DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Gprk1 and Grk3

DIOPT Version :9

Sequence 1:NP_001036438.1 Gene:Gprk1 / 3355013 FlyBaseID:FBgn0260798 Length:700 Species:Drosophila melanogaster
Sequence 2:NP_796052.2 Gene:Grk3 / 320129 MGIID:87941 Length:688 Species:Mus musculus


Alignment Length:680 Identity:448/680 - (65%)
Similarity:532/680 - (78%) Gaps:13/680 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MADLEAVLADVSYLMAMEKSKCTPAARASKKLNLPDPSVRSVMYKYLEKEGELNFHKIFNEVLGY 65
            |||||||||||||||||||||..||||||||:.||:||:||||.:||.:..|:.|.||||:.:|:
Mouse     1 MADLEAVLADVSYLMAMEKSKTAPAARASKKVVLPEPSIRSVMQRYLAERNEITFDKIFNQKIGF 65

  Fly    66 LLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDERKKMARDIYDNFIMEEMLSHTYEYSKHAVA 130
            |||||||.|:..|.:.|:||:|:||.:||.:..::|.:.:|.:||.:||.|:||.|:::||.||.
Mouse    66 LLFKDFCLNEIGEAVPQVKFYEEIKEYEKLDNEEDRLRRSRQMYDAYIMRELLSSTHQFSKQAVE 130

  Fly   131 SVQKYLLKNEVPVDLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKNLELNIQLTMNDFSVHR 195
            .||.:|.|.:|...||:||:|||...|:|..|:||:|||||||||||||:||||.|:||||||||
Mouse   131 HVQSHLSKKQVTATLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLSMNDFSVHR 195

  Fly   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTY 260
            |||||||||||||||||||||||||||||||:||||||.||||||.||..|||| ||||||||||
Mouse   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRVKMKQGETLALNERIMLSLVSTG-DCPFIVCMTY 259

  Fly   261 AFHTPDKLCFILDLMNGGDLHYHLSQHGIFSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANIL 325
            |||||||||||||||||||:||||||||:|||.||:|||:|:||||||||...:|||||||||||
Mouse   260 AFHTPDKLCFILDLMNGGDMHYHLSQHGVFSEKEMRFYASEIILGLEHMHTCFVVYRDLKPANIL 324

  Fly   326 LDENGHIRISDLGLACDFSKKKPHASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYKLLKGHS 390
            |||.||:|||||||||||||||||||||||||||||||.|||.|||.|||||.||||:|||:|||
Mouse   325 LDEYGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTCYDSSADWFSLGCMLFKLLRGHS 389

  Fly   391 PFRQHKTKDKLEIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSKRLGCMGNGADEVKMHNFFC 455
            ||||||||||.|||:||||:||:||::||.||::|||.|||||||:||||.|.||.|:|.|.||.
Mouse   390 PFRQHKTKDKHEIDRMTLTVNVQLPDAFSPELRSLLEGLLQRDVSQRLGCGGGGARELKEHIFFK 454

  Fly   456 GIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQDLYKMFSLTISERWQQ 520
            ||||..||::||.|||:|||||||||||||||||||||||||||.|.||||||.|.|.|||||||
Mouse   455 GIDWQHVYLRKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQDLYKNFPLVISERWQQ 519

  Fly   521 EVSETVFDTVNTETDKLEQKRKLKQKQHFDADE--KESDCILHGYIKKLGGSFASLWQTKYAKLY 583
            ||.||::|.||.:|||:|.:||.|.||....::  ...|||:|||:.|||..|.:.||.:|..|:
Mouse   520 EVVETIYDAVNADTDKIEARRKAKNKQLGQEEDYAMGKDCIMHGYMLKLGNPFLTQWQRRYFYLF 584

  Fly   584 PNRLELHSESGNNKPELIFMDQVEDISSDFILHKNENCIQIRINDGTRDGRIILTNSDEIGLKEW 648
            |||||...| |.::..|:.|:|:..:....|  |:..||.:||..|.   :.:|....:....:|
Mouse   585 PNRLEWRGE-GESRQSLLTMEQIMSVEETQI--KDRKCILLRIKGGK---QFVLQCESDPEFAQW 643

  Fly   649 SSSLRSAHKISQDLLGSMAKKAGKIYGSER 678
            ...|......:|.||    ::|.|.....|
Mouse   644 LKELTCTFNEAQRLL----RRAPKFLNKPR 669

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gprk1NP_001036438.1 RGS_GRK2_GRK3 30..186 CDD:188701 84/155 (54%)
PKc_like 185..531 CDD:304357 286/345 (83%)
Pkinase 191..454 CDD:278497 221/262 (84%)
PH_GRK2_subgroup 552..675 CDD:269946 39/124 (31%)
PH 559..657 CDD:278594 32/97 (33%)
Grk3NP_796052.2 N-terminal 1..190 113/188 (60%)
RGS_GRK2_GRK3 30..186 CDD:188701 84/155 (54%)
PKc_like 185..530 CDD:304357 286/345 (83%)
Pkinase 191..453 CDD:278497 221/262 (84%)
PH_GRK2_subgroup 553..670 CDD:269946 40/127 (31%)
PH 560..647 CDD:278594 31/92 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 465 1.000 Domainoid score I468
eggNOG 1 0.900 - - E1_KOG0986
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H21072
Inparanoid 1 1.050 915 1.000 Inparanoid score I362
Isobase 1 0.950 - 0 Normalized mean entropy S1090
OMA 1 1.010 - - QHG45729
OrthoDB 1 1.010 - - D1104340at2759
OrthoFinder 1 1.000 - - FOG0004399
OrthoInspector 1 1.000 - - otm42755
orthoMCL 1 0.900 - - OOG6_106250
Panther 1 1.100 - - LDO PTHR24355
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2554
SonicParanoid 1 1.000 - - X3114
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1615.820

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