Protein Alignment Gprk1 and grk7b

DIOPT Version :9

• Sequence 1: NP_001036438.1
• Gene: Gprk1 / 3355013
• FlyBaseID: FBgn0260798
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001028262.1
• Gene: grk7b / 373871
• ZFINID: ZDB-GENE-030904-3
• Length: 548
• Species: Danio rerio
• Alignment Length: 590
• Identity: 190/590 - (32%)
• Similarity: 296/590 - (50%)
• Gaps: 76/590 - (12%)

  Fly     1 MADLEAVLADVSYLMA-------MEKSKCTPAARASKKLNLPD----PSVRSVMYKYLEKEGELN 54
            |..|:.::|:..||.|       ::|.:|:        |.||.    ..||:.:.|..|...|
Zfish     4 MGGLKNLVANTDYLKAQSLDEKEIKKRRCS--------LGLPHLGNCTDVRASVSKGFEDICE-- 58

  Fly    55 FHKIFNEVLGYLLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDERKKMARDIYDNFIMEEMLS 119
                 .:.:|...|:.|....|.|      :....:|.::..|::..:..|::       |..|:
Zfish    59 -----QQPIGRACFRQFLSVSSPE------YLAAAELLDELNCWNLAEAEAKE-------EARLN 105

  Fly   120 HTYEYSKHAVASVQKYLLKNEVP--VDLFEPYLEEIF-------TQ--LKGKPFKKFLESDKFTR 173
            ...::.|....|...:|.::|..  ..:.|...||:.       ||  |:|:||:::..|..|.|
Zfish   106 IINKFCKADSKSFLAFLTEDEAEKCKAVSEKDFEEVMMGQVKEATQKFLRGQPFEEYQTSLFFDR 170

  Fly   174 FCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALN 238
            |.|||..|.. .:|...|...|.:|:||||||.|.:...||:|||.|.|||||:|.|.||.:||.
Zfish   171 FVQWKKFEKQ-PITDKYFYEFRTLGKGGFGEVCGVQVKTTGQMYACKKLDKKRLKKKSGEKMALL 234

  Fly   239 ERNMLQAVSTGIDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHL---SQHGIFSEDEMKFYAA 300
            |:.:|:.|::    .|||.:.|||.|...||.::.||:||||.||:   .:.||..| .:..|.|
Zfish   235 EKKILEMVNS----LFIVNLAYAFDTKTHLCLVMTLMSGGDLKYHIFHVGEVGIEME-RIIHYTA 294

  Fly   301 EVILGLEHMHKRCIVYRDLKPANILLDENGHIRISDLGLACDF-SKKKPHASVGTHGYMAPEVLS 364
            ::..|:.|:|...|||||:||.|:|||..|..|:||||||.:. :.|......||.||||||:|
Zfish   295 QITSGILHLHSMDIVYRDMKPENVLLDCQGQCRLSDLGLAVELPNGKTTTQKAGTKGYMAPEIL- 358

  Fly   365 KGTSYDSCADWFSFGCMLYKLLKGHSPFRQHKTK-DKLEIDKMTLTMNVELP-ESFSLELKNLLE 427
            |...|.:..||::.||.:|:::.|..|||.||.| .|.|:.:.||...|:.. .:|....|:::.
Zfish   359 KQEPYRTSVDWWALGCSIYEMVAGRVPFRDHKEKVAKEELLRRTLEDEVKFEHRNFDAPSKDIIS 423

  Fly   428 MLLQRDVSKRLGCMGNGADEVKMHNFFCGIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEE 492
            :.|:|::..|||    ..|:.:.|.||..|::.::......||..|....|.|.|..||..|  .
Zfish   424 LFLKRNIEDRLG----SNDDPRKHEFFKSINFPRLEAGLIPPPWEPKANVVYAKDTGDIREF--S 482

  Fly   493 DTKGIKLNDADQDLYKMFSL-TISERWQQEVSET-VFDTVNTETDKLEQKRKLKQKQHFDADEKE 555
            |.||:|.:..|:..:|.||. .:...|||.:.:: :||.: ::.::.|....|:.::    .:|.
Zfish   483 DVKGVKFDANDEKFFKEFSTGAVPIAWQQGMIDSGLFDEL-SDPNRKESAAGLEDEE----QQKS 542

  Fly   556 SDCIL 560
            ..|.|
Zfish   543 KSCTL 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	39/170 (23%)
		PKc_like	185..531	CDD:304357	138/353 (39%)
		Pkinase	191..454	CDD:278497	112/268 (42%)
		PH_GRK2_subgroup	552..675	CDD:269946	3/9 (33%)
		PH	559..657	CDD:278594	1/2 (50%)
grk7b	NP_001028262.1	RGS	37..177	CDD:383028	36/159 (23%)
		PKc_like	184..466	CDD:389743	117/291 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	520..548		6/33 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820