Protein Alignment Gprk1 and Grk6

DIOPT Version :9

• Sequence 1: NP_001036438.1
• Gene: Gprk1 / 3355013
• FlyBaseID: FBgn0260798
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001033107.1
• Gene: Grk6 / 26385
• MGIID: 1347078
• Length: 589
• Species: Mus musculus
• Alignment Length: 555
• Identity: 214/555 - (38%)
• Similarity: 300/555 - (54%)
• Gaps: 57/555 - (10%)

  Fly     3 DLEAVLADVSYLMAME------KSKCTPAARASKK----LNLPDPSVRSVMYKYLEKEGELNFHK 57
            :||.::|:...|.|.|      |.|       |||    |..|..|....:...||::    :|.
Mouse     2 ELENIVANTVLLKAREGGGGNRKGK-------SKKWRQMLQFPHISQCEELRLSLERD----YHS 55

  Fly    58 IF-NEVLGYLLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDE-RKKMARDIYDNFIMEEMLSH 120
            :. .:.:|.|||::||.. ..|..:...|.:.:..:|.|.  || ||...|.:..||     |||
Mouse    56 LCERQPIGRLLFREFCAT-RPELTRCTAFLDGVSEYEVTP--DEKRKACGRRLMQNF-----LSH 112

  Fly   121 TYEYSKHAVASVQKYLLKN------EVPV-DLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWK 178
            |   ....:..|.:.|:.|      :.|. |||:.........|...||..:|:|..|.||.|||
Mouse   113 T---GPDLIPEVPRQLVSNCAQRLEQGPCKDLFQELTRLTHEYLSTAPFADYLDSIYFNRFLQWK 174

  Fly   179 NLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNML 243
            .||.. .:|.|.|..:|::|:||||||..|:...||||||.|.|:|||||.::||.:||||:.:|
Mouse   175 WLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238

  Fly   244 QAVSTGIDCPFIVCMTYAFHTPDKLCFILDLMNGGDLH---YHLSQHGIFSEDEMKFYAAEVILG 305
            :.|::    .|:|.:.||:.|.|.||.:|.|||||||.   ||:.|.| |.|....|||||:..|
Mouse   239 EKVNS----RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG-FPEARAVFYAAEICCG 298

  Fly   306 LEHMHKRCIVYRDLKPANILLDENGHIRISDLGLACDFSKKKP-HASVGTHGYMAPEVLSKGTSY 369
            ||.:|:..||||||||.|||||::|||||||||||....:.:. ...|||.|||||||: :...|
Mouse   299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVV-RNERY 362

  Fly   370 DSCADWFSFGCMLYKLLKGHSPFRQHKTKDKL-EIDKMTLTMNVELPESFSLELKNLLEMLLQRD 433
            ....||::.||:||:::.|.|||:|.|.|.|. |::::...:..|..:.||.:.::|...||.:|
Mouse   363 TFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVAEEYTDRFSSQARSLCSQLLSKD 427

  Fly   434 VSKRLGCMGNGADEVKMHNFFCGIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIK 498
            .::||||.|.||.|||.|..|..:::.::......||..|....:...|..||..|  ...||:.
Mouse   428 PAERLGCRGGGAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQF--STVKGVD 490

  Fly   499 LNDADQDLYKMFSL-TISERWQQEVSET-VFDTVN 531
            |...|||.|:.|:. ::|..||.|:.|| .|..:|
Mouse   491 LEPTDQDFYQKFATGSVSIPWQNEMVETECFQELN 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	49/168 (29%)
		PKc_like	185..531	CDD:304357	155/352 (44%)
		Pkinase	191..454	CDD:278497	130/267 (49%)
		PH_GRK2_subgroup	552..675	CDD:269946
		PH	559..657	CDD:278594
Grk6	NP_001033107.1	RGS	35..179	CDD:295367	46/158 (29%)
		STKc_GRK6	185..469	CDD:270779	134/289 (46%)
		S_TKc	186..448	CDD:214567	130/267 (49%)
		N-terminal	1..185		59/205 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920