
              |..:|..|.||  ..::|.::......||.||....|.|.|..||..|  ...||:.::::|.
  Fly   562 RMGGQDVMAHPFFHSTQLNWRRLEAGMLEPPFVPDPHAVYAKDVLDIEQF--STVKGVNIDESDT 624

  Fly   505 DLYKMFSL-TISERWQQEVSET-VFDTVNT-----------------ETDK---LEQKRKLKQ 545
            :.|..|:. ::|..||.|:.|| .|..:|.                 |.||   ...:||.||
  Fly   625 NFYTKFNTGSVSISWQNEMMETECFRELNVFGPEECPTPDLQINAAPEPDKAGCFPFRRKKKQ 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	46/278 (17%)
		PKc_like	185..531	CDD:304357	151/360 (42%)
		Pkinase	191..454	CDD:278497	125/273 (46%)
		PH_GRK2_subgroup	552..675	CDD:269946
		PH	559..657	CDD:278594
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367	20/88 (23%)
		RGS	<248..305	CDD:295367	19/59 (32%)
		STKc_GRK4_like	308..597	CDD:270756	132/297 (44%)
		S_TKc	309..574	CDD:214567	125/273 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460589
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0986
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24355
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850