DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gprk1 and Grk1

DIOPT Version :10

Sequence 1:NP_001036438.1 Gene:Gprk1 / 3355013 FlyBaseID:FBgn0260798 Length:700 Species:Drosophila melanogaster
Sequence 2:NP_036011.3 Gene:Grk1 / 24013 MGIID:1345146 Length:564 Species:Mus musculus


Alignment Length:561 Identity:197/561 - (35%)
Similarity:295/561 - (52%) Gaps:67/561 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 LEAVLADVSYLMAMEK--SKCTPAARASK---KLNLPDPSVRSVMYKYLEKEG-----ELNFHKI 58
            ||.|:|:.:::.|...  ...||::|..|   ||.||..|         :.||     .|.|..:
Mouse     6 LETVVANSAFIAARGSFDGSSTPSSRDKKYLAKLRLPPLS---------KCEGLRDNLSLEFESL 61

  Fly    59 FNE-VLGYLLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDERKKMARDI-----------YDN 111
            .:| .:|..||:.|.:.| |..:..|:.::.|:.:: |...|.|.:.|:.|           :.|
Mouse    62 CSEQPIGKRLFQQFLKTD-ERHVPALELWKDIEDYD-TADDDLRPQKAQAILAEYLDPQGTLFCN 124

  Fly   112 FIMEEMLSHTYEYSKHAVASVQKYLLKNEVPVDLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQ 176
            |:.:.|::..    |......|.         .||:|.|:.....|...||:::|||..|.||.|
Mouse   125 FLDQGMVTRV----KEGPTGSQD---------GLFQPLLQATMEHLSQAPFQEYLESLYFLRFLQ 176

  Fly   177 WKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERN 241
            ||.||.. .:..:.|...|::|:||||||..|:...||||||.|.|:|||:|.::|...|:.|:.
Mouse   177 WKWLEAQ-PIGEDWFLDFRVLGKGGFGEVSACQMKATGKMYACKKLNKKRLKKRKGYQGAIVEKR 240

  Fly   242 MLQAVSTGIDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHL----SQHGIFSEDEMKFYAAEV 302
            :|    |.:...|||.:.|||.|...||.::.:|||||:.||:    ..:..|||....:|.|::
Mouse   241 IL----TKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDVRYHIYNVDEDNPGFSEPRAIYYTAQI 301

  Fly   303 ILGLEHMHKRCIVYRDLKPANILLDENGHIRISDLGLACDF----SKKKPHASVGTHGYMAPEVL 363
            |.||||:|:|.||||||||.|:|||.:|:|||||||||.:.    :|.|.:|  ||.|:||||:|
Mouse   302 ISGLEHLHQRRIVYRDLKPENVLLDNDGNIRISDLGLAVELKEGQNKTKGYA--GTPGFMAPELL 364

  Fly   364 SKGTSYDSCADWFSFGCMLYKLLKGHSPFRQHKTK-DKLEIDKMTLTMNVELPESFSLELKNLLE 427
             :|..||...|:|:.|..||:::....|||....| :..|:.:..::..|:.||.||...|:..|
Mouse   365 -RGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRIISEPVKYPEKFSQASKDFCE 428

  Fly   428 MLLQRDVSKRLGCMGNGADEVKMHNFFCGIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEE 492
            .||::|..||||......|.::.:..|..|.|.|:......||.:|....|.|.:..|:|:|  .
Mouse   429 QLLEKDPEKRLGFRDGTCDALRANVLFKDISWRQLEAGMLIPPFIPDSRTVYAKNIQDVGAF--S 491

  Fly   493 DTKGIKLNDADQDLYKMF-SLTISERWQQEVSET-VFDTVN 531
            ..||:..:.||.:.::.| |...|..||:|:.|| :|..:|
Mouse   492 TVKGVVFDKADTEFFQEFASGNCSIPWQEEMIETGLFGDLN 532

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gprk1NP_001036438.1 RGS_GRK2_GRK3 30..186 CDD:188701 47/175 (27%)
Protein Kinases, catalytic domain 185..531 CDD:473864 141/356 (40%)
PH_GRK2_subgroup 552..675 CDD:269946
Grk1NP_036011.3 N-terminal 1..189 55/207 (27%)
Interaction with RCVRN. /evidence=ECO:0000250|UniProtKB:P28327 1..15 4/8 (50%)
RGS 42..179 CDD:470619 40/160 (25%)
STKc_GRK1 188..475 CDD:270759 122/293 (42%)
C-terminal 456..564 25/79 (32%)
Blue background indicates that the domain is not in the aligned region.

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