DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gprk1 and GRK4

DIOPT Version :10

Sequence 1:NP_001036438.1 Gene:Gprk1 / 3355013 FlyBaseID:FBgn0260798 Length:700 Species:Drosophila melanogaster
Sequence 2:XP_011511749.1 Gene:GRK4 / 2868 HGNCID:4543 Length:617 Species:Homo sapiens


Alignment Length:591 Identity:206/591 - (34%)
Similarity:303/591 - (51%) Gaps:69/591 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 DLEAVLADVSYLMAMEKSKCTPAARASKK----LNLPDPSVRSVMYKYLEKEGELNFHKIFNEVL 63
            :||.::|:...|.|.:......:.| |||    |.||..|..|.:...:||:......|   :.:
Human     2 ELENIVANSLLLKARQGGYGKKSGR-SKKWKEILTLPPVSQCSELRHSIEKDYSSLCDK---QPI 62

  Fly    64 GYLLFKDFCENDSEEPIQQ-LKFFEQIKLFEKTECYDERKKMARDIYDNFIMEEMLSHTYEYSKH 127
            |..||:.||  |::..::: ::|.:.:..:|..: .::|......|.|.|..:::.:...|....
Human    63 GRRLFRQFC--DTKPTLKRHIEFLDAVAEYEVAD-DEDRSDCGLSILDRFFNDKLAAPLPEIPPD 124

  Fly   128 AVASVQKYLLKNEVPVDLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKNLELNIQLTMNDFS 192
            .|...:..|.:.......||.........|:|:||:::.||..|::|.|||.||.. .:|.|.|.
Human   125 VVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ-PVTKNTFR 188

  Fly   193 VHRIIGRGGFGE---------------------------------------VYGCRKADTGKMYA 218
            .:|::|:|||||                                       |..|:...||||||
Human   189 HYRVLGKGGFGEQSPVGCAVDGSWKKQQPNVDDTEARGPEPEAHDTIFSTFVCACQVRATGKMYA 253

  Fly   219 MKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYH 283
            .|.|.|||||.::||.:||||:.:|:.|.:    .|:|.:.||:.|.|.||.:|.:||||||.:|
Human   254 CKKLQKKRIKKRKGEAMALNEKRILEKVQS----RFVVSLAYAYETKDALCLVLTIMNGGDLKFH 314

  Fly   284 LSQHGI--FSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANILLDENGHIRISDLGLACDFSK- 345
            :...|.  |.|....|||||:..|||.:.:..||||||||.|||||:.|||||||||||.:..: 
Human   315 IYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEG 379

  Fly   346 KKPHASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYKLLKGHSPFRQHKTKDKL-EIDKMTLT 409
            ::....|||.|||||||:: ...|....||:..||::|::::|||||:::|.|.|. |:|:....
Human   380 QRVRGRVGTVGYMAPEVVN-NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKN 443

  Fly   410 MNVELPESFSLELKNLLEMLLQRDVSKRLGCMGNGADEVKMHNFFCGIDWHQVYIQKYTPPLVPP 474
            ...|..|.||.:.|::..|||.::.||||||.|.||..||.|..|..|::.::......||..|.
Human   444 DTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPD 508

  Fly   475 RGEVNAADAFDIGSFDEEDTKGIKLNDADQDLYKMFSL-TISERWQQEVSET-VFDTVNTETDKL 537
            ...|...|..||..|..  .|||.|:.||:|.|..|:. .:|..||.|:.|: .|..:|    |.
Human   509 PHAVYCKDVLDIEQFSV--VKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDIN----KS 567

  Fly   538 EQKRKL 543
            |.:..|
Human   568 ESEEAL 573

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gprk1NP_001036438.1 RGS_GRK2_GRK3 30..186 CDD:188701 40/160 (25%)
Protein Kinases, catalytic domain 185..531 CDD:473864 155/390 (40%)
PH_GRK2_subgroup 552..675 CDD:269946
GRK4XP_011511749.1 RGS 52..184 CDD:470619 31/138 (22%)
STKc_GRK4 186..509 CDD:173720 133/327 (41%)
Blue background indicates that the domain is not in the aligned region.

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