| Sequence 1: | NP_001036438.1 | Gene: | Gprk1 / 3355013 | FlyBaseID: | FBgn0260798 | Length: | 700 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_005299.1 | Gene: | GRK5 / 2869 | HGNCID: | 4544 | Length: | 590 | Species: | Homo sapiens |
| Alignment Length: | 587 | Identity: | 211/587 - (35%) |
|---|---|---|---|
| Similarity: | 312/587 - (53%) | Gaps: | 70/587 - (11%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 3 DLEAVLADVSYLMAME------KSKCTPAARASKK----LNLPDPSVRSVMYKYLEKEGELNFHK 57
Fly 58 IFN-EVLGYLLFKDFCENDSEEPIQQ--LKFFEQIKLFEKTECYDER-KKMARDIYDNFIMEEML 118
Fly 119 SHTYEYSKHAVASVQKYLLKNEVPVDLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKNLELN 183
Fly 184 IQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVST 248
Fly 249 GIDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGI--FSEDEMKFYAAEVILGLEHMHK 311
Fly 312 RCIVYRDLKPANILLDENGHIRISDLGLACDFSKKKPHAS-----VGTHGYMAPEVLSKGTSYDS 371
Fly 372 CADWFSFGCMLYKLLKGHSPFRQHKTKDKL-EIDKMTLTMNVELPESFSLELKNLLEMLLQRDVS 435
Fly 436 KRLGCMGNGADEVKMHNFFCGIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLN 500
Fly 501 DADQDLYKMFSL-TISERWQQEVSET-------VFDTVNT-----------ETDKLEQKRKLKQK 546
Fly 547 QH 548 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Gprk1 | NP_001036438.1 | RGS_GRK2_GRK3 | 30..186 | CDD:188701 | 38/163 (23%) |
| PKc_like | 185..531 | CDD:304357 | 158/361 (44%) | ||
| Pkinase | 191..454 | CDD:278497 | 129/270 (48%) | ||
| PH_GRK2_subgroup | 552..675 | CDD:269946 | |||
| PH | 559..657 | CDD:278594 | |||
| GRK5 | NP_005299.1 | N-terminal | 1..185 | 48/200 (24%) | |
| Interaction with calmodulin | 20..39 | 7/25 (28%) | |||
| RGS_GRK5 | 53..175 | CDD:188706 | 30/127 (24%) | ||
| STKc_GRK5 | 183..495 | CDD:270780 | 144/322 (45%) | ||
| S_TKc | 186..448 | CDD:214567 | 129/270 (48%) | ||
| Nuclear localization signal. /evidence=ECO:0000269|PubMed:15542828 | 388..395 | 3/6 (50%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 531..590 | 6/29 (21%) | |||
| Sufficient for membrane localization | 546..565 | 4/14 (29%) | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165154961 | |
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG0986 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D1104340at2759 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 4 | 3.750 | |||||