DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gprk1 and Grk2

DIOPT Version :9

Sequence 1:	NP_001036438.1	Gene:	Gprk1 / 3355013	FlyBaseID:	FBgn0260798	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_036908.2	Gene:	Grk2 / 25238	RGDID:	2062	Length:	689	Species:	Rattus norvegicus

Alignment Length:	674	Identity:	451/674 - (66%)
Similarity:	539/674 - (79%)	Gaps:	9/674 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADLEAVLADVSYLMAMEKSKCTPAARASKKLNLPDPSVRSVMYKYLEKEGELNFHKIFNEVLGY 65
            |||||||||||||||||||||.|||||||||:.||:||:||||.||||..||:.|.|||::.|||
  Rat     1 MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGY 65

  Fly    66 LLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDERKKMARDIYDNFIMEEMLSHTYEYSKHAVA 130
            |||:|||.|..||....::|:|:||.:||.|..:||...:|:|:|::||:|:|:.::.:||:|..
  Rat    66 LLFRDFCLNHLEEAKPLVEFYEEIKKYEKLETEEERVVRSREIFDSYIMKELLACSHPFSKNATE 130

  Fly   131 SVQKYLLKNEVPVDLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKNLELNIQLTMNDFSVHR 195
            .||.:|:|.:||.|||:||:|||...|:|..|.||:|||||||||||||:||||.||||||||||
  Rat   131 HVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFHKFIESDKFTRFCQWKNVELNIHLTMNDFSVHR 195

  Fly   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTY 260
            ||||||||||||||||||||||||||||||||||||||.||||||.||..|||| ||||||||:|
  Rat   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG-DCPFIVCMSY 259

  Fly   261 AFHTPDKLCFILDLMNGGDLHYHLSQHGIFSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANIL 325
            ||||||||.|||||||||||||||||||:|||.:|:|||||:||||||||.|.:|||||||||||
  Rat   260 AFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANIL 324

  Fly   326 LDENGHIRISDLGLACDFSKKKPHASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYKLLKGHS 390
            |||:||:|||||||||||||||||||||||||||||||.||.:|||.|||||.||||:|||:|||
  Rat   325 LDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHS 389

  Fly   391 PFRQHKTKDKLEIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSKRLGCMGNGADEVKMHNFFC 455
            ||||||||||.|||:|||||.||||:|||.||::|||.||||||::||||:|.||.|||...||.
  Rat   390 PFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454

  Fly   456 GIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQDLYKMFSLTISERWQQ 520
            .:||..|::|||.|||:|||||||||||||||||||||||||||.|:||:||:.|.|||||||||
  Rat   455 SLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQ 519

  Fly   521 EVSETVFDTVNTETDKLEQKRKLKQKQ--HFDADEKESDCILHGYIKKLGGSFASLWQTKYAKLY 583
            ||:||||||:|.|||:||.::|.|.||  |.:......|||:|||:.|:|..|.:.||.:|..|:
  Rat   520 EVAETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLF 584

  Fly   584 PNRLELHSESGNNKPELIFMDQVEDISSDFILHKNENCIQIRINDGTRDGRIILTNSDEIGLKEW 648
            |||||...| |.....|:.|::::.:....|  |...|:.::|..|.   :.:|....:..|.:|
  Rat   585 PNRLEWRGE-GEAPQSLLTMEEIQSVEETQI--KERKCLLLKIRGGK---QFVLQCDSDPELVQW 643

  Fly   649 SSSLRSAHKISQDLLGSMAKKAGK 672
            ...||.|::.:|.|:..:.|...|
  Rat   644 KKELRDAYREAQQLVQRVPKMKNK 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	87/155 (56%)
		PKc_like	185..531	CDD:304357	288/345 (83%)
		Pkinase	191..454	CDD:278497	222/262 (85%)
		PH_GRK2_subgroup	552..675	CDD:269946	37/121 (31%)
		PH	559..657	CDD:278594	31/97 (32%)
Grk2	NP_036908.2	N-terminal	1..190		118/188 (63%)
		RGS_GRK2_GRK3	30..186	CDD:188701	87/155 (56%)
		STKc_GRK2	190..510	CDD:271125	266/320 (83%)
		PH_GRK2_subgroup	553..670	CDD:269946	37/121 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348840
Domainoid	1	1.000	465	1.000	Domainoid score	I448
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	908	1.000	Inparanoid score	I350
OMA	1	1.010	-	-		QHG45729
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	1	1.000	-	-		FOG0004399
OrthoInspector	1	1.000	-	-		otm44817
orthoMCL	1	0.900	-	-		OOG6_106250
Panther	1	1.100	-	-	O	PTHR24355
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3114
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770