Protein Alignment Gprk1 and Grk3

DIOPT Version :10

• Sequence 1: NP_001036438.1
• Gene: Gprk1 / 3355013
• FlyBaseID: FBgn0260798
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_037029.2
• Gene: Grk3 / 25372
• RGDID: 2063
• Length: 688
• Species: Rattus norvegicus
• Alignment Length: 680
• Identity: 446/680 - (65%)
• Similarity: 531/680 - (78%)
• Gaps: 13/680 - (1%)

  Fly     1 MADLEAVLADVSYLMAMEKSKCTPAARASKKLNLPDPSVRSVMYKYLEKEGELNFHKIFNEVLGY 65
            |||||||||||||||||||||..||||||||:.||:||:||||.:||.:..|:.|.||||:.:|:
  Rat     1 MADLEAVLADVSYLMAMEKSKAAPAARASKKVVLPEPSIRSVMQRYLAERNEITFDKIFNQKIGF 65

  Fly    66 LLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDERKKMARDIYDNFIMEEMLSHTYEYSKHAVA 130
            |||||||.|:..|.:.|:||:|:||.:||.:..::|...:|.:||.:||.|:||.|:::||.||.
  Rat    66 LLFKDFCLNEIGEAVPQVKFYEEIKEYEKLDNEEDRLHRSRQMYDAYIMRELLSSTHQFSKQAVE 130

  Fly   131 SVQKYLLKNEVPVDLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKNLELNIQLTMNDFSVHR 195
            .||.:|.|.:|...||:||:|||...|:|..|:||:||:||||||||||:||||.|:||||||||
  Rat   131 HVQSHLSKKQVTPTLFQPYIEEICESLRGDIFQKFMESEKFTRFCQWKNVELNIHLSMNDFSVHR 195

  Fly   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTY 260
            |||||||||||||||||||||||||||||||:||||||.||||||.||..|||| ||||||||||
  Rat   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRVKMKQGETLALNERIMLSLVSTG-DCPFIVCMTY 259

  Fly   261 AFHTPDKLCFILDLMNGGDLHYHLSQHGIFSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANIL 325
            |||||||||||||||||||:||||||||:|||.||:|||:|:||||||||...:|||||||||||
  Rat   260 AFHTPDKLCFILDLMNGGDMHYHLSQHGVFSEKEMRFYASEIILGLEHMHTCFVVYRDLKPANIL 324

  Fly   326 LDENGHIRISDLGLACDFSKKKPHASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYKLLKGHS 390
            |||.||:|||||||||||||||||||||||||||||||.|||.|||.|||||.||||:|||:|||
  Rat   325 LDEYGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTCYDSSADWFSLGCMLFKLLRGHS 389

  Fly   391 PFRQHKTKDKLEIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSKRLGCMGNGADEVKMHNFFC 455
            ||||||||||.|||:||||:||:||::||.||::|||.|||||||:||||.|.||.|:|.|.||.
  Rat   390 PFRQHKTKDKHEIDRMTLTVNVQLPDAFSPELRSLLEGLLQRDVSQRLGCCGGGARELKEHIFFK 454

  Fly   456 GIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQDLYKMFSLTISERWQQ 520
            ||||..||::||.|||:|||||||||||||||||||||||||||.|.||||||.|.|.|||||||
  Rat   455 GIDWQYVYLRKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQDLYKNFPLVISERWQQ 519

  Fly   521 EVSETVFDTVNTETDKLEQKRKLKQKQHFDADE--KESDCILHGYIKKLGGSFASLWQTKYAKLY 583
            ||.||::|.||.||||:|.::|.|.||....::  ...|||:|||:.|||..|.:.||.:|..|:
  Rat   520 EVVETIYDAVNAETDKIEARKKAKNKQLCQEEDYAMGKDCIMHGYMLKLGNPFLTQWQRRYFYLF 584

  Fly   584 PNRLELHSESGNNKPELIFMDQVEDISSDFILHKNENCIQIRINDGTRDGRIILTNSDEIGLKEW 648
            |||||...| |.::..|:.|:|:..:....|  |:..||.:|:..|.   :.:|....:....:|
  Rat   585 PNRLEWRGE-GESRQNLLTMEQIMSVEETQI--KDRKCILLRVKGGK---QFVLQCESDPEFAQW 643

  Fly   649 SSSLRSAHKISQDLLGSMAKKAGKIYGSER 678
            ...|......:|.||    ::|.|.....|
  Rat   644 LKELTCTFNEAQRLL----RRAPKFLNKPR 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	83/155 (54%)
		Protein Kinases, catalytic domain	185..531	CDD:473864	286/345 (83%)
		PH_GRK2_subgroup	552..675	CDD:269946	38/124 (31%)
Grk3	NP_037029.2	N-terminal	1..190		112/188 (60%)
		RGS_GRK2_GRK3	30..186	CDD:188701	83/155 (54%)
		Protein Kinases, catalytic domain	185..530	CDD:473864	286/345 (83%)
		PH_GRK2_subgroup	553..670	CDD:269946	39/127 (31%)