DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gprk1 and GRK6

DIOPT Version :9

Sequence 1:NP_001036438.1 Gene:Gprk1 / 3355013 FlyBaseID:FBgn0260798 Length:700 Species:Drosophila melanogaster
Sequence 2:NP_002073.2 Gene:GRK6 / 2870 HGNCID:4545 Length:589 Species:Homo sapiens


Alignment Length:554 Identity:213/554 - (38%)
Similarity:300/554 - (54%) Gaps:55/554 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 DLEAVLADVSYLMAME------KSKCTPAARASKK----LNLPDPSVRSVMYKYLEKEGELNFHK 57
            :||.::|:...|.|.|      |.|       |||    |..|..|....:...||::    :|.
Human     2 ELENIVANTVLLKAREGGGGNRKGK-------SKKWRQMLQFPHISQCEELRLSLERD----YHS 55

  Fly    58 IF-NEVLGYLLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDERKKMARDIYDNFIMEEMLSHT 121
            :. .:.:|.|||::||.. ..|..:.:.|.:.:..:|.|. .|:||...|.:..||     ||||
Human    56 LCERQPIGRLLFREFCAT-RPELSRCVAFLDGVAEYEVTP-DDKRKACGRQLTQNF-----LSHT 113

  Fly   122 YEYSKHAVASVQKYLLKN------EVPV-DLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKN 179
               ....:..|.:.|:.|      :.|. |||:.........|...||..:|:|..|.||.|||.
Human   114 ---GPDLIPEVPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKW 175

  Fly   180 LELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQ 244
            ||.. .:|.|.|..:|::|:||||||..|:...||||||.|.|:|||||.::||.:||||:.:|:
Human   176 LERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239

  Fly   245 AVSTGIDCPFIVCMTYAFHTPDKLCFILDLMNGGDLH---YHLSQHGIFSEDEMKFYAAEVILGL 306
            .|::    .|:|.:.||:.|.|.||.:|.|||||||.   ||:.|.| |.|....|||||:..||
Human   240 KVNS----RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG-FPEARAVFYAAEICCGL 299

  Fly   307 EHMHKRCIVYRDLKPANILLDENGHIRISDLGLACDFSKKKP-HASVGTHGYMAPEVLSKGTSYD 370
            |.:|:..||||||||.|||||::|||||||||||....:.:. ...|||.|||||||: |...|.
Human   300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVV-KNERYT 363

  Fly   371 SCADWFSFGCMLYKLLKGHSPFRQHKTKDKL-EIDKMTLTMNVELPESFSLELKNLLEMLLQRDV 434
            ...||::.||:||:::.|.|||:|.|.|.|. |::::...:..|..|.||.:.::|...||.:|.
Human   364 FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDP 428

  Fly   435 SKRLGCMGNGADEVKMHNFFCGIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKL 499
            ::||||.|..|.|||.|..|..:::.::......||..|....:...|..||..|  ...||::|
Human   429 AERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQF--STVKGVEL 491

  Fly   500 NDADQDLYKMFSL-TISERWQQEVSET-VFDTVN 531
            ...|||.|:.|:. ::...||.|:.|| .|..:|
Human   492 EPTDQDFYQKFATGSVPIPWQNEMVETECFQELN 525

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gprk1NP_001036438.1 RGS_GRK2_GRK3 30..186 CDD:188701 48/167 (29%)
PKc_like 185..531 CDD:304357 155/352 (44%)
Pkinase 191..454 CDD:278497 131/267 (49%)
PH_GRK2_subgroup 552..675 CDD:269946
PH 559..657 CDD:278594
GRK6NP_002073.2 N-terminal 1..185 58/204 (28%)
RGS 35..179 CDD:295367 45/157 (29%)
STKc_GRK6 185..469 CDD:270779 135/289 (47%)
S_TKc 186..448 CDD:214567 131/267 (49%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1104340at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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