Protein Alignment Gprk1 and Grk1

DIOPT Version :9

• Sequence 1: NP_001036438.1
• Gene: Gprk1 / 3355013
• FlyBaseID: FBgn0260798
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_036011.3
• Gene: Grk1 / 24013
• MGIID: 1345146
• Length: 564
• Species: Mus musculus
• Alignment Length: 561
• Identity: 197/561 - (35%)
• Similarity: 295/561 - (52%)
• Gaps: 67/561 - (11%)

  Fly     4 LEAVLADVSYLMAMEK--SKCTPAARASK---KLNLPDPSVRSVMYKYLEKEG-----ELNFHKI 58
            ||.|:|:.:::.|...  ...||::|..|   ||.||..|         :.||     .|.|..:
Mouse     6 LETVVANSAFIAARGSFDGSSTPSSRDKKYLAKLRLPPLS---------KCEGLRDNLSLEFESL 61

  Fly    59 FNE-VLGYLLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDERKKMARDI-----------YDN 111
            .:| .:|..||:.|.:.| |..:..|:.::.|:.:: |...|.|.:.|:.|           :.|
Mouse    62 CSEQPIGKRLFQQFLKTD-ERHVPALELWKDIEDYD-TADDDLRPQKAQAILAEYLDPQGTLFCN 124

  Fly   112 FIMEEMLSHTYEYSKHAVASVQKYLLKNEVPVDLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQ 176
            |:.:.|::..    |......|.         .||:|.|:.....|...||:::|||..|.||.|
Mouse   125 FLDQGMVTRV----KEGPTGSQD---------GLFQPLLQATMEHLSQAPFQEYLESLYFLRFLQ 176

  Fly   177 WKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERN 241
            ||.||.. .:..:.|...|::|:||||||..|:...||||||.|.|:|||:|.::|...|:.|:.
Mouse   177 WKWLEAQ-PIGEDWFLDFRVLGKGGFGEVSACQMKATGKMYACKKLNKKRLKKRKGYQGAIVEKR 240

  Fly   242 MLQAVSTGIDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHL----SQHGIFSEDEMKFYAAEV 302
            :|    |.:...|||.:.|||.|...||.::.:|||||:.||:    ..:..|||....:|.|::
Mouse   241 IL----TKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDVRYHIYNVDEDNPGFSEPRAIYYTAQI 301

  Fly   303 ILGLEHMHKRCIVYRDLKPANILLDENGHIRISDLGLACDF----SKKKPHASVGTHGYMAPEVL 363
            |.||||:|:|.||||||||.|:|||.:|:|||||||||.:.    :|.|.:|  ||.|:||||:|
Mouse   302 ISGLEHLHQRRIVYRDLKPENVLLDNDGNIRISDLGLAVELKEGQNKTKGYA--GTPGFMAPELL 364

  Fly   364 SKGTSYDSCADWFSFGCMLYKLLKGHSPFRQHKTK-DKLEIDKMTLTMNVELPESFSLELKNLLE 427
             :|..||...|:|:.|..||:::....|||....| :..|:.:..::..|:.||.||...|:..|
Mouse   365 -RGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRIISEPVKYPEKFSQASKDFCE 428

  Fly   428 MLLQRDVSKRLGCMGNGADEVKMHNFFCGIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEE 492
            .||::|..||||......|.::.:..|..|.|.|:......||.:|....|.|.:..|:|:|  .
Mouse   429 QLLEKDPEKRLGFRDGTCDALRANVLFKDISWRQLEAGMLIPPFIPDSRTVYAKNIQDVGAF--S 491

  Fly   493 DTKGIKLNDADQDLYKMF-SLTISERWQQEVSET-VFDTVN 531
            ..||:..:.||.:.::.| |...|..||:|:.|| :|..:|
Mouse   492 TVKGVVFDKADTEFFQEFASGNCSIPWQEEMIETGLFGDLN 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	47/175 (27%)
		PKc_like	185..531	CDD:304357	141/356 (40%)
		Pkinase	191..454	CDD:278497	116/271 (43%)
		PH_GRK2_subgroup	552..675	CDD:269946
		PH	559..657	CDD:278594
Grk1	NP_036011.3	N-terminal	1..189		55/207 (27%)
		Interaction with RCVRN. /evidence=ECO:0000250|UniProtKB:P28327	1..15		4/8 (50%)
		RGS	42..179	CDD:383028	40/160 (25%)
		STKc_GRK1	188..475	CDD:270759	122/293 (42%)
		C-terminal	456..564		25/79 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820