DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gprk1 and Grk3

DIOPT Version :9

Sequence 1:	NP_001036438.1	Gene:	Gprk1 / 3355013	FlyBaseID:	FBgn0260798	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_037029.2	Gene:	Grk3 / 25372	RGDID:	2063	Length:	688	Species:	Rattus norvegicus

Alignment Length:	680	Identity:	446/680 - (65%)
Similarity:	531/680 - (78%)	Gaps:	13/680 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADLEAVLADVSYLMAMEKSKCTPAARASKKLNLPDPSVRSVMYKYLEKEGELNFHKIFNEVLGY 65
            |||||||||||||||||||||..||||||||:.||:||:||||.:||.:..|:.|.||||:.:|:
  Rat     1 MADLEAVLADVSYLMAMEKSKAAPAARASKKVVLPEPSIRSVMQRYLAERNEITFDKIFNQKIGF 65

  Fly    66 LLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDERKKMARDIYDNFIMEEMLSHTYEYSKHAVA 130
            |||||||.|:..|.:.|:||:|:||.:||.:..::|...:|.:||.:||.|:||.|:::||.||.
  Rat    66 LLFKDFCLNEIGEAVPQVKFYEEIKEYEKLDNEEDRLHRSRQMYDAYIMRELLSSTHQFSKQAVE 130

  Fly   131 SVQKYLLKNEVPVDLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKNLELNIQLTMNDFSVHR 195
            .||.:|.|.:|...||:||:|||...|:|..|:||:||:||||||||||:||||.|:||||||||
  Rat   131 HVQSHLSKKQVTPTLFQPYIEEICESLRGDIFQKFMESEKFTRFCQWKNVELNIHLSMNDFSVHR 195

  Fly   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTY 260
            |||||||||||||||||||||||||||||||:||||||.||||||.||..|||| ||||||||||
  Rat   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRVKMKQGETLALNERIMLSLVSTG-DCPFIVCMTY 259

  Fly   261 AFHTPDKLCFILDLMNGGDLHYHLSQHGIFSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANIL 325
            |||||||||||||||||||:||||||||:|||.||:|||:|:||||||||...:|||||||||||
  Rat   260 AFHTPDKLCFILDLMNGGDMHYHLSQHGVFSEKEMRFYASEIILGLEHMHTCFVVYRDLKPANIL 324

  Fly   326 LDENGHIRISDLGLACDFSKKKPHASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYKLLKGHS 390
            |||.||:|||||||||||||||||||||||||||||||.|||.|||.|||||.||||:|||:|||
  Rat   325 LDEYGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTCYDSSADWFSLGCMLFKLLRGHS 389

  Fly   391 PFRQHKTKDKLEIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSKRLGCMGNGADEVKMHNFFC 455
            ||||||||||.|||:||||:||:||::||.||::|||.|||||||:||||.|.||.|:|.|.||.
  Rat   390 PFRQHKTKDKHEIDRMTLTVNVQLPDAFSPELRSLLEGLLQRDVSQRLGCCGGGARELKEHIFFK 454

  Fly   456 GIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQDLYKMFSLTISERWQQ 520
            ||||..||::||.|||:|||||||||||||||||||||||||||.|.||||||.|.|.|||||||
  Rat   455 GIDWQYVYLRKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQDLYKNFPLVISERWQQ 519

  Fly   521 EVSETVFDTVNTETDKLEQKRKLKQKQHFDADE--KESDCILHGYIKKLGGSFASLWQTKYAKLY 583
            ||.||::|.||.||||:|.::|.|.||....::  ...|||:|||:.|||..|.:.||.:|..|:
  Rat   520 EVVETIYDAVNAETDKIEARKKAKNKQLCQEEDYAMGKDCIMHGYMLKLGNPFLTQWQRRYFYLF 584

  Fly   584 PNRLELHSESGNNKPELIFMDQVEDISSDFILHKNENCIQIRINDGTRDGRIILTNSDEIGLKEW 648
            |||||...| |.::..|:.|:|:..:....|  |:..||.:|:..|.   :.:|....:....:|
  Rat   585 PNRLEWRGE-GESRQNLLTMEQIMSVEETQI--KDRKCILLRVKGGK---QFVLQCESDPEFAQW 643

  Fly   649 SSSLRSAHKISQDLLGSMAKKAGKIYGSER 678
            ...|......:|.||    ::|.|.....|
  Rat   644 LKELTCTFNEAQRLL----RRAPKFLNKPR 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	83/155 (54%)
		PKc_like	185..531	CDD:304357	286/345 (83%)
		Pkinase	191..454	CDD:278497	221/262 (84%)
		PH_GRK2_subgroup	552..675	CDD:269946	38/124 (31%)
		PH	559..657	CDD:278594	31/97 (32%)
Grk3	NP_037029.2	N-terminal	1..190		112/188 (60%)
		RGS_GRK2_GRK3	30..186	CDD:188701	83/155 (54%)
		PKc_like	185..530	CDD:419665	286/345 (83%)
		PH_GRK2_subgroup	553..670	CDD:269946	39/127 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	465	1.000	Domainoid score	I448
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21072
Inparanoid	1	1.050	908	1.000	Inparanoid score	I350
OMA	1	1.010	-	-		QHG45729
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	1	1.000	-	-		FOG0004399
OrthoInspector	1	1.000	-	-		otm44817
orthoMCL	1	0.900	-	-		OOG6_106250
Panther	1	1.100	-	-	LDO	PTHR24355
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3114
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980